| 1. |
- Bargholtz, Chr., et al.
(author)
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The WASA detector facility at CELSIUS
- 2008
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 594:3, s. 339-350
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Journal article (peer-reviewed)abstract
- The WASA 4 pi multidetector system, aimed at investigating light meson production in light ion collisions and eta meson rare decays at the CELSIUS storage ring in Uppsala is presented. A unique feature of the system is the use of hydrogen pellets as internal targets for the first time. A detailed description of the design, together with the anticipated and achieved performance parameters are given. (C) 2008 Elsevier B.V. All rights reserved.
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| 2. |
- Berlowski, M., et al.
(author)
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Measurement of eta meson decays into lepton-antilepton pairs
- 2008
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In: Physical Review D. Particles and fields. - : American Physical Society. - 0556-2821 .- 1089-4918. ; 77:3, s. 032004-
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Journal article (peer-reviewed)abstract
- A search for rare lepton decays of the eta meson was performed using the WASA detector at CELSIUS. Two candidates for double Dalitz decay eta -> e(+)e(-)e(+)e(-) events are reported with a background of 1.3 +/- 0.2 events. This allows to set an upper limit to the branching ratio of 9.7x10(-5) (90% CL). The branching ratio for the decay eta -> e(+)e(-)gamma is determined to (7.8 +/- 0.5(stat)+/- 0.8(syst))x10(-3) in agreement with world average value. An upper limit (90% CL) for the branching ratio for the eta -> e(+)e(-) decay is 2.7x10(-5) and a limit for the sum of the eta ->mu(+)mu(-)mu(+)mu(-) and eta ->pi(+)pi(-)mu(+)mu(-) decays is 3.6x10(-4).
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| 3. |
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| 4. |
- Jacobsson, Benny, 1954-
(author)
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Den sjunde världsdelen : Västgötar och Västergötland 1646-1771. En identitetshistoria
- 2008
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Doctoral thesis (other academic/artistic)abstract
- This thesis considers regional identity in early-modern Sweden, taking its case from the province (landskap) of Västergötland 1646–1771. The aim is to investigate verbal expressions of regional identity. A theory on the construction of regional identity is suggested from the research results, and typological categories of regional identity are established. Contrary to popular concepts of identity being constructed in relation to an outer “other”, it is argued that identity is formed from self-images. Identity is expressed in the first person (I, we), and includes an insider’s perspective of the place occupied. As the thesis shows, the theory of regional identity is substantiated by the duality of the patria-concept. Patria, Fatherland, was employed for the smaller home province as well as for the greater realm. The realm however, always could claim priority to amor patria, Love of the Fatherland. Thus, any construction of regional identity using the neighbouring provinces as a contrasting “other” would have been counter-productive to the construction of the overarching national identity. This manifold patria-concept is of Roman origin, and made its influence through the Latin language well into early-modern time. A great variety of sources in Latin and Swedish have been consulted, including orations and dissertations, minutes of the academic senate and West Geat student nation (Västgöta nation) at Uppsala University, topography, manuscripts and letters. An in-depth study has been made of the writing processes leading up to dissertations and topographical descriptions.
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| 5. |
- Lindberg, Anna-Lena, et al.
(author)
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Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh
- 2008
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In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 106:1, s. 110-20
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Journal article (peer-reviewed)abstract
- Although genetic polymorphisms have been shown to explain some of the large variation observed in the metabolism of inorganic arsenic there may be several other factors playing an important role, e.g. nutrition. The objective of this study was to elucidate the influence of various factors on current arsenic exposure and metabolism in Matlab, a rural area in Bangladesh, where elevated water arsenic concentrations and malnutrition are prevalent. In total 1571 individuals, randomly selected from all inhabitants above 5 years of age, were investigated by measuring arsenic in urine and drinking water. In a subset of 526 randomly selected individuals, arsenic metabolites were speciated using HPLC coupled to inductively coupled plasma mass spectrometry (HPLC-HG-ICPMS). A significant association was observed between arsenic in urine and drinking water (R 2 = 0.41). The contribution to urinary arsenic from arsenic exposure from food and other water sources was calculated to be almost 50 mu g/L. The individuals in the present study had remarkably efficient methylation, in spite of high exposure and prevalence of malnutrition. Gender and age were major factors influencing arsenic metabolism in this population with a median of 77 mu g/L of arsenic in urine (range: 0.5-1994 mu g/L). Women had higher arsenic methylation efficiency than men, but only in childbearing age, supporting an influence of sex hormones. Overall, exposure level of arsenic, gender and age explained at most 30% of the variation in the present study, indicating that genetic polymorphisms are the most important factor influencing the metabolism of inorganic arsenic.
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| 6. |
- Lindberg, A, et al.
