| 1. |
- Silventoinen, Karri, et al.
(författare)
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Genetic and environmental variation in educational attainment : an individual-based analysis of 28 twin cohorts
- 2020
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural–geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30–0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900–1949 (a2 = 0.44; 0.41–0.46) than in the later cohorts born in 1950–1989 (a2 = 0.38; 0.36–0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29–0.33 and c2 = 0.34; 0.32–0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.
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| 2. |
- Silventoinen, Karri, et al.
(författare)
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Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts
- 2022
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Ingår i: Scientific Reports. - : Nature Portfolio. - 2045-2322. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.
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| 3. |
- McLeod, Anna F., et al.
(författare)
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The impact of pre-supernova feedback and its dependence on environment
- 2021
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 508:4, s. 5425-5448
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Tidskriftsartikel (refereegranskat)abstract
- Integral field units enable resolved studies of a large number of star-forming regions across entire nearby galaxies, providing insight on the conversion of gas into stars and the feedback from the emerging stellar populations over unprecedented dynamic ranges in terms of spatial scale, star-forming region properties, and environments. We use the Very Large Telescope (VLT) MUSE (Multi Unit Spectroscopic Explorer) legacy data set covering the central 35 arcmin(2) (similar to 12 kpc(2)) of the nearby galaxy NGC 300 to quantify the effect of stellar feedback as a function of the local galactic environment. We extract spectra from emission line regions identified within dendrograms, combine emission line ratios and line widths to distinguish between regions, planetary nebulae, and supernova remnants, and compute their ionized gas properties, gas-phase oxygen abundances, and feedback-related pressure terms. For the regions, we find that the direct radiation pressure (P-dir) and the pressure of the ionized gas (P-HII) weakly increase towards larger galactocentric radii, i.e. along the galaxy's (negative) abundance and (positive) extinction gradients. While the increase of P-HII with galactocentric radius is likely due to higher photon fluxes from lower-metallicity stellar populations, we find that the increase of P-dir is likely driven by the combination of higher photon fluxes and enhanced dust content at larger galactocentric radii. In light of the above, we investigate the effect of increased pre-supernova feedback at larger galactocentric distances (lower metallicities and increased dust mass surface density) on the ISM, finding that supernovae at lower metallicities expand into lower-density environments, thereby enhancing the impact of supernova feedback.
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| 4. |
- Della Bruna, Lorenza, et al.
(författare)
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Stellar feedback in M 83 as observed with MUSE II. Analysis of the H II region population : Ionisation budget and pre-SN feedback
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 666
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Tidskriftsartikel (refereegranskat)abstract
- Context. Energy and momentum injected by young, massive stars into the surrounding gas play an important role in regulating further star formation and in determining the galaxy's global properties. Before supernovae begin to explode, stellar feedback consists of two main processes: radiation pressure and photoionisation.Aims. We study pre-supernova feedback and constrain the leakage of Lyman continuum (LyC) radiation in a sample of similar to 4700 H II regions in the nearby spiral galaxy M 83. We explore the impact that the galactic environment and intrinsic physical properties (metallicity, extinction, and stellar content) have on the early phases of H II region evolution.Methods. We combined VLT/MUSE observations of the ionised gas with young star cluster physical properties derived from HST multiwavelength data. We identified H II regions based on their Hα emission, and cross-matched the sample with planetary nebulae and supernova remnants to assess contaminant sources and identify evolved H II regions. We also spectroscopically identified Wolf-Rayet (WR) stars populating the star-forming regions. We estimated the physical properties of the H II regions (luminosity, size, oxygen abundance, and electron density). For each H II region, we computed the pressure of ionised gas (Pion) and the direct radiation pressure (Pdir) acting in the region, and investigated how they vary with galactocentric distance, with the physical properties of the region, and with the pressure of the galactic environment (PDE). For a subset of similar to 500 regions, we also investigated the link between the pressure terms and the properties of the cluster population (age, mass, and LyC flux). By comparing the LyC flux derived from Hα emission with the one modelled from their clusters and WRs, we furthermore constrained any escape of LyC radiation (fesc).Results. We find that Pion dominates over Pdir by at least a factor of 10 on average over the disk. Both pressure terms are strongly enhanced and become almost comparable in the central starburst region. In the disk (R ≥ 0.15Re), we observe that Pdir stays approximately constant with galactocentric distance. We note that Pdir is positively correlated with an increase in radiation field strength (linked to the negative metallicity gradient in the galaxy), while it decreases in low extinction regions, as is expected if the amount of dust to which the momentum can be imparted decreases. In addition, Pion decreases constantly for increasing galactocentric distances; this trend correlates with the decrease in extinction - indicative of more evolved and thus less compact regions - and with changes in the galactic environment (traced by a decrease in PDE). In general, we observe that H II regions near the centre are underpressured with respect to their surroundings, whereas regions in the rest of the disk are overpressured and hence expanding. We find that regions hosting younger clusters or those that have more mass in young star clusters have a higher internal pressure, indicating that clustered star formation likely plays a dominant role in setting the pressure. Finally, we estimate that only 13% of H II regions hosting young clusters and WR stars have fesc ≥ 0, which suggests that star formation taking place outside young clusters makes a non-negligible contribution to ionising H II regions.
