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- Landin-Wilhelmsen, Kerstin, 1952, et al.
(författare)
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Calcaneal ultrasound measurements are determined by age and physical activity. Studies in two Swedish random population samples.
- 2000
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Ingår i: Journal of internal medicine. - 0954-6820. ; 247:2, s. 269-78
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To present reference values and correlations with body composition, blood variables and lifestyle factors. SUBJECTS: Two random population samples from Göteborg, Sweden, one comprising 184 men and 455 women aged 25-64 years (MONICA) and the other 860 women aged 55-82 years (BEDA) were studied. METHODS: Calcaneal ultrasound measurement (LUNAR Achilles) and bioimpedance were measured. Smoking habits, coffee consumption, physical activity, psychological stress, education and marital status, as well as blood lipids, blood pressure, and fractures were studied. RESULTS: Broadband ultrasound attenuation and stiffness were higher in men than in women (P < 0. 001), but speed of sound did not differ between sexes. Speed of sound, broadband ultrasound attenuation and stiffness decreased with age (P < 0.001). In both sexes speed of sound, broadband ultrasound attenuation and stiffness correlated positively to body size variables, and negatively with smoking in women after adjustment for age. Speed of sound, broadband ultrasound attenuation and stiffness were positively related to physical activity in both sexes, and these relationships were the only ones that remained in multivariate analyses in addition to age (negative). Osteoporotic fractures increased with age. Speed of sound, broadband ultrasound attenuation and stiffness were lower amongst women with osteoporotic fractures. CONCLUSION: Speed of sound, broadband ultrasound attenuation and stiffness decreased with age and increased with physical activity, but body weight and height were not correlated in multivariate analyses. Osteoporotic fractures increased with age and were associated with lower calcaneal ultrasound values.
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| 2. |
- Landin-Wilhelmsen, Kerstin, 1952, et al.
(författare)
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Insulin-like growth factor I levels in healthy adults.
- 2004
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Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 62 Suppl 1, s. 8-16
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Tidskriftsartikel (refereegranskat)abstract
- Insulin-like growth factor I (IGF-I) levels mainly reflect secretion of growth hormone (GH) in the body. The aims of this study were to compare different IGF-I assay methods in healthy individuals, test the reliability of the methods and discuss the utility of IGF-I measurement in adults. The Nichols Institute Diagnostics radioimmunoassay was used to evaluate IGF-I in two random population samples of men and women (aged 25-64 years, n = 392) taken 10 years apart, in 1985 and 1995. This method for IGF-I testing was also compared with an immunoradiometric assay (IRMA) method in 387 men and women participating in the World Health Organization MONICA (MONItoring of trends and determinants for CArdiovascular diseases) Project, Goteborg, Sweden, in 1995. Serum IGF-I decreased with increasing age in both men and women. IGF-I was higher in young women compared with young men in both cohorts, while the opposite was found in the highest age group. Age-adjusted significant correlations were found between IGF-I and smoking, fibrinogen, coffee consumption, lipoprotein (a), osteocalcin and IGF-binding protein 3. The two cohorts showed similar mean IGF-I concentrations irrespective of method. The correlation between the Nichols and the IRMA methods was high: r = 0.93 (p < 0.0001). Based on this and previous studies, population-based IGF-I measurements are robust irrespective of which commercially available method of assay is used. IGF-I levels can be used in diagnosing acromegaly as well as providing target values. IGF-I assay can be used as a complement to stimulation testing in the diagnosis of GH deficiency, and as a tool for GH dose titration.
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| 4. |
- Welin, Catharina, 1945, et al.
(författare)
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Independent importance of psychosocial factors for prognosis after myocardial infarction.
- 2000
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Ingår i: Journal of Internal Medicine. - 0954-6820. ; 247:6, s. 629-639
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: As a primary aim it was tested whether the 10-year prognosis after a myocardial infarction is related to psychological stress, lack of social support, anxiety, and/or depressive tendency. A secondary aim was to analyse the prognostic importance of a series of other psychosocial factors as well as interactions. METHODS: Non-selected patients aged below 65 years with a first infarction (230 men and 45 women) were followed for 10 years with 100% assessment of morbidity and cause-specific mortality. Baseline somatic and psychosocial variables were collected with the aid of standard, validated questionnaires. RESULTS: In multivariate analysis, factors increasing risk for coronary mortality included female sex (hazard ratio, +/- 95% confidence interval) 2.47 (1.06, 5.71), signs of left ventricular failure 3.93 (1.87, 8.26), ventricular dysrhythmia 3 months after the infarction 5.45 (2.21, 13. 42), high depression scores 3.16 (1.38, 7.25) and lack of social support 2.75 (1.29, 5.89). All-cause mortality was significantly related to left ventricular failure, ventricular dysrhythmias, and high depression scores with borderline significance for female sex and social support. Prognosis was affected during the entire follow-up period. It was not significantly associated with age, marital status, education, extra work, mental strain at work or in the marriage, anxiety, dissatisfaction with family life, problems with children, dissatisfaction with the financial situation, life events, anger-in, irritability, type A behaviour, or health locus of control. Incidence of nonfatal infarction was not associated with any of the baseline variables. CONCLUSION: In addition to known somatic predictors of prognosis after a myocardial infarction, prognosis is strongly influenced by depression and lack of social support, but not to a series of other psychosocial factors. It is recommended to use self-reporting scales to detect prognostically important psychosocial problems. PMID: 10886484 [PubMed - indexed for MEDLINE]
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| 5. |
- Wilhelmsen, Lars, 1932, et al.
(författare)
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Risk of coronary events by baseline factors during 28 years follow-up and three periods in a random population sample of men
- 2004
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Ingår i: J Intern Med. - 0954-6820. ; 256:4, s. 298-307
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To investigate the predictive value of risk factors for coronary events measured in midlife during three separate periods over a follow-up period extending through 28 years. METHODS: A total of 7437 men aged 47-55 years and free of myocardial infarction at baseline were examined. Risk of coronary events (nonfatal myocardial infarction and coronary deaths) was analysed for the entire period and for 0-15, 16-21 and 22-28 years' follow-up, using age-adjusted and multiple Cox regression analyses. RESULTS: Age, diabetes, elevated blood pressure and serum cholesterol were all independently associated with increased risk of coronary events for the entire 28 years as well as for each of the periods. A family history of coronary events amongst fathers, mothers and siblings was independently significant for the entire follow-up period, and the risk did not decline with extended follow-up. Effort-related chest pain was a strong and independent risk factor for the first 21 years but not thereafter. The importance of smoking decreased over time and was not significantly associated with outcome during the last period. Stress was also significant for the entire 28 years, but in selected periods only up to 21 years. Body mass index, low physical activity and low social class were inconsistently or not at all related to outcome in multiple analyses.
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