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Träfflista för sökning "(WFRF:(Robinson Andreas)) srt2:(2005-2009) srt2:(2007)"

Sökning: (WFRF:(Robinson Andreas)) srt2:(2005-2009) > (2007)

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1.
  • Figtree, G. A., et al. (författare)
  • Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension
  • 2007
  • Ingår i: Journal of Steroid Biochemistry and Molecular Biology. - : Elsevier BV. - 0960-0760 .- 1879-1220. ; 103:2, s. 110-118
  • Tidskriftsartikel (refereegranskat)abstract
    • Given the strong genetic contribution to blood pressure and left ventricular hypertrophy (LVH), and the influence of estrogen on these parameters, we hypothesized that polymorphisms in the estrogen receptor alpha (ERα) promoter may influence LVH. Three novel polymorphisms were identified upstream of the ERα alternatively spliced exon 1E, within sequence which demonstrated significant promoter activity in vitro. Demonstration of ERα E isoform expression in human ventricle by RT-PCR supported a possible functional role for the 1E novel polymorphisms in estrogen signaling in the heart. Indeed, G > A (-721 E) was significantly associated with LVH after controlling for systolic blood pressure and sex in a healthy population (n = 74), contributing to 23% of interventricular septum (IVS) width variance (p < 0.001) and 9.4% of left ventricular mass index (LVMI) variance (p = 0.035). In a separate hypertensive cohort, male carriers of the A allele (n = 8) had a 17% increase in IVS (95% CI: 6-28%) and a 19% increase in LVMI (3-34%) compared to GG homozygotes (n = 84). We conclude that a novel polymorphism in the promoter of a cardiac mRNA splice isoform of ERα is associated with LVH.
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2.
  • Robinson, Yohan, 1977, et al. (författare)
  • Traumatic proximal tibiofibular joint dislocation treated by open reduction and temporary fixation: a case report.
  • 2007
  • Ingår i: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. - : Springer Science and Business Media LLC. - 0942-2056 .- 1433-7347. ; 15:2, s. 199-201
  • Forskningsöversikt (refereegranskat)abstract
    • Isolated dislocations of the proximal tibiofibular joint are a rare condition. Missed diagnosis can lead to chronic knee pain and disability. Early recognition should be followed by immediate closed reduction or open reduction and joint transfixation. We present a young athlete with this injury which was treated successfully by open reduction.
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