Search: (WFRF:(Mentch Frank)) pers:(Standl Marie)
> (2016) >
A genome-wide assoc...
A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.
-
Bustamante, Mariona (author)
-
Standl, Marie (author)
-
Bassat, Quique (author)
-
show more...
-
Vilor-Tejedor, Natalia (author)
-
Medina-Gomez, Carolina (author)
-
Bonilla, Carolina (author)
-
Ahluwalia, Tarunveer S (author)
-
- Bacelis, Jonas, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
-
Bradfield, Jonathan P (author)
-
Tiesler, Carla M T (author)
-
Rivadeneira, Fernando (author)
-
Ring, Susan (author)
-
Vissing, Nadja H (author)
-
Fink, Nadia R (author)
-
Jugessur, Astanand (author)
-
Mentch, Frank D (author)
-
Ballester, Ferran (author)
-
Kriebel, Jennifer (author)
-
Kiefte-de Jong, Jessica C (author)
-
Wolsk, Helene M (author)
-
Llop, Sabrina (author)
-
Thiering, Elisabeth (author)
-
Beth, Systke A (author)
-
Timpson, Nicholas J (author)
-
Andersen, Josefine (author)
-
Schulz, Holger (author)
-
Jaddoe, Vincent W V (author)
-
Evans, David M (author)
-
Waage, Johannes (author)
-
Hakonarson, Hakon (author)
-
Grant, Struan F A (author)
-
- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
-
Bønnelykke, Klaus (author)
-
Bisgaard, Hans (author)
-
Davey Smith, George (author)
-
Moll, Henriette A (author)
-
Heinrich, Joachim (author)
-
Estivill, Xavier (author)
-
Sunyer, Jordi (author)
-
show less...
-
(creator_code:org_t)
- 2016-08-23
- 2016
- English.
-
In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:18, s. 4127-4142
- Related links:
-
https://academic.oup...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- More than a million childhood diarrhoeal episodes occur worldwide each year, and in developed countries a considerable part of them are caused by viral infections. In this study, we aimed to search for genetic variants associated with diarrhoeal disease in young children by meta-analyzing genome-wide association studies, and to elucidate plausible biological mechanisms. The study was conducted in the context of the Early Genetics and Lifecourse Epidemiology (EAGLE) consortium. Data about diarrhoeal disease in two time windows (around 1 year of age and around 2 years of age) was obtained via parental questionnaires, doctor interviews or medical records. Standard quality control and statistical tests were applied to the 1000 Genomes imputed genotypic data. The meta-analysis (N=5758) followed by replication (N=3784) identified a genome-wide significant association between rs8111874 and diarrhoea at age 1 year. Conditional analysis suggested that the causal variant could be rs601338 (W154X) in the FUT2 gene. Children with the A allele, which results in a truncated FUT2 protein, had lower risk of diarrhoea. FUT2 participates in the production of histo-blood group antigens and has previously been implicated in the susceptibility to infections, including Rotavirus and Norovirus Gene-set enrichment analysis suggested pathways related to the histo-blood group antigen production, and the regulation of ion transport and blood pressure. Among others, the gastrointestinal tract, and the immune and neuro-secretory systems were detected as relevant organs. In summary, this genome-wide association meta-analysis suggests the implication of the FUT2 gene in diarrhoeal disease in young children from the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bustamante, Mari ...
-
Standl, Marie
-
Bassat, Quique
-
Vilor-Tejedor, N ...
-
Medina-Gomez, Ca ...
-
Bonilla, Carolin ...
-
show more...
-
Ahluwalia, Tarun ...
-
Bacelis, Jonas, ...
-
Bradfield, Jonat ...
-
Tiesler, Carla M ...
-
Rivadeneira, Fer ...
-
Ring, Susan
-
Vissing, Nadja H
-
Fink, Nadia R
-
Jugessur, Astana ...
-
Mentch, Frank D
-
Ballester, Ferra ...
-
Kriebel, Jennife ...
-
Kiefte-de Jong, ...
-
Wolsk, Helene M
-
Llop, Sabrina
-
Thiering, Elisab ...
-
Beth, Systke A
-
Timpson, Nichola ...
-
Andersen, Josefi ...
-
Schulz, Holger
-
Jaddoe, Vincent ...
-
Evans, David M
-
Waage, Johannes
-
Hakonarson, Hako ...
-
Grant, Struan F ...
-
Jacobsson, Bo, 1 ...
-
Bønnelykke, Klau ...
-
Bisgaard, Hans
-
Davey Smith, Geo ...
-
Moll, Henriette ...
-
Heinrich, Joachi ...
-
Estivill, Xavier
-
Sunyer, Jordi
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Human molecular ...
- By the university
-
University of Gothenburg