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Sökning: (WFRF:(Roth M.)) srt2:(2000-2004) > (2002)

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1.
  • Sohler, D, et al. (författare)
  • Neutron Excitations Across the N=50 Shell Gap in 102In
  • 2002
  • Ingår i: Nuclear Physics, Section A. - : Elsevier. - 0375-9474 .- 1873-1554. ; 708:3-4, s. 181-189
  • Tidskriftsartikel (refereegranskat)abstract
    • The structure of In-102 has been investigated by in-beam gamma-spectroscopic methods. Knowledge on the excited states of this nucleus has significantly been extended. Three cascades of transitions were observed to exceed the spin-energy domain spanned by the pig(9/2)(-1)v(d(5/2),g(7/2))(3) configurations. The new high spin states at similar to 4 MeV excitation energy could be assigned to the pig(9/2)(-1)v(d(5/2), g(7/2))(2)h (11/2) configuration, while at least those at 4.733, 5.192 and 5.853 MeV most likely arise from the vg(9/2) --> vd(5/2), g(7/2) one-particle-one-hole excitation across the N = 50 shell closure.
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2.
  • Salovaara, R., et al. (författare)
  • Frequent loss of SMAD4/DPC4 protein in colorectal cancers
  • 2002
  • Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 51:1, s. 56-59
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND AIMS: Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a minor subset of colorectal carcinomas as well as in germlines of humans predisposed to colon tumours. PATIENTS AND METHODS: The involvement of SMAD4 in sporadic colorectal neoplasia was evaluated by immunohistochemistry in 53 unselected cases and 27 cases displaying microsatellite instability. RESULTS: SMAD4 expression was absent in 20 of 53 (38%) unselected colorectal carcinomas, and reduced in another 15 (28%) cases. However, 26 of 27 cancers displaying microsatellite instability and TGF-betaIIR mutations were positive for SMAD4 immunostaining. CONCLUSIONS: Loss of SMAD4 expression may play a more prominent role in colon cancer than anticipated based on genetic evidence, but not in mutator phenotype tumours.
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  • Resultat 1-4 av 4

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