Search: (WFRF:(Roach C. M.)) lar1:(lu) hsvcat:3
> (2006-2009) >
Genetic mapping at ...
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.
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Roach, J C (author)
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Deutsch, K (author)
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Li, S (author)
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Siegel, A F (author)
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Bekris, L M (author)
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Einhaus, D C (author)
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Janer, M (author)
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Sheridan, C M (author)
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Glusman, G (author)
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Hood, L (author)
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Study Group., Diabetes Incidence in Sweden (author)
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Study Group, Swedish Childhood Diabetes (author)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 79:4, s. 614-627
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http://dx.doi.org/10...
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http://www.cell.com/...
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Abstract
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- We mapped the genetic influences for type 1 diabetes (T1D), using 2,360 single-nucleotide polymorphism (SNP) markers in the 4.4-Mb human major histocompatibility complex (MHC) locus and the adjacent 493 kb centromeric to the MHC, initially in a survey of 363 Swedish T1D cases and controls. We confirmed prior studies showing association with T1D in the MHC, most significantly near HLA-DR/DQ. In the region centromeric to the MHC, we identified a peak of association within the inositol 1,4,5-triphosphate receptor 3 gene (ITPR3; formerly IP3R3). The most significant single SNP in this region was at the center of the ITPR3 peak of association (P=1.7×10−4 for the survey study). For validation, we typed an additional 761 Swedish individuals. The P value for association computed from all 1,124 individuals was 1.30×10−6 (recessive odds ratio 2.5; 95% confidence interval [CI] 1.7–3.9). The estimated population-attributable risk of 21.6% (95% CI 10.0%–31.0%) suggests that variation within ITPR3 reflects an important contribution to T1D in Sweden. Two-locus regression analysis supports an influence of ITPR3 variation on T1D that is distinct from that of any MHC class II gene.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Roach, J C
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Deutsch, K
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Li, S
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Siegel, A F
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Bekris, L M
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Einhaus, D C
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show more...
-
Janer, M
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Sheridan, C M
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Glusman, G
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Lernmark, Åke
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Hood, L
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Study Group., Di ...
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Study Group, Swe ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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American Journal ...
- By the university
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Lund University