| 1. |
- Bock G., Roberts R.G., Kissling E., Achauer A., Alingahi J., Bruneton M., Friedrich W., Grad M. Guterch A., Hjelt S-E., Hyvönen T., Ikonen J-P., Komminaho K., Korja A, Heikkinen P., Kozolovaskaya E., Nevsky M.V., Pavlenkova N., Pedersen H., Plomerova J.
(författare)
-
Seismic probing of Archean and Proterozoic Lithosphere in Fennoscandia.
- 2001
-
Ingår i: EOS Transactions American Geophysical Union. - : American Geophysical Union. ; 82, s. 621,628-629
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
- Kunkel, E J, et al.
(författare)
-
Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
- 2000
-
Ingår i: Journal of Experimental Medicine. - 1540-9538. ; 192:5, s. 761-768
-
Tidskriftsartikel (refereegranskat)abstract
- The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial lymphocytes and lamina propria lymphocytes migrate to thymus-expressed chemokine (TECK). This attraction is mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor expressed at high levels by essentially all CD4(+) and CD8(+) T lymphocytes in the small intestine. Only a small subset of lymphocytes in the colon are CCR9(+), and lymphocytes from other tissues including tonsils, lung, inflamed liver, normal or inflamed skin, inflamed synovium and synovial fluid, breast milk, and seminal fluid are universally CCR9(-). TECK expression is also restricted to the small intestine: immunohistochemistry reveals that intense anti-TECK reactivity characterizes crypt epithelium in the jejunum and ileum, but not in other epithelia of the digestive tract (including stomach and colon), skin, lung, or salivary gland. These results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Brioni, JD, et al.
(författare)
-
Activation of dopamine D-4 receptors by ABT-724 induces penile erection in rats
- 2004
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences; 1999. - 0027-8424 .- 1091-6490. ; 101:17, s. 6758-6763
-
Tidskriftsartikel (refereegranskat)abstract
- Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype(s) responsible for its erectogenic effect is not known. Here we report that the dopamine D(4) receptor plays a role in the regulation of penile function. ABT-724 is a selective dopamine D(4) receptor agonist that activates human dopamine D(4) receptors with an EC(50) of 12.4 nM and 61% efficacy, with no effect on dopamine D(1), D(2), D(3), or D(5) receptors. ABT-724 dose-dependently facilitates penile erection when given s.c. to conscious rats, an effect that is blocked by haloperidol and clozapine but not by domperidone. A proerectile effect is observed after intracerebroventricular but not intrathecal administration, suggesting a supraspinal site of action. s.c. injections of ABT-724 increase intracavernosal pressure in awake freely moving rats. In the presence of sildenafil, a potentiation of the proerectile effect of ABT-724 is observed in conscious rats. The ability of ABT-724 to facilitate penile erection together with the favorable side-effect profile indicates that ABT-724 could be useful for the treatment of erectile dysfunction.
|
|
| 7. |
- Jenkins, S. R., et al.
(författare)
-
Spatial and temporal variation in settlement and recruitment of the intertidal barnacle Semibalanus balanoides (L.) (Crustacea : Cirripedia) over a European scale
- 2000
-
Ingår i: Journal of Experimental Marine Biology and Ecology. - 0022-0981. ; 243:2, s. 209-225
-
Tidskriftsartikel (refereegranskat)abstract
- Variation in the level of settlement and recruitment in the intertidal barnacle Semibalanus balanoides was studied using a hierarchical sampling programme. The effect of three spatial scales, 10s of metres (sites), 1000s of metres (shores) and 100s of kilometres (locations), was determined. The largest spatial scale represented the distance between four widely separated locations, Sweden, the Isle of Man, SW Ireland and SW England, covering a. large part of the range of S. balanoides in Europe. Temporal variation was determined by comparison between two years, 1997 and 1998. The settlement period of S. balanoides varied in length and timing, being earlier and shorter at the most northerly location, Sweden. The duration of settlement showed little difference among shores within locations, but the pattern of settlement did vary. Estimates of total settlement throughout the settlement period and of recruitment at the end of this period both showed substantial variation among locations which was dependent on the year of study. There was little consistency in the ranking of locations between the two years. Recruitment showed significant variation I the lower spatial scales of shore and site. In addition, examination of variance components showed a high degree of variation between replicates within sites in 1997. There was a significant relationship between settlement and recruitment at three of the four locations. Across all locations variation in settlement explained between 29 and 99% of variation in recruitment. However, locations showed distinct differences in the level of post-settlement survival. (C) 2000 Elsevier Science B.V. All rights reserved.
|
|
| 8. |
|
|
| 9. |
- Scherer, SW, et al.
(författare)
-
Human chromosome 7: DNA sequence and biology
- 2003
-
Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
-
Tidskriftsartikel (refereegranskat)abstract
- DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
|
|
| 10. |
- Wismans, Jac, 1948, et al.
(författare)
-
Development and Evaluation of the ES-2 Dummy
- 2001
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Over the last year, the European Enhanced Vehicle-safety Committee Working Group 12 has assessed and reviewed the performance of the enhanced anthropomorphic test device for lateral impacts, EUROSID-2 (ES-2). The objectives for this work have been the following: - To verify whether the proposed design is addressing the shortcomings of the regulatory test device EUROSID-1 as identified previously by EEVC and NHTSA- To make sure that the original EUROSID-1 biofidelity and performance in normal test conditions is preserved. - To reach a well-balanced conclusion, the working group has undertaken a test program to assess the most important requirements for the ES-2 dummy, biofidelity, sensitivity, repeatability, handling, durability, certification and full-scale performance in comparison with EUROSID-1.In addition, but no less important, the working group has reviewed and explored the findings of full-scale tests conducted at several member organisations within ACEA. ACEA has reported the most important findings in September 2000. Subsequently, WG 12 has further investigated the issues raised in this report. On the basis of this work, the working group has concluded the following with regards to the ES-2 specifications and performance:The ES-2 prototype as tested is superior to current test device EUROSID-1 and, hence, a more appropriate test device for regulatory testing. The important shortcomings of the EUROSID-1 have been satisfactorily addressed with ES-2, whilst biofidelity is maintained, in some areas even somewhat improved. It should be noted, however, that the assessment of thorax biofidelity was based on deflection and force-time data only, and does not incorporate an assessment of V*C. It is recommended to adopt the hardware design without further modification and to use the new proposed certification procedures, with the exception of the high velocity pelvis test.Overall test results in full-scale tests have shown that some critical dummy measurement values for ES-2 have increased compared to EUROSID-1, in particular rib deflection, 17%, and V*C, 23%1 on average. Other values on the other hand have brought down such as the pubic force (10%) due to improved leg interaction. Contrary to the full-scale results, the ES-2 gave equal or lower values for all critical measurements in the biofidelity tests.For the large majority of vehicles tested, the different results would not affect pass or fail with respect to current regulatory limits. It should be noted, however, that, maintaining the rating levels in consumer testing, ES-2 results would lead motoring consumers to believe the protection offered in side impact has decreased while in fact the safety performance of these vehicles has not changed.A force transducer has been developed to measure the force applied to the back plate. It is recommended to use the force transducer in full vehicle assessment.Finally, the working group believes the ES-2 dummy forms a solid basis for interim harmonisation and will further support activities to help realise this objective.
|
|
