Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link

• Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent amechanistic link between A beta/tau deposition after TBI and the development of post concussive syndrome, dementia and chronic traumatic encephalopathy (CTE). In addition to debilitating acute effects, TBI-induced neurovascular injuries accelerate amyloid beta (A beta) production and perivascular accumulation, arterial stiffness, tau hyperphosphorylation and tau/A beta-induced blood brain barrier damage, giving rise to a deleterious feed-forward loop. We postulate that TBI can initiate cerebrovascular pathology, which is causally involved in the development of multiple forms of neurodegeneration including AD-like dementias. In this review, we will explore hownovel biomarkers, animal and human studies with a focus on cerebrovascular dysfunction are contributing to the understanding of the consequences of TBI on the development of AD-like pathology.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Traumatic brain injury

Alzheimer's disease

Cerebrovascular pathology

Biomarkers

A beta

Tau

white-matter damage

cerebral amyloid angiopathy

endothelial

nitric-oxide

total tau

cerebrospinal-fluid

blood biomarkers

murine

model

mouse model

cognitive impairment

neurovascular unit

General & Internal Medicine

Research & Experimental Medicine

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)