| 1. |
-
- 2019
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Kraemer, B. K., et al.
(författare)
-
Efficacy of Prolonged- and Immediate-release Tacrolimus in Kidney Transplantation : A Pooled Analysis of Two Large, Randomized, Controlled Trials
- 2017
-
Ingår i: Transplantation Proceedings. - : Elsevier BV. - 0041-1345 .- 1873-2623. ; 49:9, s. 2040-2049
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Two large, prospective studies (12-03; OSAKA) compared the efficacy and tolerability of prolonged-release versus immediate-release tacrolimus in kidney transplant patients also receiving mycophenolate mofetil and low-dose corticosteroids (without induction therapy). Methods. Data were combined into one database to compare results over 24 weeks using 3 alternative endpoints: biopsy-confirmed acute rejection (BCAR); the Food and Drug Administration composite endpoint (graft loss, SCAR, and loss to follow-up), and the European Medicines Agency composite endpoint (graft loss, BCAR, and graft dysfunction). The 95% confidence intervals were calculated (10% noninferiority margin). Results. Overall, 633 patients received prolonged-release tacrolimus (12-03, n = 331; OSAKA, n = 302) and 645 received immediate-release tacrolimus (n = 336; n = 309). Baseline characteristics were comparable. Proportionately more patients receiving prolonged-release tacrolimus had trough levels of 5-15 ng/mL on day 1 (60.8%) and 2 (56.6%) versus immediate-release tacrolimus (42.5% and 43.9%, respectively, both P < .001). Efficacy of prolonged-release and immediate-release tacrolimus were similar as assessed by BCAR (13.9% vs 14.1%, respectively), European Medicines Agency composite endpoint (40.3% vs 38.3%) and US Food and Drug Administration composite endpoint (21.5% vs 19.8%). Conclusions. Novel efficacy endpoints as required by the European Medicines Agency and US Food and Drug Administration demonstrate noninferiority of prolonged-release versus immediate-release tacrolimus. Significantly more patients treated with prolonged release tacrolimus versus immediate-release tacrolimus achieved trough levels of 5 to 15 ng/mL early after transplantation.
|
|
| 5. |
- Mourad, Khaldoon A., et al.
(författare)
-
Culture of Medicinal Plants in the city of Fortaleza as a proposal for the sustainable development of the municipality
- 2015
-
Ingår i: International Journal of Life Science and Engineering. ; 1:4, s. 177-182
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Medicinal plants cultivation has grown all over the world. This paper studies the role of Medicinal plants cultivation in sustainable development. The research takes the city of Fortaleza in Brazil as a case study. The results show that the proposed Living Pharmacy Program, which has been implanting for more than 20 years since 1990 in the municipality of Fortaleza, is enlarging the access of the population to the medicinal plants and physiotherapeutic medications, awakening their ecological conscience and thus contributing to economic and sustainable development of the municipality.
|
|
| 6. |
- Ng’ang’a, Gathagu John, et al.
(författare)
-
UNCERTAINTY ANALYSIS AND CALIBRATION OF SWAT MODEL FOR ESTIMATING IMPACTS OF CONSERVATION METHODS ON STREAMFLOW AND SEDIMENT YIELD IN THIKA RIVER CATCHMENT, KENYA
- 2018
-
Ingår i: International Journal of Hydrology Research. - 2576-4454. ; 3:1, s. 1-11
-
Tidskriftsartikel (refereegranskat)abstract
- Despite their imperative role in water resources management, distributed hydrological models like SWAT require calibration that can be challenging due to uncertainties of parameters involved. Prior to modelling of hydrological processes, these parameters and their uncertainty range need to be identified. The objective of this study was to conduct uncertainty analysis of hydrological processes and to calibrate the Soil and Water Assessment Tool (SWAT) for stream flow and sediment yield modelling in Thika River catchment. Sequential Uncertainty Fitting program (SUFI-2) was used to conduct sensitivity and uncertainty analysis. Stream flow was calibrated and validated between the years 1998 to 2013 for gauging stations 4CB05 and 4CB04. Manual sediments calibration was achieved by constraining the MUSLE parameters using the bathymetric survey data. Two uncertainty indices, p and r factor, were obtained as 0.72 and 0.65, 0.65 and 0.45 during calibration and validation, respectively. Statisticalperformance indicators showed a good match between the observed and simulated values which indicated that the model was well calibrated for simulation of stream flow and sediments yield in the catchment.
|
|
