| 1. |
- Aalto, Susanne, 1964, et al.
(författare)
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Detection of HCN, HCO+, and HNC in the Mrk 231 molecular outflow. Dense molecular gas in the AGN wind
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 537, s. 44-51
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Tidskriftsartikel (refereegranskat)abstract
- We obtained high-resolution (1.''55 × 1.''28) observations of HCN, HCO+, HNC 1-0 and HC3N 10-9 of the ultraluminous galaxy (ULIRG) Mrk 231 with the IRAM Plateau de Bure Interferometer.Results: We detect luminous emission from HCN, HCO+ and HNC 1-0 in the QSO ULIRG Mrk 231. All three lines show broad line wings - which are particularly prominent for HCN. Velocities are found to be similar ( ≈ ± 750 km s-1) to those found for CO 1-0. This is the first time bright HCN, HCO+ and HNC emission has been detected in a large-scale galactic outflow. We find that both the blue- and red-shifted line wings are spatially extended by at least 0.''75 (>700 pc) in a north-south direction. The line wings are brighter (relative to the line center intensity) in HCN than in CO 1-0 and line ratios suggest that the molecular outflow consists of dense (n > 104 cm-3) and clumpy gas with a high HCN abundance X(HCN) > 10-8. These properties are consistent with the molecular gas being compressed and fragmented by shocks in the outflow. Alternatively, HCN is instead pumped by mid-IR continuum, but we propose that this effect is not strong for the spatially extended outflowing gas. In addition, we find that the rotation of the main disk, in east-west direction, is also evident in the HCN, HCO+ and HNC line emission. An unexpectedly bright HC3N 10-9 line is detected inside the central 400 pc of Mrk 231. This HC3N emission may emerge from a shielded, dust-enshrouded region within the inner 40-50 pc where the gas is heated to high temperatures (200-300 K) by the AGN.
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| 2. |
- Aalto, Susanne, 1964, et al.
(författare)
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Winds of change - a molecular outflow in NGC 1377? The anatomy of an extreme FIR-excess galaxy
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 546, s. Article Number: A68-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. Our goal was to investigate the molecular gas distribution and kinematics in the extreme far-infrared (FIR) excess galaxy NGC 1377 and to address the nature and evolutionary status of the buried source. Methods. We used high-(0.'' 65 x 0.'' 52, (65 x 52 pc)) and low-(4.'' 88 x 2.'' 93) resolution SubMillimeter Array (SMA) observations to image the (CO)-C-12 and (CO)-C-13 2-1 line emission. Results. We find bright, complex (CO)-C-12 2-1 line emission in the inner 400 pc of NGC 1377. The (CO)-C-12 2-1 line has wings that are tracing a kinematical component that appears to be perpendicular to the component traced by the line core. Together with an intriguing X-shape of the integrated intensity and dispersion maps, this suggests that the molecular emission of NGC 1377 consists of a disk-outflow system. Lower limits to the molecular mass and outflow rate are M-out(H-2) > 1 x 10(7) M-circle dot and (M) over dot > 8 M-circle dot yr(-1). The age of the proposed outflow is estimated to be 1.4 Myr, the extent to be 200 pc and the outflow speed to be V-out = 140 km s(-1). The total molecular mass in the SMA map is estimated to M-tot(H-2) = 1.5 x 10(8) M-circle dot (on a scale of 400 pc) while in the inner r = 29 pc the molecular mass is M-core(H-2) = 1.7 x 10(7) M-circle dot with a corresponding H-2 column density of N(H-2) = 3.4 x 10(23) cm(-2) and an average (CO)-C-12 2-1 brightness temperature of 19 K. (CO)-C-13 2-1 emission is found at a factor 10 fainter than (CO)-C-12 in the low-resolution map while (CO)-O-18 2-1 remains undetected. We find weak 1 mm continuum emission of 2.4 mJy with spatial extent less than 400 pc. Conclusions. Observing the molecular properties of the FIR-excess galaxy NGC 1377 allows us to probe the early stages of nuclear activity and the onset of feedback in active galaxies. The age of the outflow supports the notion that the current nuclear activity is young - a few Myr. The outflow may be powered by radiation pressure from a compact, dust enshrouded nucleus, but other driving mechanisms are possible. The buried source may be an active galactic nucleus (AGN) or an extremely young (1 Myr) compact star-burst. Limitations on size and mass lead us to favor the AGN scenario, but additional studies are required to settle this question. In either case, the wind with its implied mass outflow rate will quench the nuclear power source within the very short time of 5-25 Myr. It is possible, however, that the gas is unable to escape the galaxy and may eventually fall back onto NGC 1377 again.
