| 1. |
- Boldis, Beata Vivien, 1993-, et al.
(author)
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Comorbidities in women with polycystic ovary syndrome : a sibling study
- 2024
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In: BMC Women's Health. - 1472-6874. ; 24:1, s. 221-221
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Journal article (peer-reviewed)abstract
- BACKGROUND: Polycystic ovary syndrome (PCOS) has previously been associated with several comorbidities that may have shared genetic, epigenetic, developmental or environmental origins. PCOS may be influenced by prenatal androgen excess, poor intrauterine or childhood environmental factors, childhood obesity and learned health risk behaviors. We analyzed the association between PCOS and several relevant comorbidities while adjusting for early-life biological and socioeconomic conditions, also investigating the extent to which the association is affected by familial risk factors. METHODS: This total-population register-based cohort study included 333,999 full sisters, born between 1962 and 1980. PCOS and comorbidity diagnoses were measured at age 17-45 years through national hospital register data from 1997 to 2011, and complemented with information on the study subjects´ early-life and social characteristics. In the main analysis, sister fixed effects (FE) models were used to control for all time-invariant factors that are shared among sisters, thereby testing whether the association between PCOS and examined comorbidities is influenced by unobserved familial environmental, social or genetic factors. RESULTS: Three thousand five hundred seventy women in the Sister sample were diagnosed with PCOS, of whom 14% had obesity, 8% had depression, 7% had anxiety and 4% experienced sleeping, sexual and eating disorders (SSE). Having PCOS increased the odds of obesity nearly 6-fold (adjusted OR (aOR): 5.9 [95% CI:5.4-6.5]). This association was attenuated in models accounting for unobserved characteristics shared between full sisters, but remained considerable in size (Sister FE: aOR: 4.5 [95% CI: 3.6-5.6]). For depression (Sister FE: aOR: 1.4 [95% CI: 1.2-1.8]) and anxiety (Sister FE: aOR: 1.5 [95% CI: 1.2-1.8), there was a small decrease in the aORs when controlling for factors shared between sisters. Being diagnosed with SSE disorders yielded a 2.4 aOR (95% CI:2.0-2.6) when controlling for a comprehensive set of individual-level confounders, which only decreased slightly when controlling for factors at the family level such as shared genes or parenting style. Accounting for differences between sisters in observed early-life circumstances influenced the estimated associations marginally. CONCLUSION: Having been diagnosed with PCOS is associated with a markedly increased risk of obesity and sleeping, sexual and eating disorders, also after accounting for factors shared between sisters and early-life conditions.
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| 2. |
- Bengtsson, Tommy, et al.
(author)
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The Late Emergence of the Socioeconomic Gradient in Adult Mortality: An Urban Phenomenon?
- 2024
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In: Urban Lives. An Industrial City and Its People During the Twentieth Century. - 9780197761090 - 9780197761113 - 9780197761120 ; , s. 281-306
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Book chapter (peer-reviewed)abstract
- Previous research has shown that class differences in adult mortality in the study area emerged only in the mid-twentieth century. Such findings question a universal association between socioeconomic status and mortality. This chapter examines whether these class differences in adult mortality emerged at the same time in urban as in rural areas. The analysis shows that the social class gradient in mortality was more pronounced in the urban than in the rural area, and hence that it was primarily an urban phenomenon. The urban mortality penalty in the study area lasted considerably longer than has been found for Sweden as a whole, but presumably with changing explanations over time. In the early twentieth century, the higher urban mortality was probably connected to poor living conditions in the city, while in the late twentieth century it was likely more related to differences in lifestyle and possibly work-related stress.
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| 3. |
- Bonander, Carl, et al.
(author)
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A Capture-Recapture-based Ascertainment Probability Weighting Method for Effect Estimation With Under-ascertained Outcomes.
- 2024
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In: Epidemiology (Cambridge, Mass.). - : Lippincott Williams & Wilkins. - 1531-5487 .- 1044-3983. ; 35:3, s. 340-348
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Journal article (peer-reviewed)abstract
- Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates capture-recapture and propensity score weighting. We propose a nonparametric estimator of effects on binary outcomes that combines exposure propensity scores with data from two conditionally independent outcome measurements to simultaneously adjust for confounding and under-ascertainment. Demonstrating its practical application, we apply the method to estimate the relationship between health care work and coronavirus disease 2019 testing in a Swedish region. We find that ascertainment probability weighting greatly influences the estimated association compared to conventional inverse probability weighting, underscoring the importance of accounting for under-ascertainment in studies with limited outcome data coverage. We conclude with practical guidelines for the method's implementation, discussing its strengths, limitations, and suitable scenarios for application.
