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- Bastankhah, Majid, et al.
(författare)
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A fast-running physics-based wake model for a semi-infinite wind farm
- 2024
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Ingår i: Journal of Fluid Mechanics. - : Cambridge University Press. - 0022-1120 .- 1469-7645. ; 985
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a new generation of fast-running physics-based models to predict the wake of a semi-infinite wind farm, extending infinitely in the lateral direction but with finite size in the streamwise direction. The assumption of a semi-infinite wind farm enables concurrent solving of the laterally averaged momentum equations in both streamwise and spanwise directions. The developed model captures important physical phenomena such as vertical top-down transport of energy into the farm, variable wake recovery rate due to the farm-generated turbulence and also wake deflection due to turbine yaw misalignment and Coriolis force. Of special note is the model's capability to predict and shed light on the counteracting effect of Coriolis force causing wake deflections in both positive and negative directions. Moreover, the impact of wind farm layout configuration on the flow distribution is modelled through a parameter called the local deficit coefficient. Model predictions were validated against large-eddy simulations extending up to 45 km downstream of wind farms. Detailed analyses were performed to study the impacts of various factors such as incoming turbulence, wind farm size, inter-turbine spacing and wind farm layout on the farm wake.
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| 2. |
- Schreiber, Stefan, et al.
(författare)
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Defining Comprehensive Disease Control for use as a Treatment Target for Ulcerative Colitis in Clinical Practice : International Delphi Consensus Recommendations
- 2024
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Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 18:1, s. 91-105
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Treatment of ulcerative colitis (UC) requires a patient-centric, definition of comprehensive disease control that considers improvements in aspects not typically captured by classical landmark trial endpoints. In an international initiative we reviewed aspects of UC that affect patients and/or indicate mucosal inflammation, to achieve consensus on which aspects to combine in a definition of comprehensive disease control, using a modified Delphi process.METHODS: The Delphi panel comprised 12 gastroenterologists and one patient advocate. Two gastroenterologists were elected as chairs and did not vote. To inform statements, we asked 18 patients and the panel members about their experiences of remission and reviewed published literature. Panel members voted on statements anonymously in three rounds, with a live discussion before round 3. Consensus was met if ≥ 67% of the panel agreed. Statements without consensus in rounds 1 and 2 were revised or discarded after round 3.RESULTS: The panel agreed to measure individual patient benefit using a definition of comprehensive disease control that combines aspects currently measured in trials (rectal bleeding, stool frequency, disease-related quality of life, endoscopy, histological inflammatory activity, inflammatory biomarkers, and corticosteroid use), with additional patient-reported symptoms (bowel urgency, abdominal pain, extraintestinal manifestations, fatigue, and sleep disturbance). The panel agreed on scoring systems and thresholds for many aspects.CONCLUSIONS: Using a robust methodology, we defined comprehensive disease control in UC. Next, we will combine the measurement and scoring of these aspects into a multi-component tool and adopt comprehensive disease control as a treatment target in clinical practice and trials.
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