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| 5. |
- Della Bruna, Lorenza, et al.
(författare)
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Stellar feedback in M83 as observed with MUSE I. Overview, an unprecedented view of the stellar and gas kinematics and evidence of outflowing gas
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 660
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Tidskriftsartikel (refereegranskat)abstract
- Context. Young massive stars inject energy and momentum into the surrounding gas, creating a multi-phase interstellar medium (ISM) and regulating further star formation. The main challenge of studying stellar feedback proves to be the variety of scales spanned by this phenomenon, ranging from the immediate surrounding of the stars (H II regions, 10s pc scales) to galactic-wide kiloparsec scales.Aims. We present a large mosaic (3.8 × 3.8 kpc) of the nearby spiral galaxy M83, obtained with the MUSE instrument at ESO Very Large Telescope. The integral field spectroscopy data cover a large portion of the optical disk at a resolution of ∼20 pc, allowing the characterisation of single H II regions while sampling diverse dynamical regions in the galaxy.Methods. We obtained the kinematics of the stars and ionised gas, and compared them with molecular gas kinematics observed in CO(2-1) with the ALMA telescope array. We separated the ionised gas into H II regions and diffuse ionised gas (DIG) and investigated how the fraction of Hα luminosity originating from the DIG (fDIG) varies with galactic radius.Results. We observe that both stars and gas trace the galactic disk rotation, as well as a fast-rotating nuclear component (30″ ≃ 700 pc in diameter), likely connected to secular processes driven by the galactic bar. In the gas kinematics, we observe a stream east of the nucleus (50″ ≃ 1250 pc in size), redshifted with respect to the disk. The stream is surrounded by an extended ionised gas region (1000 × 1600 pc) with enhanced velocity dispersion and a high ionisation state, which is largely consistent with being ionised by slow shocks. We interpret this feature as either the superposition of the disk and an extraplanar layer of DIG, or as a bar-driven inflow of shocked gas. A double Gaussian component fit to the Hα line also reveals the presence of a nuclear biconic structure whose axis of symmetry is perpendicular to the bar. The two cones (20″ ≃ 500 pc in size) appear blue- and redshifted along the line of sight. The cones stand out for having an Hα emission separated by up to 200 km s−1 from that of the disk, and a high velocity dispersion ∼80–200 km s−1. At the far end of the cones, we observe that the gas is consistent with being ionised by shocks. These features had never been observed before in M83; we postulate that they are tracing a starburst-driven outflow shocking into the surrounding ISM. Finally, we obtain fDIG ∼ 13% in our field of view, and observe that the DIG contribution varies radially between 0.8 and 46%, peaking in the interarm region. We inspect the emission of the H II regions and DIG in ‘BPT’ diagrams, finding that in H II regions photoionisation accounts for 99.8% of the Hα flux, whereas the DIG has a mixed contribution from photoionisation (94.9%) and shocks (5.1%).
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| 6. |
- Ferro, Lorenza, 1989-, et al.
(författare)
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DNA metabarcoding reveals microbial community dynamics in a microalgae-based municipal wastewater treatment open photobioreactor
- 2020
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Ingår i: Algal Research. - : Elsevier BV. - 2211-9264. ; 51
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Tidskriftsartikel (refereegranskat)abstract
- Controlling the growth of desired algal strains in microalgal-based wastewater treatment systems is challenging, and understanding the dynamics and interactions in the system is vital for proper management. A pilot-scale open photobioreactor located in Northern Sweden, was inoculated with the culture collection strain Scenedesmus dimorphus UTEX 417, which had been grown in Nordic climate for 8 years. The microbial diversity of eukaryotic and prokaryotic communities and their seasonal dynamics were revealed throughout the growth period by high-throughput sequencing of 18S and 16S rRNA genes and correlated with various environmental factors. S. dimorphus was stable in batch culture, but other microalgae appeared during semi-batch mode and co-dominated the system as a consequence of predation by zooplankton. Desmodesmus, Pseudocharaciopsis, Chlorella, Characium and Oocystis were the main microalgal species co-occurring in the system, with Characium and Chlorella acting as main competitors to Scenedesmus. Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria were the most abundant bacterial phyla, some of which showing significant positive or negative influence on Scenedesmus growth over time. Light, temperature, dissolved oxygen, pH and nutrients concentrations were found to have significant influence on the bacterial and/or zooplanktonic community changes.
