Search: (WFRF:(Kidwell Chelsea S.))
> (2012) >
Burden of Risk Alle...
Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage
-
Falcone, Guido J. (author)
-
Biffi, Alessandro (author)
-
Devan, William J. (author)
-
show more...
-
Jagiella, Jeremiasz M. (author)
-
Schmidt, Helena (author)
-
Kissela, Brett (author)
-
- Hansen, Björn (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Jimenez-Conde, Jordi (author)
-
Giralt-Steinhauer, Eva (author)
-
Elosua, Roberto (author)
-
Cuadrado-Godia, Elisa (author)
-
Soriano, Carolina (author)
-
Ayres, Alison M. (author)
-
Schwab, Kristin (author)
-
Pera, Joanna (author)
-
Urbanik, Andrzej (author)
-
Rost, Natalia S. (author)
-
Goldstein, Joshua N. (author)
-
Viswanathan, Anand (author)
-
Pichler, Alexander (author)
-
Enzinger, Christian (author)
-
- Norrving, Bo (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Tirschwell, David L. (author)
-
Selim, Magdy (author)
-
Brown, Devin L. (author)
-
Silliman, Scott L. (author)
-
Worrall, Bradford B. (author)
-
Meschia, James F. (author)
-
Kidwell, Chelsea S. (author)
-
Montaner, Joan (author)
-
Fernandez-Cadenas, Israel (author)
-
Delgado, Pilar (author)
-
Broderick, Joseph P. (author)
-
Greenberg, Steven M. (author)
-
Roquer, Jaume (author)
-
- Lindgren, Arne (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Slowik, Agnieszka (author)
-
Schmidt, Reinhold (author)
-
Flaherty, Matthew L. (author)
-
Kleindorfer, Dawn O. (author)
-
Langefeld, Carl D. (author)
-
Woo, Daniel (author)
-
Rosand, Jonathan (author)
-
show less...
-
(creator_code:org_t)
- 2012
- 2012
- English.
-
In: Stroke: a journal of cerebral circulation. - 1524-4628. ; 43:11, s. 2877-2883
- Related links:
-
https://portal.resea... (primary) (free)
-
show more...
-
http://dx.doi.org/10...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background and Purpose-Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN. Methods-We conducted a prospective multicenter case-control study in 2272 subjects of European ancestry (1025 cases and 1247 control subjects). Thirty-nine SNPs reported to be associated with blood pressure levels were identified from the National Human Genome Research Institute genomewide association study catalog. Single-SNP association analyses were performed for the outcomes ICH and pre-ICH HTN. Subsequently, weighted and unweighted genetic risk scores were constructed using these SNPs and entered as the independent variable in logistic regression models with ICH and pre-ICH HTN as the dependent variables. Results-No single SNP was associated with either ICH or pre-ICH HTN. The blood pressure-based unweighted genetic risk score was associated with risk of ICH (OR, 1.11; 95% CI, 1.02-1.21; P=0.01) and the subset of ICH in deep regions (OR, 1.18; 95% CI, 1.07-1.30; P=0.001), but not with the subset of lobar ICH. The score was associated with a history of HTN among control subjects (OR, 1.17; 95% CI, 1.04-1.31; P=0.009) and ICH cases (OR, 1.15; 95% CI, 1.01-1.31; P=0.04). Similar results were obtained when using a weighted score. Conclusion-Increasing numbers of high blood pressure-related alleles are associated with increased risk of deep ICH as well as with clinically identified HTN. (Stroke. 2012; 43: 2877-2883.)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- genetic risk score
- genetics
- hypertension
- intracerebral hemorrhage
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Falcone, Guido J ...
-
Biffi, Alessandr ...
-
Devan, William J ...
-
Jagiella, Jeremi ...
-
Schmidt, Helena
-
Kissela, Brett
-
show more...
-
Hansen, Björn
-
Jimenez-Conde, J ...
-
Giralt-Steinhaue ...
-
Elosua, Roberto
-
Cuadrado-Godia, ...
-
Soriano, Carolin ...
-
Ayres, Alison M.
-
Schwab, Kristin
-
Pera, Joanna
-
Urbanik, Andrzej
-
Rost, Natalia S.
-
Goldstein, Joshu ...
-
Viswanathan, Ana ...
-
Pichler, Alexand ...
-
Enzinger, Christ ...
-
Norrving, Bo
-
Tirschwell, Davi ...
-
Selim, Magdy
-
Brown, Devin L.
-
Silliman, Scott ...
-
Worrall, Bradfor ...
-
Meschia, James F ...
-
Kidwell, Chelsea ...
-
Montaner, Joan
-
Fernandez-Cadena ...
-
Delgado, Pilar
-
Broderick, Josep ...
-
Greenberg, Steve ...
-
Roquer, Jaume
-
Lindgren, Arne
-
Slowik, Agnieszk ...
-
Schmidt, Reinhol ...
-
Flaherty, Matthe ...
-
Kleindorfer, Daw ...
-
Langefeld, Carl ...
-
Woo, Daniel
-
Rosand, Jonathan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Stroke: a journa ...
- By the university
-
Lund University