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- Kremer, B, et al.
(författare)
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Influence of lamotrigine on progression of early Huntington disease : a randomized clinical trial.
- 1999
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Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 53:5, s. 1000-11
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess the efficacy of lamotrigine, a novel antiepileptic drug that inhibits glutamate release, to retard disease progression in Huntington disease (HD).BACKGROUND: Excitatory amino acids may cause selective neuronal death in HD, and lamotrigine may inhibit glutamate release in vivo.METHODS: A double-blinded, placebo-controlled study was conducted of 64 patients with motor signs of less than 5 years' duration who were randomly assigned to either placebo or lamotrigine and assessed at 0 (baseline), 12, 24, and 30 months. The primary response variable was total functional capacity (TFC) score. Secondary response variables included the quantified neurological examination and a set of cognitive and motor tests. Repeated fluorodeoxyglucose measurements of regional cerebral metabolism using PET also were included.RESULTS: Fifty-five patients (28 on lamotrigine, 27 on placebo) completed the study. Neither the primary response variable nor any of the secondary response variables differed significantly between the treatment groups. Both the lamotrigine and the placebo group deteriorated significantly on the TFC, in the lamotrigine group by 1.89 and the placebo group by 2.11 points. No effect of CAG size on the rate of deterioration could be detected.CONCLUSIONS: There was no clear evidence that lamotrigine retarded the progression of early Huntington disease over a period of 30 months. However, more patients on lamotrigine reported symptomatic improvement (53.6 versus 14.8%; p = 0.006), and a trend toward decreased chorea was evident in the treated group (p = 0.08). The study also identified various indices of disease progression, including motor tests and PET studies, that were sensitive to deterioration over time.
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| 5. |
- Bourguet, D, et al.
(författare)
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An insensitive acetylcholinesterase in Culex pipiens (Diptera: Culicidae) from Portugal
- 1996
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Ingår i: JOURNAL OF ECONOMIC ENTOMOLOGY. - : ENTOMOL SOC AMER. - 0022-0493. ; 89:5, s. 1060-1066
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Resistance mechanisms of a strain (PRAIAS) of northern house mosquito, Culex pipiens L., collected in Portugal in 1993, and highly resistant to organophosphates and carbamates were investigated by comparing the resistance characteristics to 3 organophosph
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| 6. |
- CHEVILLON, C, et al.
(författare)
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COMMENSALISM, ADAPTATION AND GENE FLOW - MOSQUITOS OF THE CULEX-PIPIENS COMPLEX IN DIFFERENT HABITATS
- 1995
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Ingår i: GENETICAL RESEARCH. - : CAMBRIDGE UNIV PRESS. - 0016-6723. ; 66:2, s. 147-157
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Two ecotypes have been described for Culex pipiens mosquitoes of the temperate zone: a human commensal type and a feral type, but their degree of evolutionary differentiation and taxonomic status are still unclear. The commensal form is characterized by l
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| 9. |
- Goudet, J, et al.
(författare)
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Testing differentiation in diploid populations
- 1996
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Ingår i: GENETICS. - : GENETICS. - 0016-6731. ; 144:4, s. 1933-1940
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We examine the power of different exact tests of differentiation for diploid populations. Since there is not necessarily random mating within populations, the appropriate hypothesis to construct exact tests is that of independent sampling of genotypes. Th
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| 10. |
- Raymond, M, et al.
(författare)
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Esterase polymorphism in insecticide susceptible populations of the mosquito Culex pipiens
- 1996
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Ingår i: GENETICAL RESEARCH. - : CAMBRIDGE UNIV PRESS. - 0016-6723. ; 67:1, s. 19-26
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Gene amplification involving a particular haplotype has been found at the esterase B locus of mosquitoes from various countries. This similarity has been explained by a unique amplification event followed by migration and selection by organophosphate (OF)
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