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- Ahluwalia, T. S., et al.
(författare)
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Genome-wide association study of circulating interleukin 6 levels identifies novel loci
- 2021
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Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 30:5, s. 393-409
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Tidskriftsartikel (refereegranskat)abstract
- Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n(discovery)=52654 and n(replication)=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P-combined=1.8x10(-11)), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P-combined=1.5x10(-10)) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P-combined=1.2x10(-122)). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
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- Cleanthous, G., et al.
(författare)
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Regularity, continuity and approximation of isotropic Gaussian random fields on compact two-point homogeneous spaces
- 2020
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Ingår i: Stochastic Processes and their Applications. - : Elsevier BV. - 0304-4149. ; 130:8, s. 4873-4891
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Tidskriftsartikel (refereegranskat)abstract
- Gaussian random fields defined over compact two-point homogeneous spaces are considered and Sobolev regularity and Hölder continuity are explored through spectral representations. It is shown how spectral properties of the covariance function associated to a given Gaussian random field are crucial to determine such regularities and geometric properties. Furthermore, fast approximations of random fields on compact two-point homogeneous spaces are derived by truncation of the series expansion, and a suitable bound for the error involved in such an approximation is provided. © 2020 Elsevier B.V.
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