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| 3. |
- Arora, Deepika, et al.
(författare)
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Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells : FLT3 ITD sustains high levels of DUSP6 expression
- 2012
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Ingår i: Cell Communication and Signaling. - 1478-811X. ; 10:1, s. 19-
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Tidskriftsartikel (refereegranskat)abstract
- Protein-tyrosine phosphatases (PTPs) are important regulators of cellular signaling and changes in PTP activity can contribute to cell transformation. Little is known about the role of PTPs in Acute Myeloid Leukemia (AML). The aim of this study was therefore to establish a PTP expression profile in AML cells and to explore the possible role of FLT3 ITD (Fms-like tyrosine kinase 3 with internal tandem duplication), an important oncoprotein in AML for PTP gene expression. PTP mRNA expression was analyzed in AML cells from patients and in cell lines using a RT-qPCR platform for detection of transcripts of 92 PTP genes. PTP mRNA expression was also analyzed based on a public microarray data set for AML patients. Highly expressed PTPs in AML belong to all PTP subfamilies. Very abundantly expressed PTP genes include PTPRC, PTPN2, PTPN6, PTPN22, DUSP1, DUSP6, DUSP10, PTP4A1, PTP4A2, PTEN, and ACP1. PTP expression was further correlated with the presence of FLT3 ITD, focusing on a set of highly expressed dual-specificity phosphatases (DUSPs). Elevated expression of DUSP6 in patients harboring FLT3 ITD was detected in this analysis. The mechanism and functional role of FLT3 ITD-mediated upregulation of DUSP6 was then explored using pharmacological inhibitors of FLT3 ITD signal transduction and si/shRNA technology in human and murine cell lines. High DUSP6 expression was causally associated with the presence of FLT3 ITD and dependent on FLT3 ITD kinase activity and ERK signaling. DUSP6 depletion moderately increased ERK1/2 activity but attenuated FLT3 ITD-dependent cell proliferation of 32D cells. In conclusion, DUSP6 may play a contributing role to FLT3 ITD-mediated cell transformation.
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| 4. |
- Burillo, S. G., et al.
(författare)
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Molecular line emission in NGC 1068 imaged with ALMA : I. An AGN-driven outflow in the dense molecular gas
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 567, s. 125-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We investigate the fueling and the feedback of star formation and nuclear activity in NGC 1068, a nearby (D = 14 Mpc) Seyfert 2 barred galaxy, by analyzing the distribution and kinematics of the molecular gas in the disk. We aim to understand if and how gas accretion can self-regulate.Methods. We have used the Atacama Large Millimeter Array (ALMA) to map the emission of a set of dense molecular gas (n(H2) ' 1056 cm3) tracers (CO(3-2), CO(6-5), HCN(4-3), HCO+(4-3), and CS(7-6)) and their underlying continuum emission in the central r ∼ 2 kpc of NGC 1068 with spatial resolutions ∼0:3000:500 (∼20-35 pc for the assumed distance of D = 14 Mpc). Results. The sensitivity and spatial resolution of ALMA give an unprecedented detailed view of the distribution and kinematics of the dense molecular gas (n(H2) ≈ 1056cm3) in NGC 1068. Molecular line and dust continuum emissions are detected from a r ∼ 200 pc off-centered circumnuclear disk (CND), from the 2.6 kpc-diameter bar region, and from the r ∼ 1:3 kpc starburst (SB) ring. Most of the emission in HCO+, HCN, and CS stems from the CND. Molecular line ratios show dramatic order-of-magnitude changes inside the CND that are correlated with the UV/X-ray illumination by the active galactic nucleus (AGN), betraying ongoing feedback. We used the dust continuum fluxes measured by ALMA together with NIR/MIR data to constrain the properties of the putative torus using CLUMPY models