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| 2. |
- Fröbert, Ole, et al.
(author)
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Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction
- 2013
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In: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 369:17, s. 1587-1597
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Journal article (peer-reviewed)abstract
- BackgroundThe clinical effect of routine intracoronary thrombus aspiration before primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) is uncertain. We aimed to evaluate whether thrombus aspiration reduces mortality. MethodsWe conducted a multicenter, prospective, randomized, controlled, open-label clinical trial, with enrollment of patients from the national comprehensive Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and end points evaluated through national registries. A total of 7244 patients with STEMI undergoing PCI were randomly assigned to manual thrombus aspiration followed by PCI or to PCI only. The primary end point was all-cause mortality at 30 days. ResultsNo patients were lost to follow-up. Death from any cause occurred in 2.8% of the patients in the thrombus-aspiration group (103 of 3621), as compared with 3.0% in the PCI-only group (110 of 3623) (hazard ratio, 0.94; 95% confidence interval [CI], 0.72 to 1.22; P=0.63). The rates of hospitalization for recurrent myocardial infarction at 30 days were 0.5% and 0.9% in the two groups, respectively (hazard ratio, 0.61; 95% CI, 0.34 to 1.07; P=0.09), and the rates of stent thrombosis were 0.2% and 0.5%, respectively (hazard ratio, 0.47; 95% CI, 0.20 to 1.02; P=0.06). There were no significant differences between the groups with respect to the rate of stroke or neurologic complications at the time of discharge (P=0.87). The results were consistent across all major prespecified subgroups, including subgroups defined according to thrombus burden and coronary flow before PCI. ConclusionsRoutine thrombus aspiration before PCI as compared with PCI alone did not reduce 30-day mortality among patients with STEMI. (Funded by the Swedish Research Council and others; ClinicalTrials.gov number, NCT01093404.)
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| 3. |
- Storry, Jill, et al.
(author)
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Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype
- 2013
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 537-U109
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Journal article (peer-reviewed)abstract
- The Vel antigen is present on red blood cells (RBCs) from all humans except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in blood recipients. We combined SNP profiling and transcriptional network modeling to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on chromosome 1p36. This gene encodes a previously undiscovered, evolutionarily conserved transmembrane protein expressed on RBCs. Notably, 35 of 35 Vel-negative individuals were homozygous for a frameshift deletion of 17 bp in exon 3. Functional studies using antibodies raised against SMIM1 peptides confirmed a null phenotype in RBC membranes, and SMIM1 overexpression induced Vel expression. Genotype screening estimated that similar to 1 of 17 Swedish blood donors is a heterozygous deletion carrier and similar to 1 of 1,200 is a homozygous deletion knockout and enabled identification of Vel-negative donors. Our results establish SMIM1 as a new erythroid gene and Vel as a new blood group system.
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| 4. |
- Abay, Simon, 1980, et al.
(author)
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Quantized Conductance and Its Correlation to the Supercurrent in a Nanowire Connected to Superconductors
- 2013
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In: Nano Letters. - : American Chemical Society (ACS). - 1530-6992 .- 1530-6984. ; 13:8, s. 3614-3617
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Journal article (peer-reviewed)abstract
- We report conductance and supercurrent of InAs nano wires coupled to Al-superconducting electrodes with short channel lengths and good Ohmic contacts. The nanowires are suspended 15 nm above a local gate electrode. The charge density in the nanowires can be controlled by a small change in the gate voltage. For large negative gate voltages, the number of conducting channels is reduced gradually, and we observe a stepwise decrease of both conductance and critical current before the conductance vanishes completely.
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| 5. |
- Andéhn, Mikael, 1982-
(author)
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Place-of-Origin Effects on Brand Equity : Explicating the evaluative pertinence of product categories and association strength
- 2013
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Doctoral thesis (other academic/artistic)abstract
- The country-of-origin effect - the alteration of judgment derived from an association to a place, is a much studied phenomenon with great potential implications for brand management and international marketing. However, in light of criticism towards the lack of conceptual development the extant literature, the relevance of the effect has been brought into question.Through an exploration of the psychology of the association between brands and places, the country-of-origin effect is reimagined focusing on the role of association strength as well as how the interplay between place and product categories can shape consumer attitudes.The results of a series of psychometric tests suggest that association strength and the interplay between place and product category constitute antecedent conditions that are crucial for determining if a country-of-origin effect will occur. These findings, and their implications for future research as well as for practice, suggest that a reevaluation of the country-of-origin effect with a widening of the scope to encompass the commercial relevance of place writ large is warranted.
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| 6. |
- Ardö, Håkan, et al.
(author)
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Reduced Search Space for Rapid Bicycle Detection
- 2013
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In: [Host publication title missing]. - : SciTePress - Science and and Technology Publications.
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Conference paper (peer-reviewed)abstract
- This paper describes a solution to the application of rapid detection of bicycles in low resolution video. In particular, the application addressed is from video recorded in a live environment. The future aim from the results in this paper is to investigate a full year of video data. Hence, processing speed is of great concern. The proposed solution involves the use of an object detector and a search space reduction method based on prior knowledge regarding the application at hand. The method using prior knowledge utilizes random sample consensus, and additional statistical analysis on detection outputs, in order to define a reduced search space. It is experimentally shown that, in the application addressed, it is possible to reduce the full search space by 62% with the proposed methodology. This approach, which employs a full detector in combination with the design of a simple and fast model that can capture prior knowledge for a specific application, leads to a reduced search space and thereby a significantly improved processing speed.
