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MR spectroscopy of ...
MR spectroscopy of the human prostate using surface coil at 3 T : Metabolite ratios, age-dependent effects, and diagnostic possibilities
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- Weis, Jan (author)
- Uppsala universitet,Enheten för radiologi
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- Jorulf, Håkan (author)
- Uppsala universitet,Enheten för radiologi
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- Bergman, Antonina (author)
- Uppsala universitet,Enheten för radiologi
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- Ortiz-Nieto, Francisco (author)
- Uppsala universitet,Enheten för radiologi
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- Häggman, Michael (author)
- Uppsala universitet,Urologkirurgi
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- Ahlström, Håkan (author)
- Uppsala universitet,Enheten för radiologi
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(creator_code:org_t)
- 2011-09-23
- 2011
- English.
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In: Journal of Magnetic Resonance Imaging. - : Wiley. - 1053-1807 .- 1522-2586. ; 34:6, s. 1277-1284
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: To measure prostate spectra of healthy volunteers using a surface coil, to demonstrate age-dependent effects, and to investigate diagnostic possibilities for prostate cancer detection. MATERIALS AND METHODS: Single-voxel and 2D magnetic resonance spectroscopic imaging (MRSI) spectra of 51 healthy volunteers with biopsy-proven prostate carcinoma of 20 patients for comparison were measured and processed using the LCModel. The mean normalized spectra and mean metabolite-to-citrate intensity ratios were computed. RESULTS: Metabolite-to-citrate ratios of healthy volunteers were lower in the older group (>51 years) than in the younger group (<45 years). The peripheral zone (PZ) revealed a lower metabolite-to-citrate intensity ratio than the central gland (CG). Age-related differences in metabolite-to-citrate ratio were insignificant in the voxels with predominantly CG tissue, whereas significant differences were found in the PZ. Sensitivity in detecting prostate cancer by single-voxel spectroscopy (SVS) and 2D MRSI was 75% and 80%, respectively. CONCLUSION: SVS and 2D MRSI of the prostate at 3 T, using a surface coil, are useful in situations when insertion of the endorectal coil into the rectum is difficult or impossible. Our findings of age-dependent effects may be of importance for the analysis of patient spectra.
Keyword
- single-voxel spectroscopy
- spectroscopic imaging
- prostate cancer
- 3 Tesla
- LCModel
- surface coil
Publication and Content Type
- ref (subject category)
- art (subject category)
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