and found a torus radius of 20+6 10 pc. The Fourier decomposition of the gas velocity field indicates that rotation is perturbed by an inward radial flow in the SB ring and the bar region. However, the gas kinematics from r ∼ 50 pc out to r ∼ 400 pc reveal a massive (Mmol ∼ 2:7+0:9 1:2 × 107 M) outflow in all molecular tracers. The tight correlation between the ionized gas outflow, the radio jet, and the occurrence of outward motions in the disk suggests that the outflow is AGN driven. Conclusions. The molecular outflow is likely launched when the ionization cone of the narrow line region sweeps the nuclear disk. The outflow rate estimated in the CND, dM=dt ∼ 63+21 37 M yr1, is an order of magnitude higher than the star formation rate at these radii, confirming that the outflow is AGN driven. The power of the AGN is able to account for the estimated momentum and kinetic luminosity of the outflow. The CND mass load rate of the CND outflow implies a very short gas depletion timescale of ≤1 Myr. The CND gas reservoir is likely replenished on longer timescales by efficient gas inflow from the outer disk. © ESO 2014.
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| 5. |
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| 6. |
- Costagliola, Francesco, 1981, et al.
(författare)
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High-resolution mm and cm study of the obscured LIRG NGC 4418 A compact obscured nucleus fed by in-falling gas?
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 556
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Tidskriftsartikel (refereegranskat)abstract
- Context. Understanding the nature of the power-source in luminous infrared galaxies (LIRG) is difficult due to their extreme obscuration. Observations at radio and mm wavelengths can penetrate large columns of dust and gas and provide unique insights into the properties of the compact obscured nuclei of LIRGs. Aims. The aim of this study is to constrain the dynamics, structure, and feeding of the compact nucleus of NGC 4418, and to reveal the nature of the main hidden power-source: starburst or active galactic nucleus (AGN). Methods. We obtained high spatial resolution observations of NGC 4418 at 1.4 and 5 GHz with MERLIN, and at 230 and 270 GHz with the SMA in very extended configuration. We used the continuum morphology and flux density to estimate the size of the emitting region, the star formation rate, and the dust temperature. Emission lines were used to study kinematics through position-velocity diagrams. Molecular emission was studied with population diagrams and by fitting a local thermal equilibrium (LTE) synthetic spectrum. Results. We detect bright 1-mm-line emission from CO, HC3N, HNC, and (CS)-S-34 and 1.4 GHz absorption from HI. The CO 2-1 emission and HI absorption can be fit by two velocity components at 2090 and 2180 km s(-1). We detect vibrationally excited HC3N and HNC, with T-vib similar to 300 K. Molecular excitation is consistent with a layered temperature structure, with three main components at 80, 160, and 300 K. For the hot component we estimate a source size of less than 5 pc. The nuclear molecular gas surface density of 10(4) M-circle dot pc(-2) is extremely high and similar to that found in the ultra-luminous infrared galaxy (ULIRG) Arp220. Conclusions. Our observations confirm the presence of a molecular and atomic in-flow, previously suggested by Herschel observations, which is feeding the activity in the center of NGC 4418. Molecular excitation confirms the presence of a very compact, hot dusty core. If a starburst is responsible for the observed IR flux, this has to be at least as extreme as the one in the ULIRG Arp 220, with an age of 3-10 Myr and a star formation rate > 10 M-circle dot yr(-1). If an AGN is present, it must be extremely Compton-thick.
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| 7. |
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| 8. |
- Costagliola, Francesco, 1981, et al.
