Sökning: (WFRF:(Paulsson Karlsson Ylva)) srt2:(2005-2009)
> (2005) >
Differential effect...
Differential effects of TGF-beta1 on telomerase activity in thyroid carcinoma cells
-
- Lindkvist, Anna (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
- Franzén, Åsa (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
- Ren, Zhi-Ping (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
visa fler...
-
- Heldin, Nils-Erik (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
- Paulsson-Karlsson, Ylva (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
-
Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 338:3, s. 1625-1633
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The aim of the present study was to investigate the effect of transforming growth factor-beta1 (TGF-beta1) on telomerase activity in a panel of human anaplastic thyroid carcinoma (ATC) cell lines. Addition of TGF-beta1 decreased the telomerase activity in HTh 74 and KTC-1 cells, while in C 643 and HTh 7 an increased activity was observed. The decreased telomerase activity appeared to be due to transcriptional repression of the hTERT promoter. Addition of a PI-3 kinase inhibitor (LY294002) abrogated the stimulatory effect of TGF-beta1 on the telomerase activity, indicating the possible involvement of hTERT activation via phosphorylation. Furthermore, the MEK-inhibitor U0126 had similar effects suggesting dual regulatory mechanisms. Interestingly, the cell lines differed genetically in that ATC cell lines responding with increased telomerase activity harbored a p53 mutation. In conclusion, TGF-beta1 exerts opposing effects on telomerase activity in ATC cell lines, possibly reflecting deregulation of TGF-beta1 signaling in a more malignant genotype.
Nyckelord
- Anaplastic thyroid carcinoma
- c-Myc
- hTERT promoter
- p53
- Telomerase
- TGF-β1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas