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- Gerhardsson, Lars, et al.
(författare)
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Cadmium, copper and zinc in tissues of deceased copper smelter workers
- 2002
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Ingår i: Journal of Trace Elements in Medicine and Biology. - 1878-3252. ; 16:4, s. 261-266
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Tidskriftsartikel (refereegranskat)abstract
- Workers at a copper and lead smelter in northern Sweden have a multifactorial exposure to a number of heavy metals. The concentrations of cadmium, copper and zinc in Liver, Lung, kidney and brain tissues have been deters mined by atomic absorption spectrometry in 32 deceased tong-term exposed male lead smelter workers, and compared with those of 10 male controls. Furthermore, copper and zinc Levels in hair and nails were determined by energy-dispersive X-ray fluorescence. The highest cadmium concentrations among both workers and controls were observed in kidney, followed in order by liver, lung and brain. The levels in kidney, Liver and Lung were all significantly higher in the workers than in the controls (p < 0.03). Among the workers relatively strong positive correlations (p < 0.03) were observed between cadmium concentrations in liver and lung, liver and kidney, liver and brain, and lung and brain. In the exposed workers a positive correlation was observed between cadmium and zinc concentrations in the kidney (r(s) = 0.38; p = 0.034). This is probably mainly due to the protein metallothionein, which is stored in the kidney, binding equimolar amounts of these two metals. The highest concentrations of copper were found in hair and nails among both workers and controls, followed in order by liver, brain, kidney and Lung. The tissue concentrations of copper in brain, Lung and kidney were all significantly higher among the smelter workers than in the controls (p less than or equal to 0.036). Copper Levels in lung and age at time of death were positively correlated among the exposed workers (r(s) = 0.39; p = 0.029). In the same group, positive correlations between copper and zinc concentrations in kidney (r(s) = 0.45; p = 0.009) and nails (r(s) = 0.68; p < 0.001) were also observed, reflecting possible biological interactions between these two metals. Among both workers and controls, the highest zinc concentrations were found in hair, followed in order by nails, liver, kidney, brain and lung. Significantly higher tissue concentrations among the workers as compared with the reference group were noted in kidney, liver and brain (p &LE; 0.033). Neither copper nor zinc concentrations in hair and nails seemed to provide a useful measure of the trace element status of the smelter workers.Workers at a copper and lead smelter in northern Sweden have a muttifactodal exposure to a number of heavy metals. The concentrations of cadmium, copper and zinc in Liver, Lung, kidney and brain tissues have been deters mined by atomic absorption spectrometry in 32 deceased tong-term exposed male lead smelter workers, and compared with those of 10 male controls. Furthermore, copper and zinc Levels in hair and nails were determined by energy-dispersive X-ray fluorescence. The highest cadmium concentrations among both workers and controls were observed in kidney, followed in order by liver, lung and brain. The levels in kidney, Liver and Lung were all significantly higher in the workers than in the controls (p < 0.03). Among the workers reLativety strong positive correlations (p < 0.03) were observed between cadmium concentrations in liver and lung, liver and kidney, liver and brain, and lung and brain. In the exposed workers a positive correlation was observed between cadmium and zinc concentrations in the kidney (r, = 0.38; p = 0.034). This is probably mainly due to the protein meta llothionei n, which is stored in the kidney, binding equimolar amounts of these two metals. The highest concentrations of copper were found in hair and nails among both workers and controls, followed in order by liver, brain, kidney and Lung. The tissue concentrations of copper in brain, Lung and kidney were all significantLy higher among the smelter workers than in the controls (p &LE;0.036). Copper Levels in lung and age at time of death were positively correlated among the exposed workers (r(s) = 0.39; p = 0.029). In the same group, positive correlations between copper and zinc concentrations in kidney (r(s) = 0.45; p = 0.009) and nails (r(x) = 0.68; p < 0.001) were also observed, reflecting possible biological interactions between these two metals. Among both workers and controls, the highest zinc concentrations were found in hair, followed in order by naits, liver, kidney, brain and lung. Significantly higher tissue concentrations among the workers as compared with the reference group were noted in kidney, liver and brain (p < 0.033). Neither copper nor zinc concentrations in hair and nails seemed to provide a useful measure of the trace element status of the smelter workers.