(författare)
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Molecules as tracers of galaxy evolution: an EMIR survey I. Presentation of the data and first results
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 528
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We investigate the molecular gas properties of a sample of 23 galaxies in order to find and test chemical signatures of galaxy evolution and to compare them to IR evolutionary tracers. Methods. Observation at 3 mm wavelengths were obtained with the EMIR broadband receiver, mounted on the IRAM 30 m telescope on Pico Veleta, Spain. We compare the emission of the main molecular species with existing models of chemical evolution by means of line intensity ratios diagrams and principal component analysis. Results. We detect molecular emission in 19 galaxies in two 8 GHz-wide bands centred at 88 and 112 GHz. The main detected molecules are CO, (CO)-C-13, HCN, HNC, HCO+, CN, and C2H. We also detect HC3N J = 10-9 in the galaxies IRAS 17208, IC 860, NGC 4418, NGC 7771, and NGC 1068. The only HC3N detections are in objects with HCO+/HCN 0.8). The brightest HC3N emission is found in IC 860, where we also detect the molecule in its vibrationally excited state. We find low HNC/HCN line ratios (
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| 9. |
- Eimermann, Marco, 1979-
(författare)
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There and back again? : Dutch lifestyle migrants moving to rural Sweden in the early 21st century.
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis has a twofold aim. First, it studies motivations and decision processes of Dutch families moving to rural Sweden, with a focus on Hällefors municipality in the Bergslagen area. Second, it explores how this migration flow can be conceptualised within migration theory. The results of the study are presented in four papers.The migrants’ characteristics are explored using variables from the Bergslagen Database. This is complemented with data from interviews with municipality officials, project leaders and Dutch families in rural Sweden.The theoretical framework consists of literature on counterurbanisation, the creative class thesis and lifestyle migration. The creative class thesis has inspired many rural place marketing projects and efforts to attract the ‘right type’ of people to stimulate rural development. Based on the interview study, I argue that lifestyle migration research offers most apt insights into the act of migration within the wider life trajectories of these Dutch families.The thesis offers new empirical data that suggest amendments to be made to the academic definition of lifestyle migration. Additional contributions consider the novel geographic direction of the migration flow (northwards), the destination (a deprived area) and the structure framing the decision process; a local authority and its deliberate attempts to attract new residents from abroad. The findings suggest transcending four binaries. First, in the context of an integrating EU, the thesis adds international dimensions to the initial story of internal counterurbanisation. Second, these flexibly mobile families transcend and combine issues of urbanity and rurality through access- facilitating technology and cheap means of long distance transport. Third, this study reiterates the importance of production as a complement to consumption in lifestyle migration research. Finally, the thesis adds dynamic issues of transience to the static permanent-temporary binary of migration.
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| 10. |
- Haider, Susanne, et al.
(författare)
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Raman microspectroscopy reveals long-term extracellular activity of Chlamydiae
- 2010
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Ingår i: Molecular Microbiology. - : Blackwell Publishing. - 0950-382X .- 1365-2958. ; 77:3, s. 687-700
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Tidskriftsartikel (refereegranskat)abstract
- The phylum Chlamydiae consists exclusively of obligate intracellular bacteria. Some of them are formidable pathogens of humans, while others occur as symbionts of amoebae. These genetically intractable bacteria possess a developmental cycle consisting of replicative reticulate bodies and infectious elementary bodies, which are believed to be physiologically inactive. Confocal Raman microspectroscopy was applied to differentiate between reticulate bodies and elementary bodies of Protochlamydia amoebophila and to demonstrate in situ the labelling of this amoeba symbiont after addition of isotope-labelled phenylalanine. Unexpectedly, uptake of this amino acid was also observed for both developmental stages for up to 3 weeks, if incubated extracellularly with labelled phenylalanine, and P. amoebophila remained infective during this period. Furthermore, P. amoebophila energizes its membrane and performs protein synthesis outside of its host. Importantly, amino acid uptake and protein synthesis after extended extracellular incubation could also be demonstrated for the human pathogen Chlamydia trachomatis, which synthesizes stress-related proteins under these conditions as shown by 2-D gel electrophoresis and MALDI-TOF/TOF mass spectrometry. These findings change our perception of chlamydial biology and reveal that host-free analyses possess a previously not recognized potential for direct experimental access to these elusive microorganisms.
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