| 1. |
- Al-Yahri, Omer, et al.
(författare)
-
First ever case report of co-occurrence of hobnail variant of papillary thyroid carcinoma and intrathyroid parathyroid adenoma in the same thyroid lobe
- 2020
-
Ingår i: International Journal of Surgery Case Reports. - : Elsevier. - 2210-2612. ; 70, s. 40-52
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: The hobnail variant of papillary thyroid cancer (PTC) is rare. Intrathyroid parathyroid adenoma (ITPA) is also rare. Co-ocurrence of PTC and ITPA in the same thyroid lobe is extremely rare. Likewise, primary hyperparathyroidism with such non-medullary thyroid carcinoma is rare. The specific molecular profile of hobnail PTC (HPTC) is different from the classic, poorly differentiated and anaplastic variants and may contribute to its aggressive behavior. HPTC's genetic profile remains unclear. Presentation of case: A 61-year-old woman presented to our endocrine clinic with generalized aches, bone pain, polyuria, and right neck swelling of a few months’ duration. Laboratory findings revealed hypercalcemia and hyperparathyroidism. Ultrasound of the neck showed 4.6 cm complex nodule within the right thyroid lobe. Sestamibi scan suggested parathyroid adenoma in the right thyroid lobe. Fine-needle aspiration (FNA) revealed atypical follicular lesion of undetermined significance. She underwent right lobectomy, which normalized the intraoperative intact parathyroid hormone levels. Final pathology with immunohistochemical stains demonstrated HPTC and IPTA (2 cm each). Next-generation sequencing investigated the mutation spectrum of HPTC and detected BRAFV600E mutation. Conclusions: A parathyroid adenoma should not exclude the diagnosis of thyroid carcinoma. Thyroid evaluation is needed for patients with primary hyperparathyroidism to prevent missing concurrent thyroid cancers. Cytomorphologic features to distinguish thyroid from parathyroid cells on FNA cytology must be considered. Immunohistochemical stains are important. BRAFV600E is the most common mutation in HPTC. This is possibly the first reported case of HPTC and ITPA co-occurring within the same thyroid lobe. Studies that define other molecular abnormalities may be useful as therapeutic targets. © 2020 The Author(s)
|
|
| 2. |
|
|
| 3. |
- Sodemann, B, et al.
(författare)
-
Periarticular heterotopic ossification after total hip arthroplasty for primary coxarthrosis.
- 1988
-
Ingår i: Clinical Orthopaedics and Related Research. - 0009-921X .- 1528-1132. ; :237, s. 150-7
-
Tidskriftsartikel (refereegranskat)abstract
- Periarticular heterotopic ossification (PHO) is a common roentgenographic finding, occurring in more than two-thirds of patients after total hip arthroplasty (THA) for coxarthrosis. In the present study, 56 patients treated with bilateral THA were analyzed to determine the correlation between heterotopic ossification on the two sides. A strong correlation was found between the grade of PHO on the two sides: patients who developed severe PHO after the first THA invariably developed considerable PHO after surgery on the other side. The incidence and grade of PHO were higher in men than in women.
|
|
| 4. |
|
|
| 5. |
- Sadeghisorkhani, Hamzeh, et al.
(författare)
-
Shear wave structure of southern Sweden from precise phase-velocity measurements of ambient-noise data
- 2021
-
Ingår i: Geophysical Journal International. - : Oxford University Press. - 0956-540X .- 1365-246X. ; 225:1, s. 494-511
-
Tidskriftsartikel (refereegranskat)abstract
- Rayleigh-wave phase-velocity tomography of southern Sweden is presented using ambient seismic noise at 36 stations (630 station pairs) of the Swedish National Seismic Network. We analyse 1 yr (2012) of continuous recordings to get the first crustal image based on the ambient-noise method in the area. Time-domain cross-correlations of the vertical component between the stations arc computed. Phase-velocity dispersion curves arc measured in the frequency domain by matching zero crossings of the real spectra of cross-correlations to the zero crossings of the zeroth-order Bessel function of the first kind. We analyse the effect of uneven source distributions on the phase-velocity dispersion curves and correct for the estimated velocity bias before tomography. To estimate the azimuthal source distribution to determine the bias, we perform inversions of amplitudes of cross-correlation envelopes in a number of period ranges. Then, we invert the measured and bias-corrected dispersion curves for phase-velocity maps at periods between 3 and 30 s. In addition, we investigate the effects of phase-velocity bias corrections on the inverted tomographic maps. The difference between bias-corrected and -uncorrected phase-velocity maps is small (<1.2 per cent), but the correction significantly reduces the residual data variance at long periods where the bias is biggest. To obtain a shear velocity model, we invert for a 1-D velocity profile at each geographical node. The results show some correlation with surface geology, regional seismicity and gravity anomalies in the upper crust. Below the upper crust, the results agree well with results from other seismological methods.
|
|
| 6. |
- Vigiak, Olga, et al.
(författare)
-
A semi-empirical model to assess uncertainty of spatial patterns of erosion
- 2006
-
Ingår i: Catena (Cremlingen. Print). - : Elsevier. - 0341-8162 .- 1872-6887. ; 66:3, s. 198-210
-
Tidskriftsartikel (refereegranskat)abstract
- Distributed erosion models are potentially good tools for locating soil sediment sources and guiding efficient Soil and Water Conservation (SWC) planning, but the uncertainty of model predictions may be high. In this study, the distribution of erosion within a catchment was predicted with a semi-empirical erosion model that combined a semi-distributed hydrological model with the Morgan, Morgan and Finney (MMF) empirical erosion model. The model was tested in a small catchment of the West Usambara Mountains (Kwalei catchment, Tanzania). Soil detachability rates measured in splash cups (0.48-1.16gJ(-1)) were close to model simulations (0.30-0.35gJ(-1)). Net erosion rates measured in Gerlach troughs (0.01-1.05kgm(-2) per event) were used to calibrate the sediment transport capacity of overland flow. Uncertainties of model simulations due to parameterisation of overland flow sediment transport capacity were assessed with the Generalized Likelihood Uncertainty Estimation (GLUE) methodology. The quality of the spatial predictions was assessed by comparing the simulated erosion pattern with the field-observed erosion pattern, measuring the agreement with the weighted Kappa coefficient of the contingency table. Behavioural parameter sets (weighted Kappa > 0.50) were those with short reinfiltration length (< 1.5m) and ratio of overland flow power a to local topography power close to 0.5. In the dynamic Hortonian hydrologic regime and the dissected terrain of Kwalei catchment, topography controlled the distribution of erosion more than overland flow. Simulated erosion rates varied from -4 to +2kgm(-2) per season. The model simulated correctly around 75% of erosion pattern. The uncertainty of model predictions due to sediment transport capacity was high; around 10% of the fields were attributed to either slight or severe erosion. The difficult characterisation of catchment-scale effective sediment transport capacity parameters poses a major limit to distributed erosion modelling predicting capabilities. Crown Copyright (c) 2006 Published by Elsevier B.V. All rights reserved.
|
|
