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- Leroi, A. M., et al.
(author)
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On revolutions
- 2020
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In: Palgrave Communications. - : Springer Science and Business Media LLC. - 2055-1045. ; 6
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Journal article (peer-reviewed)abstract
- Sometimes the normal course of events is disrupted by a particularly swift and profound change. Historians have often referred to such changes as "revolutions", and, though they have identified many of them, they have rarely supported their claims with statistical evidence. Here, we present a method to identify revolutions based on a measure of multivariate rate of change called Foote novelty. We define revolutions as those periods of time when the value of this measure is, by a non-parametric test, shown to significantly exceed the background rate. Our method also identifies conservative periods when the rate of change is unusually low. We apply it to several quantitative data sets that capture long-term political, social and cultural changes and, in some of them, identify revolutions - both well known and not. Our method is general and can be applied to any phenomenon captured by multivariate time series data of sufficient quality.
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- Tanisawa, K., et al.
(author)
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Sport and exercise genomics: The FIMS 2019 consensus statement update
- 2020
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In: British Journal of Sports Medicine. - : BMJ. - 0306-3674 .- 1473-0480. ; 54:16, s. 969-975
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Journal article (peer-reviewed)abstract
- Rapid advances in technologies in the field of genomics such as high throughput DNA sequencing, big data processing by machine learning algorithms and gene-editing techniques are expected to make precision medicine and gene-therapy a greater reality. However, this development will raise many important new issues, including ethical, moral, social and privacy issues. The field of exercise genomics has also advanced by incorporating these innovative technologies. There is therefore an urgent need for guiding references for sport and exercise genomics to allow the necessary advancements in this field of sport and exercise medicine, while protecting athletes from any invasion of privacy and misuse of their genomic information. Here, we update a previous consensus and develop a guiding reference for sport and exercise genomics based on a SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis. This SWOT analysis and the developed guiding reference highlight the need for scientists/clinicians to be well-versed in ethics and data protection policy to advance sport and exercise genomics without compromising the privacy of athletes and the efforts of international sports federations. Conducting research based on the present guiding reference will mitigate to a great extent the risks brought about by inappropriate use of genomic information and allow further development of sport and exercise genomics in accordance with best ethical standards and international data protection principles and policies. This guiding reference should regularly be updated on the basis of new information emerging from the area of sport and exercise medicine as well as from the developments and challenges in genomics of health and disease in general in order to best protect the athletes, patients and all other relevant stakeholders. © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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- Yuan, Bo, et al.
(author)
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Complex Mixtures of Chlorinated Paraffins Found in Hand Wipes of a Norwegian Cohort
- 2020
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In: Environmental Science and Technology Letters. - : American Chemical Society (ACS). - 2328-8930. ; 7:3, s. 198-205
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Journal article (peer-reviewed)abstract
- Up to 18000 ng of total chlorinated paraffins (CPs) was found in hand wipes of individual adult participants in a Norwegian cohort study (n = 60), with a geometric mean (SD) value of 870 (2700) ng. The CPs covered a wide range of alkane chain lengths from C-7 to C-48 with variable chlorine substitution. Complex mixtures of very-short-chain (vSCCPs, C-<10), short-chain (SCCPs, C10-13), medium-chain (MCCPs, C14-17), and long-chain (LCCPs, C->17) CPs were found, contributing on average 0.3%, 20%, 58%, and 22%, respectively, of the total CPs. Significant positive correlations were found between CP levels and factors related to the indoor environment and product use, including living in a house/apartment built before the ban of SCCPs, having a sofa, the number of TVs in the home, and owning a car, which mirrors CP usage as flame retardants and/or plasticizers in consumer products. Compared to previous studies of other organic contaminants in hand wipe samples from the same cohort, CPs were the most abundant flame retardants. This is the first report of CPs in hand wipes, and dermal exposure based on these data suggested that hand contact could be an important human exposure pathway for LCCPs.
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