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| 2. |
- Avent, Neil D., et al.
(author)
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The Bloodgen Project of the European Union, 2003-2009
- 2009
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In: Transfusion Medicine and Hemotherapy. - : S. Karger AG. - 1660-3818 .- 1660-3796. ; 36:3, s. 162-167
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Research review (peer-reviewed)abstract
- The Bloodgen project was funded by the European Commission between 2003 and 2006, and involved academic blood centres, universities, and Progenika Biopharma S. A., a commercial supplier of genotyping platforms that incorporate glass arrays. The project has led to the development of a commercially available product, BLOODchip, that can be used to comprehensively genotype an individual for all clinically significant blood groups. The intention of making this system available is that blood services and perhaps even hospital blood banks would be able to obtain extended information concerning the blood group of routine blood donors and vulnerable patient groups. This may be of significant use in the current management of multi-transfused patients who become alloimmunised due to incomplete matching of blood groups. In the future it can be envisaged that better matching of donor-patient blood could be achieved by comprehensive genotyping of every blood donor, especially regular ones. This situation could even be extended to genotyping every individual at birth, which may prove to have significant long-term health economic benefits as it may be coupled with detection of inborn errors of metabolism.
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| 5. |
- King, Andrew, et al.
(author)
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A new type of long gamma-ray burst
- 2007
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In: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 1365-2966 .- 1745-3925 .- 1745-3933. ; 374:1, s. 34-36
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Journal article (peer-reviewed)abstract
- We consider gamma-ray bursts (GRBs) produced by the merger of a massive white dwarf with a neutron star. We show that these are likely to produce long-duration GRBs, in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation, and occur close to the host galaxy. However, rare members of the class need not be near star-forming regions, and could have any type of host galaxy. Thus a long-duration burst far from any star-forming region would also be a signature of this class. Estimates based on the existence of a known progenitor suggest that our proposed class may be an important contributor to the observed GRB rate.
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| 6. |
- Mandenius, Carl-Fredrik, et al.
(author)
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Quality-by-design for biotechnology-related pharmaceuticals.
- 2009
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In: Biotechnology journal. - : Wiley. - 1860-7314 .- 1860-6768. ; 4:5, s. 600-9
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Journal article (peer-reviewed)abstract
- The following article is a report from a workshop on Quality-by-Design (QbD) held at the 7th European Symposium on Biochemical Engineering Science (7 September 2008, Faro, Portugal).The aim of the workshop was to provide an update on the present status of using QbD in biotechnology-related applications in the pharmaceutical industry. The report summarizes the essential parts of the presentations and covers the industrial, academic, and regulatory aspects of QbD. It concludes with recommendations for further work and development.
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| 8. |
- Olsson, Emma, 1977-, et al.
(author)
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Coagulase-negative staphylococci isolated from sternal wound infections after cardiac surgery : attachment to and accumulation on sternal fixation stainless steel wires
- 2007
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In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - Oxford : Blackwell Publishing. - 0903-4641 .- 1600-0463. ; 115:2, s. 142-151
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Journal article (peer-reviewed)abstract
- Sternal wound infection (SWI) is a serious complication after cardiac surgery. Coagulase-negative staphylococci (CoNS) have been found to be the most common pathogen involved in this postoperative infection related to implanted foreign materials, i.e. sternal fixation wires made from stainless steel. In this study a rapid and simple assay was developed for studying attachment and accumulation of CoNS on stainless steel wires in vitro using [(3)H] thymidine. The method showed a potential to detect differences in the dynamics of the adherence patterns among various CoNS isolates. However, no differences in attachment and accumulation were found between isolates causing deep SWI after cardiac surgery and contaminant isolates. In addition, there were no differences in the distribution of the ica operon between the two groups, as determined by polymerase chain reaction (PCR). Nevertheless, the ability to produce biofilm was found to be present significantly more frequently among SWI isolates than among contaminants.
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| 9. |
- Olsson, Emma, 1977-, et al.
(author)
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Tyrosine transport in fibroblasts from healthy volunteers and patients with schizophrenia
- 2006
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In: Neuroscience Letters. - : Elsevier. - 0304-3940 .- 1872-7972. ; 393, s. 211-215
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Journal article (peer-reviewed)abstract
- Aberrant tyrosine transport across the fibroblast membrane, as measured by lower Vmax and/or lower Km is a repeated finding in patients with schizophrenia. The aim of this study was to investigate the importance of two major transporters, the L- and A-systems and tyrosine transport in fibroblast cell lines from patients with schizophrenia and healthy volunteers. Fibroblast cell lines, n=6 from healthy volunteers and n=6 from patients with schizophrenia, were included in the study. Uptake of [14-C] L-tyrosine in fibroblasts was measured using the cluster tray method in absence and presence of inhibitors. The uptake of tyrosine by the L-system was evaluated with the inhibitor 2-aminobicyclo heptane-2-carboxylic acid (BCH) and the A-system with the inhibitor nonmetabolized methyl-aminoisobutyric acid (MeAIB). Using [14-C] MeAIB the functionality of system A isoform 2, ATA2, was tested. BCH inhibited the uptake of tyrosine with 90%, showing that tyrosine transport in fibroblasts is mainly transported by the L-system. Not more than 10% could be contributed by the A-system. Excess of MeAIB did not influence tyrosine kinetics. Moreover, MeAIB kinetics did not differ between the patients and the controls. In conclusion, aberrant tyrosine transport observed in patients with schizophrenia is probably linked to the one of the L-systems and does not seem to involve the ATA2 transporter.
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