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Perturbed Insulin-l...
Perturbed Insulin-like Growth Factor-1 (IGF-1) and IGF Binding Protein-3 Are Not Associated with Chronic Widespread Pain in Men: Results from the European Male Ageing Study.
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McBeth, John (author)
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Tajar, Abdelouahid (author)
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O'Neill, Terence W (author)
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Macfarlane, Gary J (author)
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Pye, Stephen R (author)
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Bartfai, Gyorgy (author)
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Boonen, Steven (author)
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Bouillon, Roger (author)
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Casanueva, Felipe (author)
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Finn, Joseph D (author)
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Forti, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S (author)
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Huhtaniemi, Ilpo T (author)
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Kula, Krzysztof (author)
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Lean, Michael E J (author)
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Pendleton, Neil (author)
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Punab, Margus (author)
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Silman, Alan J (author)
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Vanderschueren, Dirk (author)
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Wu, Frederick C W (author)
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(creator_code:org_t)
- 2009-10-15
- 2009
- English.
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In: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 36, s. 2523-2530
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://www.jrheum.o...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
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- OBJECTIVE: To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. METHODS: The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. RESULTS: A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. CONCLUSION: Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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McBeth, John
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Tajar, Abdelouah ...
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O'Neill, Terence ...
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Macfarlane, Gary ...
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Pye, Stephen R
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Bartfai, Gyorgy
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show more...
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Boonen, Steven
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Bouillon, Roger
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Casanueva, Felip ...
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Finn, Joseph D
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E ...
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Pendleton, Neil
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Punab, Margus
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Silman, Alan J
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Vanderschueren, ...
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Wu, Frederick C ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Journal of Rheum ...
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Lund University