(author)
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The Obstructive Lung Disease in Northern Sweden Chronic Obstructive Pulmonary Disease Study: design, the first year participation and mortality
- 2008
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In: The clinical respiratory journal. - 1752-6981. ; 22 Suppl 1, s. 64-71
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Journal article (peer-reviewed)abstract
- BACKGROUND: Most epidemiological data on chronic obstructive pulmonary disease (COPD) are cross-sectional, and the longitudinal course of disease on population bases is incompletely described. AIM: To describe an epidemiological study designed to follow the longitudinal course of disease in chronic obstructive lung disease, COPD, including co-morbidity and mortality and further, to evaluate the impact of COPD on quality of life and health economics. MATERIALS AND METHODS: From the Obstructive Lung Disease in Northern Sweden studies database cohorts I-IV, all subjects with COPD according to the Global Initiative for Chronic Obstructive Lung Disease spirometric criteria, FEV(1)/FVC < 0.70 (n = 993), were identified together with a similar size age- and gender-matched control group. The study population was invited to a yearly examination starting in year 2005. The examinations included structured interview, spirometry with reversibility testing, oxygen saturation and health-related quality of life questionnaires. RESULTS: On the first year, 83% of the population was examined, and the subjects unable to attend the examination were interviewed by telephone. Altogether, 91% of the original study population participated (95% of all subjects were alive at the end of the first year). Mortality was significantly higher among subjects with COPD, 5.1%, compared with controls, 3.0% (P = 0.018). CONCLUSION: The study design including cases of COPD representative of COPD by disease severity in the general population and a similar sized control group, together with a high participation rate in the first study year, creates excellent conditions for evaluating the impact of COPD on population bases, and to follow the longitudinal course of disease in COPD.
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| 7. |
- Lindberg, Bo, 1946
(author)
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Statsräson och moral
- 2008
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In: Förmoderna livshållningar, red. M Lindstedt Cronberg & C. Stenquist, Nordic Academic Press. ; , s. 141-162
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Journal article (other academic/artistic)abstract
- Om hanteringen av moraliska argument i svenska riksrådet under 30-åriga kriget
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| 8. |
- Nix, W Allan, et al.
(author)
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Detection of all known parechoviruses by real-time PCR.
- 2008
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In: Journal of clinical microbiology. - 1098-660X. ; 46:8, s. 2519-24
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Journal article (peer-reviewed)abstract
- The Parechovirus genus of the Picornaviridae family contains two species, Human parechovirus (HPeV) and Ljungan virus (LV). The HPeVs (including the former echoviruses 22 and 23, now HPeV type 1 (HPeV1) and HPeV2, respectively) cause a wide spectrum of disease, including aseptic meningitis, gastroenteritis, encephalitis, acute respiratory illness, and neonatal sepsis-like disease. The LVs were isolated from bank voles in Sweden during a search for an infectious agent linked to fatal myocarditis cases in humans. Because of the decline in use of cell culture and neutralization to investigate enterovirus-like disease, very few laboratories currently have the capability to test for parechoviruses. We have developed a real-time reverse transcription-PCR (RT-PCR) assay for detection of all known members of the genus Parechovirus. The assay targets the conserved regions in the 5' nontranslated region (5'NTR) of the parechovirus genome and can detect both HPeVs and LVs, unlike other published parechovirus 5' NTR assays, which only detect known HPeVs or only LVs. HPeV and LV can be differentiated by sequencing the 5'NTR real-time RT-PCR amplicon, when needed. The assay is approximately 100 times more sensitive than cell culture and may be used to test original clinical specimens. The availability of a broad-specificity PCR method should facilitate the detection of new human parechoviruses, as well as new parechoviruses in other mammalian species, and provide an opportunity to investigate the role of these viruses in human and animal disease.
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| 9. |
- Tolf, Conny, et al.
(author)
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Characterization of polyclonal antibodies against the capsid proteins of Ljungan virus
- 2008
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In: Journal of Virological Methods. - : Elsevier BV. - 0166-0934 .- 1879-0984. ; 150:1-2, s. 34-40
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Journal article (peer-reviewed)abstract
- Ljungan virus (LV) is a suspected human pathogen isolated from voles in Sweden and North America. To enable virus detection and studies of localization and activity of virion proteins, polyclonal antibodies were produced against bacterially expressed capsid proteins of the LV strain, 87-012G. Specific detection of proteins corresponding to viral antigens in lysates of LV infected cells was demonstrated by immunoblotting using each one of the generated polyclonal antibodies. In addition, native viral antigens present in cell culture infected with LV strains 87-012G or 145SLG were detected in ELISA and by immunofluorescence using the antibodies against the VP0 and VP1 proteins. The anti-VP3 antibody did not react with native proteins of the LV virion, suggesting that the VP3 is less potent in evoking humoral response and may have a less exposed orientation in the virus capsid. No activity of the antibodies was observed against the closely related human parechovirus type 1. The polyclonal antibody against the VP1 protein was further used for detection of LV infected myocytes in a mouse model of LV-induced myocarditis. Thus, polyclonal antibodies against recombinant viral capsid proteins enabled detection of natural LV virions by several different immunological methods.
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