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| 7. |
- Hannon, Stephen, et al.
(författare)
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H α morphologies of star clusters in 16 LEGUS galaxies : Constraints on H II region evolution time-scales
- 2022
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 512:1, s. 1294-1316
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Tidskriftsartikel (refereegranskat)abstract
- The analysis of star cluster ages in tandem with the morphology of their H II regions can provide insight into the processes that clear a cluster’s natal gas, as well as the accuracy of cluster ages and dust reddening derived from Spectral Energy Distribution (SED) fitting. We classify 3757 star clusters in 16 nearby galaxies according to their H α morphology (concentrated, partially exposed, no emission), using Hubble Space Telescope (HST) imaging from the Legacy ExtraGalactic Ultraviolet Survey (LEGUS). We find: (1) The mean SED ages of clusters with concentrated (1–2 Myr) and partially exposed H II region morphologies (2–3 Myr) indicate a relatively early onset of gas clearing and a short (1–2 Myr) clearing time-scale. (2) The reddening of clusters can be overestimated due to the presence of red supergiants, which is a result of stochastic sampling of the IMF in low mass clusters. (3) The age-reddening degeneracy impacts the results of the SED fitting – out of 1408 clusters with M* ≥ 5000 M⊙, we find that at least 46 (3 per cent) have SED ages which appear significantly underestimated or overestimated based on H α and their environment, while the total percentage of poor age estimates is expected to be several times larger. (4) Lastly, we examine the dependence of the morphological classifications on spatial resolution. At HST resolution, our conclusions are robust to the distance range spanned by the sample (3–10 Mpc). However, analysis of ground-based H α images shows that compact and partially exposed morphologies frequently cannot be distinguished from each other.
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| 8. |
- Long, Knox S., et al.
(författare)
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Supernova Remnants in M83 as Observed with MUSE
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 929:2
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe a new study of the supernova remnants (SNRs) and SNR candidates in nearby face-on spiral galaxy M83, based primarily on MUSE integral field spectroscopy. Our revised catalog of SNR candidates in M83 has 366 objects, 81 of which are reported here for the first time. Of these, 229 lie within the MUSE observation region, 160 of which have spectra with [S ii]:Hα ratios exceeding 0.4, the value generally accepted as confirmation that an emission nebula is shock-heated. Combined with 51 SNR candidates outside the MUSE region with high [S ii]:Hα ratios, there are 211 spectroscopically confirmed SNRs in M83, the largest number of confirmed SNRs in any external galaxy. MUSE's combination of relatively high spectral resolution and broad wavelength coverage has allowed us to explore two other properties of SNRs that could serve as the basis of future SNR searches. Specifically, most of the objects identified as SNRs on the basis of [S ii]:Hα ratios exhibit more velocity broadening and lower ratios of [S iii]:[S ii] emission than H ii regions. A search for nebulae with the very broad emission lines expected from young, rapidly expanding remnants revealed none, except for the previously identified B12-174a. The SNRs identified in M83 are, with few exceptions, middle-aged interstellar medium (ISM) dominated ones. Smaller-diameter candidates show a larger range of velocity broadening and a larger range of gas densities than the larger-diameter objects, as expected if the SNRs expanding into denser gas brighten and then fade from view at smaller diameters than those expanding into a more tenuous ISM.
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| 9. |
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| 10. |
- Rubio, Isabel T., et al.
(författare)
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EUSOMA quality indicators for non-metastatic breast cancer : An update
- 2024
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Ingår i: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 198
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionQuality care in breast cancer is higher if patients are treated in a Breast Center with a dedicated and specialized multidisciplinary team. Quality control is an essential activity to ensure quality care, which has to be based on the monitoring of specific quality indicators. Eusoma has proceeded with the up-dating of the 2017 Quality indicators for non-metastatic breast cancer based on the new diagnostic, locoregional and systemic treatment modalities.MethodsTo proceed with the updating, EUSOMA setup a multidisciplinary working group of BC experts and patients’ representatives. It is a comprehensive set of QIs for early breast cancer care, which are classified as mandatory, recommended, or observational. For the first time patient reported outcomes (PROMs) have been included. As used in the 2017 EUSOMA QIs, evidence levels were based on the short version of the US Agency for Healthcare Research and Quality.ResultsThis is a set of quality indicators representative for the different steps of the patient pathway in non-metastatic setting, which allow Breast Centres to monitor their performance with referring standards, i.e minimum standard and target.ConclusionsMonitoring these Quality Indicators, within the Eusoma datacentre will allow to have a state of the art picture at European Breast Centres level and the development of challenging research projects.
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