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| 4. |
- Bååth, Jonas, et al.
(author)
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The art of being governed : The implementation of Covid-19 policy in Swedish on-license alcohol service
- 2024
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In: Food, Culture & Society. - : Informa UK Limited. - 1552-8014 .- 1751-7443. ; 27:1, s. 202-220
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Journal article (peer-reviewed)abstract
- The licensed serving of alcoholic beverages is an important institutional aspect of food culture. In Sweden, the Government’s policies to battle the Covid-19 pandemic meant further restrictions, including a temporary law, to mitigate contagion at licensed restaurants, bars, producers’ tasting events, etc. This paper inquiries into the “art” exercised by managers of such businesses, already used to strict governance, of “being governed” when faced with these new and sudden policies. The study draws on Swedish Covid-19 policy and interviews with managers of licensed premises and a municipal auditor during the three months of the most far-reaching restrictions. By analyzing these materials through anthropological theories of state governance, the paper shows how Covid-19 restrictions were enacted in practice, including their discontents. The study’s findings contribute to further insights into the role of alcohol policy in food culture and opens up for further bridging of food studies, service studies, and alcohol research.
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| 5. |
- Fridman, Jonas, et al.
(author)
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Harmonised statistics and maps of forest biomass and increment in Europe
- 2024
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In: Scientific Data. - 2052-4463. ; 11
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Journal article (peer-reviewed)abstract
- Forest biomass is an essential resource in relation to the green transition and its assessment is key for the sustainable management of forest resources. Here, we present a forest biomass dataset for Europe based on the best available inventory and satellite data, with a higher level of harmonisation and spatial resolution than other existing data. This database provides statistics and maps of the forest area, biomass stock and their share available for wood supply in the year 2020, and statistics on gross and net volume increment in 2010–2020, for 38 European countries. The statistics of most countries are available at a sub-national scale and are derived from National Forest Inventory data, harmonised using common reference definitions and estimation methodology, and updated to a common year using a modelling approach. For those counties without harmonised statistics, data were derived from the State of Europe’s Forest 2020 Report at the national scale. The maps are coherent with the statistics and depict the spatial distribution of the forest variables at 100 m resolution.
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| 6. |
- Gonzalez-Ortiz, Fernando, 1990, et al.
(author)
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Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease.
- 2024
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In: Nature communications. - 2041-1723. ; 15:1
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Journal article (peer-reviewed)abstract
- Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer's disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ pathophysiology but an AD-type neurodegeneration biomarker has been lacking. In this multicenter study (n=1076), we show that brain-derived tau (BD-tau) in blood increases according to concomitant Aβ ("A") and neurodegeneration ("N") abnormalities (determined using cerebrospinal fluid biomarkers); We used blood-based A/N biomarkers to profile the participants in this study; individuals with blood-based p-tau+/BD-tau+ profiles had the fastest cognitive decline and atrophy rates, irrespective of the baseline cognitive status. Furthermore, BD-tau showed no or much weaker correlations with age, renal function, other comorbidities/risk factors and self-identified race/ethnicity, compared with other blood biomarkers. Here we show that blood-based BD-tau is a biomarker for identifying Aβ-positive individuals at risk of short-term cognitive decline and atrophy, with implications for clinical trials and implementation of anti-Aβ therapies.
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| 7. |
- Granestrand, Jonas, 1988-, et al.
(author)
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Assessment of the impact of trace elements in FAME biodiesel on diesel oxidation catalyst activity after full lifetime of operation in a heavy-duty truck
- 2024
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In: Applied Catalysis B. - Amsterdam : Elsevier. - 0926-3373 .- 1873-3883.
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Journal article (peer-reviewed)abstract
- FAME biodiesel contains some trace amounts of Na, K, P, Ca and Mg. A diesel oxidation catalyst that had been used for an entire regulatory lifetime in a heavy-duty truck was studied, to investigate whether the presence of such trace elements poisons the catalyst. The vehicle-aged catalyst contained high loadings of S, P and Na, as well as a visible layer of soot. Activity in the NO oxidation reaction was severely decreased compared to a fresh catalyst of the same type, while the CO and C3H6 oxidation reactions were less affected. Activity testing after subsequent selective trace element removal procedures was used to decouple the effect of different poisons. Sintering was observed to be the main cause of catalyst deactivation. Of the trace elements present on the catalyst, P had the largest effect on catalyst activity, while the other trace elements had little effect.
