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- de Bruin, LMO, et al.
(författare)
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Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development
- 2018
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 132:3, s. 281-292
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Tidskriftsartikel (refereegranskat)abstract
- Mice with hypomorphic mutations in the Rag1 C-terminal domain are a model of leaky combined immunodeficiency with autoantibodies. Hypomorphic C-terminal domain Rag1 mutations cause repertoire skewing at the earliest stages of B- and T-cell development.
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