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Combined associatio...
Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
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Kapoor, Pooja Middha (author)
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Mavaddat, Nasim (author)
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Choudhury, Parichoy Pal (author)
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show more...
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Wilcox, Amber N. (author)
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Lindström, Sara (author)
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Behrens, Sabine (author)
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Michailidou, Kyriaki (author)
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Dennis, Joe (author)
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Bolla, Manjeet K. (author)
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Wang, Qin (author)
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Jung, Audrey (author)
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Abu-Ful, Zomoroda (author)
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Ahearn, Thomas (author)
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Andrulis, Irene L. (author)
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Anton-Culver, Hoda (author)
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Arndt, Volker (author)
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Aronson, Kristan J. (author)
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Auer, Paul L. (author)
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Beane Freeman, Laura E. (author)
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Becher, Heiko (author)
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Beckmann, Matthias W. (author)
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Beeghly-Fadiel, Alicia (author)
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Benitez, Javier (author)
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Bernstein, Leslie (author)
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Bojesen, Stig E. (author)
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Brauch, Hiltrud (author)
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Brenner, Hermann (author)
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Brüning, Thomas (author)
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Cai, Qiuyin (author)
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Campa, Daniele (author)
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Canzian, Federico (author)
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Carracedo, Angel (author)
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Carter, Brian D. (author)
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Castelao, Jose E. (author)
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Chanock, Stephen J. (author)
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Chatterjee, Nilanjan (author)
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Chenevix-Trench, Georgia (author)
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Clarke, Christine L. (author)
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Couch, Fergus J. (author)
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Cox, Angela (author)
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Cross, Simon S. (author)
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- Czene, Kamila (author)
- Karolinska Institutet
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Dai, James Y. (author)
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Earp, H. Shelton (author)
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Ekici, Arif B. (author)
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Eliassen, A. Heather (author)
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- Eriksson, Mikael (author)
- Karolinska Institutet
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Evans, D. Gareth (author)
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Fasching, Peter A. (author)
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Figueroa, Jonine (author)
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Fritschi, Lin (author)
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- Gabrielson, Marike (author)
- Karolinska Institutet
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Gago-Dominguez, Manuela (author)
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Gao, Chi (author)
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Gapstur, Susan M. (author)
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Gaudet, Mia M. (author)
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Giles, Graham G. (author)
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González-Neira, Anna (author)
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Guénel, Pascal (author)
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Haeberle, Lothar (author)
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Haiman, Christopher A. (author)
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- Håkansson, Niclas (author)
- Karolinska Institutet
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- Hall, Per (author)
- Karolinska Institutet
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Hamann, Ute (author)
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Hatse, Sigrid (author)
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Heyworth, Jane (author)
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Holleczek, Bernd (author)
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Hoover, Robert N. (author)
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Hopper, John L. (author)
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Howell, Anthony (author)
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Hunter, David J. (author)
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John, Esther M. (author)
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Jones, Michael E. (author)
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Kaaks, Rudolf (author)
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Keeman, Renske (author)
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Kitahara, Cari M. (author)
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Ko, Yon-Dschun (author)
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Koutros, Stella (author)
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- Kurian, Allison W. (author)
- Karolinska Institutet
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Lambrechts, Diether (author)
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Le Marchand, Loic (author)
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Lee, Eunjung (author)
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Lejbkowicz, Flavio (author)
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Linet, Martha (author)
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Lissowska, Jolanta (author)
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Llaneza, Ana (author)
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MacInnis, Robert J. (author)
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Martinez, Maria Elena (author)
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Maurer, Tabea (author)
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McLean, Catriona (author)
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Neuhausen, Susan L. (author)
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Newman, William G. (author)
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Norman, Aaron (author)
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O'Brien, Katie M. (author)
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Olshan, Andrew F. (author)
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Olson, Janet E. (author)
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Olsson, Håkan (author)
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Orr, Nick (author)
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Perou, Charles M. (author)
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Pita, Guillermo (author)
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Polley, Eric C. (author)
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Prentice, Ross L. (author)
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Rennert, Gad (author)
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Rennert, Hedy S. (author)
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Ruddy, Kathryn J. (author)
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Sandler, Dale P. (author)
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Saunders, Christobel (author)
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Schoemaker, Minouk J. (author)
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Schöttker, Ben (author)
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Schumacher, Fredrick (author)
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Scott, Christopher (author)
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Scott, Rodney J. (author)
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Shu, Xiao-Ou (author)
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Smeets, Ann (author)
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Southey, Melissa C. (author)
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Spinelli, John J. (author)
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Stone, Jennifer (author)
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Swerdlow, Anthony J. (author)
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Tamimi, Rulla M. (author)
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Taylor, Jack A. (author)
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Troester, Melissa A. (author)
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Vachon, Celine M. (author)
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van Veen, Elke M. (author)
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Wang, Xiaoliang (author)
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Weinberg, Clarice R. (author)
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Weltens, Caroline (author)
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Willett, Walter (author)
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Winham, Stacey J. (author)
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- Wolk, Alicja (author)
- Uppsala universitet,Medicinsk epidemiologi,Karolinska institutet
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Yang, Xiaohong R. (author)
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Zheng, Wei (author)
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Ziogas, Argyrios (author)
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Dunning, Alison M. (author)
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Pharoah, Paul D. P. (author)
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Schmidt, Marjanka K. (author)
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Kraft, Peter (author)
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Easton, Douglas F. (author)
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Milne, Roger L. (author)
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García-Closas, Montserrat (author)
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Chang-Claude, Jenny (author)
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(creator_code:org_t)
- 2020-05-02
- 2021
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 113:3, s. 329-337
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Breast cancer
- Epidemiology
- Gene-environment interactions
- Genetic susceptibility
- Polygenic risk score
- Risk factors
- Risk prediction
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kapoor, Pooja Mi ...