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- Jonsson, S W, et al.
(författare)
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Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis
- 2001
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Ingår i: Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 28, s. 2597-2602
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To measure the extent of atherosclerosis in patients with rheumatoid arthritis (RA) with a disease duration of considerable length, and in age and sex matched individuals. Methods. Thirty-nine patients with RA (30 women, 9 men) with disease onset occurring between 1974 and 1978, and less than 65 years of age at the time of investigation, were enrolled together with 39 sex and age matched controls. Quantitative measurement of intima-media thickness (IMT) and semiquantitative assessment of the presence of plaque were undertaken by B-mode ultrasound of the common carotid artery (CCA-IMT) and the common femoral artery on the right-hand side. Echo Doppler cardiography was performed with an Accuson Aspen. The results were related to disease activity variables and accumulated disease activity, to lipid levels [i.e., cholesterol, high density lipoproteins, low density lipoproteins, triglycerides (TG)], to hemostatic factors [tissue plasminogen activator antigen (tPAag), plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF)], and to soluble adhesion molecules (sICAM-1 and sE-selectin). Results. Patients with RA had higher maximal and mean IMT values compared with controls. The difference concerning mean CCA-IMT reached statistical significance in patients with RA and correlated significantly with lipids (cholesterol, LDL, LDL/HDL ratio, TG) and tPAag. The prevalence of plaques, as well as of aortic cusp sclerosis, was higher in RA but only the difference in aortic cusp sclerosis was statistically significant. Patients with plaques had significantly higher levels of lipids (cholesterol, LDL, LDL/HDL ratio) than patients without plaques, while patients with cusp sclerosis had significantly higher cholesterol and TG levels. sICAM-1 was significantly higher both in patients with plaques and in those with aortic cusp sclerosis compared to patients without. Conclusion. Our results suggest an accelerated atherosclerosis in patients with RA that is related mainly to lipid levels.
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- Lundstrom, S, et al.
(författare)
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Symptoms in advanced cancer: relationship to endogenous cortisol levels
- 2003
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Ingår i: Palliative medicine. - : SAGE Publications. - 0269-2163 .- 1477-030X. ; 17:6, s. 503-508
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Tidskriftsartikel (refereegranskat)abstract
- We investigated a possible relationship between levels of endogenous cortisol and severity of different symptoms in patients with advanced cancer. Twenty-three patients with predominantly gastrointestinal cancer, recruited in a palliative care unit, entered the study. Urinary free cortisol (UFC) was measured together with demographic data, blood parameters, tumour burden, concurrent illness, medication, nutritional status and quality of life. Significant positive correlations were found between levels of endogenous cortisol and appetite loss, fatigue and nausea/vomiting. The findings support the view of a chronic stress condition in advanced cancer. Interaction between cytokines and the hypothalamicpituitary-adrenal (HPA) axis may also be important in the interpretation of the results.
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- Okada, S, et al.
(författare)
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Synthesis and investigation of large crystals of (Cr1-xTMx)(3)B-4 with TM = Ti, V, Nb, Ta, Mo, and W
- 2000
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Ingår i: JOURNAL OF SOLID STATE CHEMISTRY. - : ACADEMIC PRESS INC. - 0022-4596. ; 154:1, s. 45-48
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Tidskriftsartikel (refereegranskat)abstract
- Single crystals of the ternary borides (Cr1-xTMx)(3)B-4 (TM = Ti, V, Nh, Ta, Mo, W) were grown by the flux method using molten aluminum as a solvent, The substances were subjected to chemical analyses and measurements of the unit cell parameters. Crystals
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