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- Scelo, Ghislaine, et al.
(författare)
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Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
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Ingår i: Journal of Allergy and Clinical Immunology: In Practice. - 2213-2198.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Biologic effectiveness is often assessed as response, a term that eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. Objective: To explore definitions of biologic responders in adults with severe asthma and investigate patient characteristics associated with biologic response. Methods: This was a longitudinal cohort study using data from 21 countries, which shared data with the International Severe Asthma Registry. Changes in four asthma outcome domains were assessed in the 1-year period before and after biologic initiation in patients with a predefined level of prebiologic impairment. Responder cutoffs were 50% or greater reduction in exacerbation rate, 50% or greater reduction in long-term oral corticosteroid daily dose, improvement in one or more category in asthma control, and 100 mL or greater improvement in FEV1. Responders were defined using single and multiple domains. The association between prebiologic characteristics and postbiologic initiation response was examined by multivariable analysis. Results: A total of 2,210 patients were included. Responder rate ranged from 80.7% (n = 566 of 701) for exacerbation response to 10.6% (n = 9 of 85) for a four-domain response. Many responders still exhibited significant impairment after biologic initiation: 46.7% (n = 206 of 441) of asthma control responders with uncontrolled asthma before the biologic still had incompletely controlled disease postbiologic initiation. Predictors of response were outcome-dependent. Lung function responders were more likely to have higher prebiologic FeNO (odds ratio = 1.20 for every 25-parts per billion increase), and shorter asthma duration (odds ratio = 0.81 for every 10-year increase in duration). Higher blood eosinophil count and the presence of type 2-related comorbidities were positively associated with higher odds of meeting long-term oral corticosteroid, control, and lung function responder criteria. Conclusions: Our findings underscore the multimodal nature of response, showing that many responders experience residual symptoms after biologic initiation and that predictors of response vary according to the outcome assessed. © 2024 The Authors
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- Abreu, P, et al.
(författare)
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Search for sleptons in e(+)e(-) collisions at root s=183 to 189 GeV
- 2001
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Ingår i: EUROPEAN PHYSICAL JOURNAL C. - : SPRINGER-VERLAG. - 1434-6044. ; 19:1, s. 29-42
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Tidskriftsartikel (refereegranskat)abstract
- Data taken by the DELPHI experiment at centre-of-mass energies of 183 GeV and 189 GeV with a total integrated luminosity of 212 pb(-1) have been used to search for the supersymmetric partners of the electrons, muons, and taus in the context of the Minimal
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- Abdallah, J, et al.
(författare)
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Determination of heavy quark non-perturbative parametersfrom spectral moments in semileptonic B decays
- 2006
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 45:1, s. 35-59
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Tidskriftsartikel (refereegranskat)abstract
- Moments of the hadronic invariant mass and of the lepton energy spectra in semileptonic B decays have been determined with the data recorded by the DELPHI detector at LEP. From measurements of the inclusive b-hadron semileptonic decays, and imposing constraints from other measurements on b- and c-quark masses, the first three moments of the lepton energy distribution and of the hadronic mass distribution, have been used to determine parameters which enter into the extraction of vertical bar V-cb vertical bar from the measurement of the inclusive b-hadron semileptonic decay width. The values obtained in the kinetic scheme are: m(b)(1 GeV) = 4.591 +/- 0.062 +/- 0.039 +/- 0.005 GeV/c(2), m(c)(1 GeV) = 1.170 +/- 0.093 +/- 0.055 +/- 0.005 GeV/c(2), m(pi)(2) (1 GeV) = 0.399 +/- 0.048 +/- 0.034 +/- 0.087 GeV2, (p) over tilde (3)(D) = 0.053 +/- 0.017 +/- 0.011 +/- 0.026 GeV3, and include corrections at order 1/m(b)(3). Using these results, and present measurements of the inclusive semileptonic decay partial width of b-hadrons at LEP, an accurate determination of vertical bar V-cb vertical bar is obtained: vertical bar V-cb vertical bar = 0.0421 x (1 +/- 0.014 (meas center dot) +/- 0.014 (fit) +/- 0.015 (th center dot)).
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- Abdallah, J., et al.
(författare)
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Di-jet production in gamma gamma collisions at LEP2
- 2008
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; C:58, s. 531-541
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Tidskriftsartikel (refereegranskat)
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- Abdallah, J, et al.
(författare)
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Search for eta(b) in two-photon collisions at LEP II with the DELPHI detector
- 2006
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 634:4, s. 340-346
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Tidskriftsartikel (refereegranskat)abstract
- The pseudoscalar meson eta(b) has been searched for in two-photon interactions at LEP II. The data sample corresponds to a total integrated luminosity of 617 pb(-1) at centre-of-mass energies ranging from 161 to 209 GeV. Upper limits at a confidence level of 95% on the product Gamma(gamma gamma) (eta(b)) x BR(eta(b)) are 190, 470 and 660 eV/c(2) for the eta(b) decaying into 4, 6 and 8 charged particles, respectively.
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