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Sökning: (WFRF:(Ohlsson Anders)) srt2:(2010-2019) > (2017)

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  • Steiner, Ann, et al. (författare)
  • Introduktion
  • 2017
  • Ingår i: Litterära värdepraktiker : aktörer, rum, platser - aktörer, rum, platser. - 9789170612541 ; , s. 9-26
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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  • Gummeson, Anna, et al. (författare)
  • Automatic Gleason grading of H&E stained microscopic prostate images using deep convolutional neural networks
  • 2017
  • Ingår i: Medical Imaging 2017: Digital Pathology. - : SPIE. - 9781510607255 ; 10140
  • Konferensbidrag (refereegranskat)abstract
    • Prostate cancer is the most diagnosed cancer in men. The diagnosis is confirmed by pathologists based on ocular inspection of prostate biopsies in order to classify them according to Gleason score. The main goal of this paper is to automate the classification using convolutional neural networks (CNNs). The introduction of CNNs has broadened the field of pattern recognition. It replaces the classical way of designing and extracting hand-made features used for classification with the substantially different strategy of letting the computer itself decide which features are of importance. For automated prostate cancer classification into the classes: Benign, Gleason grade 3, 4 and 5 we propose a CNN with small convolutional filters that has been trained from scratch using stochastic gradient descent with momentum. The input consists of microscopic images of haematoxylin and eosin stained tissue, the output is a coarse segmentation into regions of the four different classes. The dataset used consists of 213 images, each considered to be of one class only. Using four-fold cross-validation we obtained an error rate of 7.3%, which is significantly better than previous state of the art using the same dataset. Although the dataset was rather small, good results were obtained. From this we conclude that CNN is a promising method for this problem. Future work includes obtaining a larger dataset, which potentially could diminish the error margin.
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  • Manhag, Andreas, et al. (författare)
  • Theodor Wåhlins restaurering av Gråbrödraklostret
  • 2017
  • Ingår i: Ystadiana 2017 : Grabröthrae kloster: Klostret i Ystad 750 år - Grabröthrae kloster: Klostret i Ystad 750 år. - 9789197537094 ; , s. 142-163
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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  • Bentmar Holgersson, Magdalena, et al. (författare)
  • Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele
  • 2017
  • Ingår i: Cancer Causes & Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 28:3, s. 227-233
  • Tidskriftsartikel (refereegranskat)abstract
    • In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. The aim of this study was to replicate this finding in other cohorts, with registry-based cancer diagnosis. Using data from two population-based cohorts; the Malmo Diet and Cancer Study (MDCS, n = 12,121) and the Swedish Osteoporotic fractures in men study (MrOS, n = 1,120), 628 men with PCa and 1,374 controls were identified and genotyped. PCa data were collected from the Swedish national cancer registry. PCa odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for carriers of the particular AR haplotype, tagged by the rs6624304 T-allele. The 15% of men who were carriers of the AR haplotype H2 had approximately one-third lower risk for PCa diagnosis compared to those with the most common H1 variant (OR 0.65; 95% CI 0.45-0.94; p = 0.021). The same trend, although not statistically significant (OR 0.75; 95% CI 0.47-1.24; p = 0.275), was observed in MrOS Sweden. When both cohorts were merged, an even more significant result was observed (OR 0.68; 95% CI 0.51-0.90; p = 0.008). Swedish men with the variant AR haplotype H2, tagged by rs6624304, have significantly lower risk of PCa compared to those with the more common variant.
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