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Mavaddat, Nasim
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Choudhury, Paric ...
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Wilcox, Amber N.
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Lindström, Sara
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Behrens, Sabine
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show more...
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Michailidou, Kyr ...
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Dennis, Joe
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Bolla, Manjeet K ...
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Wang, Qin
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Jung, Audrey
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Abu-Ful, Zomorod ...
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Ahearn, Thomas
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Andrulis, Irene ...
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Anton-Culver, Ho ...
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Arndt, Volker
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Aronson, Kristan ...
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Auer, Paul L.
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Beane Freeman, L ...
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Becher, Heiko
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Beckmann, Matthi ...
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Beeghly-Fadiel, ...
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Benitez, Javier
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Bernstein, Lesli ...
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Bojesen, Stig E.
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Brauch, Hiltrud
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Brenner, Hermann
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Brüning, Thomas
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Cai, Qiuyin
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Campa, Daniele
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Canzian, Federic ...
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Carracedo, Angel
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Carter, Brian D.
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Castelao, Jose E ...
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Chanock, Stephen ...
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Chatterjee, Nila ...
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Chenevix-Trench, ...
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Clarke, Christin ...
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Couch, Fergus J.
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Cox, Angela
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Cross, Simon S.
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Czene, Kamila
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Dai, James Y.
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Earp, H. Shelton
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Ekici, Arif B.
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Eliassen, A. Hea ...
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Eriksson, Mikael
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Evans, D. Gareth
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Fasching, Peter ...
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Figueroa, Jonine
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Fritschi, Lin
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Gabrielson, Mari ...
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Gago-Dominguez, ...
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Gao, Chi
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Gapstur, Susan M ...
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Gaudet, Mia M.
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Giles, Graham G.
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González-Neira, ...
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Guénel, Pascal
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Haeberle, Lothar
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Haiman, Christop ...
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Håkansson, Nicla ...
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Hall, Per
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Hamann, Ute
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Hatse, Sigrid
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Heyworth, Jane
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Holleczek, Bernd
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Hoover, Robert N ...
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Hopper, John L.
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Howell, Anthony
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Hunter, David J.
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John, Esther M.
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Jones, Michael E ...
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Kaaks, Rudolf
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Keeman, Renske
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Kitahara, Cari M ...
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Ko, Yon-Dschun
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Koutros, Stella
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Kurian, Allison ...
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Lambrechts, Diet ...
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Le Marchand, Loi ...
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Lee, Eunjung
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Lejbkowicz, Flav ...
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Linet, Martha
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Lissowska, Jolan ...
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Llaneza, Ana
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MacInnis, Robert ...
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Martinez, Maria ...
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Maurer, Tabea
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McLean, Catriona
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Neuhausen, Susan ...
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Newman, William ...
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Norman, Aaron
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O'Brien, Katie M ...
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Olshan, Andrew F ...
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Olson, Janet E.
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Olsson, Håkan
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Orr, Nick
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Perou, Charles M ...
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Pita, Guillermo
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Polley, Eric C.
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Prentice, Ross L ...
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Rennert, Gad
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Rennert, Hedy S.
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Ruddy, Kathryn J ...
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Sandler, Dale P.
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Saunders, Christ ...
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Schoemaker, Mino ...
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Schöttker, Ben
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Schumacher, Fred ...
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Scott, Christoph ...
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Scott, Rodney J.
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Shu, Xiao-Ou
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Smeets, Ann
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Southey, Melissa ...
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Spinelli, John J ...
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Stone, Jennifer
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Swerdlow, Anthon ...
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Tamimi, Rulla M.
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Taylor, Jack A.
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Troester, Meliss ...
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Vachon, Celine M ...
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van Veen, Elke M ...
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Wang, Xiaoliang
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Weinberg, Claric ...
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Weltens, Carolin ...
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Willett, Walter
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Winham, Stacey J ...
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Wolk, Alicja
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Yang, Xiaohong R ...
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Zheng, Wei
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Ziogas, Argyrios
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Dunning, Alison ...
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Pharoah, Paul D. ...
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Schmidt, Marjank ...
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Kraft, Peter
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Easton, Douglas ...
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Milne, Roger L.
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García-Closas, M ...
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Chang-Claude, Je ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Journal of the N ...
- By the university
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Uppsala University
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Karolinska Institutet