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| 7. |
- Arja, Katriann, et al.
(author)
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Enhanced Fluorescent Assignment of Protein Aggregates by an Oligothiophene-Porphyrin-Based Amyloid Ligand
- 2013
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In: Macromolecular rapid communications. - : Wiley-VCH Verlag. - 1022-1336 .- 1521-3927. ; 34:9, s. 723-730
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Journal article (peer-reviewed)abstract
- Fluorescent probes identifying protein aggregates are of great interest, as deposition of aggregated proteins is associated with many devastating diseases. Here, we report that a fluorescent amyloid ligand composed of two distinct molecular moieties, an amyloidophilic pentameric oligothiophene and a porphyrin, can be utilized for spectral and lifetime imaging assessment of recombinant A 1-42 amyloid fibrils and A deposits in brain tissue sections from a transgenic mouse model with Alzheimers disease pathology. The enhanced spectral range and distinct lifetime diversity of this novel oligothiopheneporphyrin-based ligand allow a more precise assessment of heterogeneous amyloid morphology compared with the corresponding oligothiophene dye.
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| 8. |
- Bartunek, Josef Strom, et al.
(author)
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Adaptive Fingerprint Image Enhancement with Emphasis on Preprocessing of Data
- 2013
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In: IEEE Transactions on Image Processing. - : IEEE. - 1941-0042 .- 1057-7149. ; 22:2, s. 644-656
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Journal article (peer-reviewed)abstract
- This article proposes several improvements to an adaptive fingerprint enhancement method that is based on contextual filtering. The term adaptive implies that parameters of the method are automatically adjusted based on the input fingerprint image. Five processing blocks comprise the adaptive fingerprint enhancement method, where four of these blocks are updated in our proposed system. Hence, the proposed overall system is novel. The four updated processing blocks are; preprocessing, global analysis, local analysis and matched filtering. In the pre-processing and local analysis blocks, a nonlinear dynamic range adjustment method is used. In the global analysis and matched filtering blocks, different forms of order statistical filters are applied. These processing blocks yield an improved and new adaptive fingerprint image processing method. The performance of the updated processing blocks is presented in the evaluation part of this paper. The algorithm is evaluated towards the NIST developed NBIS software for fingerprint recognition on FVC databases.
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| 9. |
- Betz, Mattias J., et al.
(author)
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Presence of Brown Adipocytes in Retroperitoneal Fat From Patients With Benign Adrenal Tumors: Relationship With Outdoor Temperature
- 2013
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In: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 98:10, s. 4097-4104
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Journal article (peer-reviewed)abstract
- Context: Brown adipose tissue (BAT) is a metabolically highly active organ with increased thermogenic activity in rodents exposed to cold temperature. Recently its presence in the cervical adipose tissue of human adults and its association with a favorable metabolic phenotype have been reported. Objective: The objective of the study was to determine the prevalence of retroperitoneal BAT in human adults. Patients: Fifty-seven patients who underwent surgery for benign adrenal tumors were included in this study. Main Outcome Measures: Prevalence of retroperitoneal BAT adjacent to the removed adrenal tumor as determined by uncoupling protein 1 (UCP1) protein and mRNA expression was measured. Results: Using protein and mRNA expression analysis, we detected UCP1 protein in 26 of 57 patients (45.6%) as well as high mRNA expression of genes characteristic for brown adipocytes, independent of the adrenal tumor type. The presence of brown adipocytes within the retroperitoneal fat was associated with a significantly lower outdoor temperature during the month prior to surgery. Importantly, UCP1 expression on both mRNA and protein level was inversely correlated to outdoor temperature, whereas body mass index, sex, age, and diabetes status were not. Conclusions: These findings suggest that human retroperitoneal adipose tissue can acquire a BAT phenotype, thereby adapting to environmental challenges. These adaptive processes might provide a valuable therapeutic target in the treatment of obesity and insulin resistance.
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| 10. |
- Borysiuk, Maciek, et al.
(author)
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Hydrogen analysis and profiling with a position sensitive detector
- 2013
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In: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. - : Elsevier BV. - 0168-583X. ; 306, s. 49-53
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Journal article (peer-reviewed)abstract
- The double sided silicon strip detector (DSSSD) is a segmented silicon detector commonly used in the fields of high energy physics and nuclear physics. This type of detector is used for analysis of reactions produced by charged particles. This makes it well suited for a number of analytical methods commonly used in ion beam analysis (IBA), such as Rutherford Backscattering (RBS) and elastic recoil detection (ERDA). One such detector was installed and tested at Lund Ion Beam Analysis Facility (LIBAF) recently. This is a modification to the existing setup used to measure hydrogen concentrations and depth profiles. When completed it will be used primarily for geological applications. Exact knowledge of the hydrogen content is important in a number of fields, but high enough accuracy can be difficult to achieve with most methods. In IBA normally some variant of ERDA, such as the proton-proton (p-p) coincidence method is used. We describe how the p-p coincidence technique was optimized to get the most out of our experimental setup. Previously this type of spectroscopy has been performed with two detector channels. In the present setup we expand that number from 2 to 96 channels, 64 on the front and 32 on the back of the detector. The intersecting strips give 2048 distinct detector elements or 1024 possible coincidences as dictated by the reaction kinematics. This increase in complexity requires a more detailed data analysis but it rewards us with higher sensitivity and a better background suppression. (C) 2013 Elsevier B.V. All rights reserved.
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