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| 8. |
- Hedström, Jonas, et al.
(author)
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Cholecystectomy and ERCP in pregnancy : a nationwide register-based study
- 2024
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In: International journal of surgery (London, England). - 1743-9159. ; 110:1, s. 324-331
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Journal article (peer-reviewed)abstract
- OBJECTIVE: The objective was to examine the outcomes of cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) during pregnancy and compare these outcomes with those in nonpregnant women of fertile age. SUMMARY BACKGROUND DATA: Although both laparoscopic cholecystectomy and ERCP are considered safe and feasible in pregnant patients, there is still concern and uncertainty regarding gallstone intervention during pregnancy. This study aimed to investigate outcomes in pregnant patients compared to outcomes in nonpregnant patients. METHODS: Data on all female patients aged 18-45 years were retrieved from the Swedish Registry for Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography. The patients were divided into groups according to intervention: cholecystectomy, ERCP, or a combination thereof. Differences between pregnant and nonpregnant patients were analyzed. RESULTS: A total of 21 328 patients were included, with 291 cholecystectomy and 63 ERCP procedures performed in pregnant patients. At the 30-day follow-up, more complications after cholecystectomy were registered for pregnant patients. However, pregnancy was not a significant risk factor for adverse events when adjusting for previous complicated gallstone disease, intraoperative complications, emergency surgery, and common bile duct stones. There were no differences in outcomes when comparing cholecystectomy among the different trimesters. ERCP had no significant effect on outcomes at the 30-day follow-up. CONCLUSION: Cholecystectomy, ERCP, and combinations thereof are safe during pregnancy.
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| 9. |
- Huang, Junchi, et al.
(author)
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MYB alternative promoter activity is increased in adenoid cystic carcinoma metastases and is associated with a specific gene expression signature
- 2024
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In: ORAL ONCOLOGY. - 1368-8375 .- 1879-0593. ; 151
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Journal article (peer-reviewed)abstract
- Objective: Adenoid cystic carcinoma (ACC) is a head and neck cancer with a poor long-term prognosis that shows frequent local recurrences and distant metastases. The tumors are characterized by MYB oncogene activation and are notoriously unresponsive to systemic therapies. The biological underpinnings behind therapy resistance of disseminated ACC are largely unknown. Here, we have studied the molecular and clinical significance of MYB alternative promoter (TSS2) usage in ACC metastases. Materials and methods: MYB TSS2 activity was investigated in primary tumors and metastases from 26 ACC patients using RNA-sequencing and quantitative real-time PCR analysis. Differences in global gene expression between MYB TSS2 high and low cases were studied, and pathway analyses were performed. Results: MYB TSS2 activity was significantly higher in ACC metastases than in primary tumors (median activity 15.1 vs 3.0, P = 0.0003). MYB TSS2 high ACC metastases showed a specific gene expression signature, including increased expression of multi-drug resistance genes and canonical MYB target genes, and suppression of the p53 and NOTCH pathways. Conclusions: Collectively, our findings indicate that elevated MYB TSS2 activity is associated with metastases, potential drug resistance, and augmented MYB-driven gene expression in ACC. Our study advocates the need for new therapies that specifically target MYB and drug resistance mechanisms in disseminated ACC.
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| 10. |
- Kataria, Bharti, 1955-, et al.
(author)
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Image quality in CT thorax: effect of altering reconstruction algorithm and tube load : Image quality in CT thorax
- 2024
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In: Radiation Protection Dosimetry. - : Oxford University Press. - 0144-8420 .- 1742-3406. ; 200:5, s. 504-514
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Journal article (peer-reviewed)abstract
- Non-linear properties of iterative reconstruction (IR) algorithms can alter image texture. We evaluated the effect of a model-basedIR algorithm (advanced modelled iterative reconstruction; ADMIRE) and dose on computed tomography thorax image quality.Dual-source scanner data were acquired at 20, 45 and 65 reference mAs in 20 patients. Images reconstructed with filteredback projection (FBP) and ADMIRE Strengths 3–5 were assessed independently by six radiologists and analysed using an ordinallogistic regression model. For all image criteria studied, the effects of tube load 20 mAs and all ADMIRE strengths were significant(p < 0.001) when compared to reference categories 65 mAs and FBP. Increase in tube load from 45 to 65 mAs showed imagequality improvement in three of six criteria. Replacing FBP with ADMIRE significantly improves perceived image quality for allcriteria studied, potentially permitting a dose reduction of almost 70% without loss in image quality
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