Search: (WFRF:(Luisa Brandi Maria)) pers:(McGuigan Fiona E A)
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The association bet...
The association between common vitamin D receptor gene variations and osteoporosis : a participant-level meta-analysis
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- Uitterlinden, André G (author)
- Erasmus University Medical Center
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Ralston, Stuart H (author)
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Brandi, Maria Luisa (author)
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show more...
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Carey, Alisoun H (author)
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Grinberg, Daniel (author)
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Langdahl, Bente L (author)
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Lips, Paul (author)
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Lorenc, Roman (author)
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Obermayer-Pietsch, Barbara (author)
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Reeve, Jonathan (author)
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Reid, David M (author)
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Amedei, Antonietta (author)
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Amidei, Antonietta (author)
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Bassiti, Amelia (author)
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Bustamante, Mariona (author)
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Husted, Lise Bjerre (author)
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Diez-Perez, Adolfo (author)
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Dobnig, Harald (author)
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Dunning, Alison M (author)
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Enjuanes, Anna (author)
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Fahrleitner-Pammer, Astrid (author)
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Fang, Yue (author)
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Karczmarewicz, Elzbieta (author)
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Kruk, Marcin (author)
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van Leeuwen, Johannes P T M (author)
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Mavilia, Carmelo (author)
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van Meurs, Joyce B J (author)
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Mangion, Jon (author)
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- McGuigan, Fiona E A (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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Pols, Huibert A P (author)
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Renner, Wilfried (author)
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Rivadeneira, Fernando (author)
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van Schoor, Natasja M (author)
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Scollen, Serena (author)
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Sherlock, Rachael E (author)
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Ioannidis, John P A (author)
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(creator_code:org_t)
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- 2006
- 2006
- English 10 s.
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In: Annals of Internal Medicine. - 0003-4819. ; 145:4, s. 255-264
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Abstract
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- BACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear.OBJECTIVE: To evaluate the relation between VDR polymorphisms, BMD, and fractures.DESIGN: Prospective multicenter large-scale association study.SETTING: The Genetic Markers for Osteoporosis consortium, involving 9 European research teams.PARTICIPANTS: 26,242 participants (18,405 women).MEASUREMENTS: Cdx2 promoter, FokI, BsmI, ApaI, and TaqI polymorphisms; BMD at the femoral neck and the lumbar spine by dual x-ray absorptiometry; and fractures.RESULTS: Comparisons of BMD at the lumbar spine and femoral neck showed nonsignificant differences less than 0.011 g/cm2 for any genotype with or without adjustments. A total of 6067 participants reported a history of fracture, and 2088 had vertebral fractures. For all VDR alleles, odds ratios for fractures were very close to 1.00 (range, 0.98 to 1.02) and collectively the 95% CIs ranged from 0.94 (lowest) to 1.07 (highest). For vertebral fractures, we observed a 9% (95% CI, 0% to 18%; P = 0.039) risk reduction for the Cdx2 A-allele (13% risk reduction in a dominant model).LIMITATIONS: The authors analyzed only selected VDR polymorphisms. Heterogeneity was detected in some analyses and may reflect some differences in collection of fracture data across cohorts. Not all fractures were related to osteoporosis.CONCLUSIONS: The FokI, BsmI, ApaI, and TaqI VDR polymorphisms are not associated with BMD or with fractures, but the Cdx2 polymorphism may be associated with risk for vertebral fractures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Adult
- Aged
- Bone Density
- CDX2 Transcription Factor
- Deoxyribonucleases, Type II Site-Specific
- Female
- Fractures, Bone
- Genotype
- Haplotypes
- Homeodomain Proteins
- Humans
- Male
- Middle Aged
- Osteoporosis
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Prospective Studies
- Receptors, Calcitriol
- Journal Article
- Meta-Analysis
- Multicenter Study
- Research Support, Non-U.S. Gov't
Publication and Content Type
- art (subject category)
- ref (subject category)
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Uitterlinden, An ...
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Ralston, Stuart ...
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Brandi, Maria Lu ...
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Carey, Alisoun H
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Grinberg, Daniel
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Langdahl, Bente ...
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show more...
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Lips, Paul
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Lorenc, Roman
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Obermayer-Pietsc ...
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Reeve, Jonathan
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Reid, David M
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Amedei, Antoniet ...
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Amidei, Antoniet ...
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Bassiti, Amelia
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Bustamante, Mari ...
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Husted, Lise Bje ...
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Diez-Perez, Adol ...
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Dobnig, Harald
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Dunning, Alison ...
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Enjuanes, Anna
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Fahrleitner-Pamm ...
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Fang, Yue
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Karczmarewicz, E ...
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Kruk, Marcin
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van Leeuwen, Joh ...
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Mavilia, Carmelo
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van Meurs, Joyce ...
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Mangion, Jon
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McGuigan, Fiona ...
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Pols, Huibert A ...
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Renner, Wilfried
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Rivadeneira, Fer ...
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van Schoor, Nata ...
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Scollen, Serena
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Sherlock, Rachae ...
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Ioannidis, John ...
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and Orthopaedics
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Lund University