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Obesity, metabolic ...
Obesity, metabolic factors and risk of different histological types of lung cancer : a Mendelian randomization study
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- Carreras-Torres, Robert (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Haycock, Philip C. (författare)
- University of Bristol,Fred Hutchinson Cancer Research Center
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- Wade, Kaitlin H. (författare)
- University of Bristol
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- Relton, Caroline L. (författare)
- University of Bristol
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- Martin, Richard M. (författare)
- University of Bristol
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- Smith, George Davey (författare)
- University of Bristol
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- Albanes, Demetrius (författare)
- National Cancer Institute, USA
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- Aldrich, Melinda C. (författare)
- Vanderbilt University
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- Andrew, Angeline (författare)
- Norris Cotton Cancer Center,Dartmouth College,University of Liverpool,Radboud University Medical Center
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- Arnold, Susanne M. (författare)
- University of Kentucky
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- Bickeböller, Heike (författare)
- University of Göttingen
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- Bojesen, Stig E. (författare)
- University of Copenhagen
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- Brunnström, Hans (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Regional Laboratories Region Skåne
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Regional Laboratories Region Skåne
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- Brüske, Irene (författare)
- Helmholtz Zentrum München
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- Caporaso, Neil E. (författare)
- National Cancer Institute, NCI
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- Chen, Chu (författare)
- Harvard T.H. Chan School of Public Health,Harvard Medical School
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Christiani, David C. (författare)
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- Christian, W. Jay (författare)
- University of Kentucky
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Doherty, Jennifer A. (författare)
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- Duell, Eric J. (författare)
- Catalan Institute of Oncology
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- Field, John K. (författare)
- University of Liverpool
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Davies, Michael P. A. (författare)
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- Marcus, Michael W. (författare)
- University of Liverpool
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- Goodman, Gary E. (författare)
- Fred Hutchinson Cancer Research Center
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- Grankvist, Kjell (författare)
- Umeå University,Umeå universitet,Klinisk kemi
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- Haugen, Aage (författare)
- National Institute of Occupational Health, Norway
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- Hong, Yun-Chul (författare)
- Seoul National University
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Kiemeney, Lambertus A. (författare)
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- van der Heijden, Erik H. F. M. (författare)
- Radboud University Medical Center
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- Kraft, Peter (författare)
- Harvard T.H. Chan School of Public Health
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- Johansson, Mikael B. (författare)
- Umeå University,Umeå universitet,Onkologi
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- Lam, Stephen (författare)
- British Columbia Cancer Agency
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- Landi, Maria Teresa (författare)
- National Cancer Institute, USA
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- Lazarus, Philip (författare)
- Washington State University College of Pharmacy
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- Le Marchand, Loïc (författare)
- University of Hawaii Cancer Center
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- Liu, Geoffrey (författare)
- Princess Margaret Hospital University of Toronto
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Park, Sungshim L. (författare)
- University of Southern California
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- Rennert, Gad (författare)
- Technion - Israel Institute of Technology
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- Risch, Angela (författare)
- University of Salzburg
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- Haura, Eric B. (författare)
- H. Lee Moffitt Cancer Center & Research Institute
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- Scelo, Ghislaine (författare)
- International Agency for Research on Cancer, World Health Organization
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- Zaridze, David (författare)
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
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- Mukeriya, Anush (författare)
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
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- Savić, Milan (författare)
- Clinical Center of Serbia
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- Lissowska, Jolanta (författare)
- The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
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- Swiatkowska, Beata (författare)
- Nofer Institute of Occupational Medicine
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- Janout, Vladimir (författare)
- University of Ostrava
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- Holcatova, Ivana (författare)
- Charles University in Prague
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- Mates, Dana (författare)
- National Institute of Public Health, Romania
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- Schabath, Matthew B. (författare)
- H. Lee Moffitt Cancer Center & Research Institute
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- Shen, Hongbing (författare)
- Nanjing Medical University
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- Tardon, Adonina (författare)
- University of Oviedo
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- Teare, Dawn (författare)
- University of Sheffield
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- Woll, Penella (författare)
- University of Sheffield
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- Tsao, Ming-Sound (författare)
- Princess Margaret Hospital University of Toronto
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- Wu, Xifeng (författare)
- University of Texas
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- Yuan, Jian-Min (författare)
- University of Pittsburgh Cancer Institute
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- Hung, Rayjean J. (författare)
- Mount Sinai Hospital of University of Toronto
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- Amos, Christopher I. (författare)
- Dartmouth College
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- McKay, James (författare)
- International Agency for Research on Cancer, World Health Organization
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- Brennan, Paul (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2017-06-08
- 2017
- Engelska.
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Ingår i: PLOS ONE. - : Public library science. - 1932-6203. ; 12:6
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. Methods and findings: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01-1.43] and for small cell lung cancer (OR [95% CI] = 1.52 [1.15-2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m(2)]), but not for adenocarcinoma (OR [95% CI] = 0.93 [0.79-1.08]) (P-heterogeneity = 4.3x10(-3)). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10(-3)), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95% CI] = 0.90 [0.84-0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95% CI] = 1.63 [1.25-2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results. Conclusions: Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Carreras-Torres, ...
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Johansson, Matti ...
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Haycock, Philip ...
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Wade, Kaitlin H.
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Relton, Caroline ...
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Martin, Richard ...
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visa fler...
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Smith, George Da ...
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Albanes, Demetri ...
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Aldrich, Melinda ...
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Andrew, Angeline
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Arnold, Susanne ...
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Bickeböller, Hei ...
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Bojesen, Stig E.
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Brunnström, Hans
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Manjer, Jonas
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Brüske, Irene
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Caporaso, Neil E ...
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Chen, Chu
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Christiani, Davi ...
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Christian, W. Ja ...
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Doherty, Jennife ...
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Duell, Eric J.
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Field, John K.
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Davies, Michael ...
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Marcus, Michael ...
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Goodman, Gary E.
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Grankvist, Kjell
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Haugen, Aage
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Hong, Yun-Chul
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Kiemeney, Lamber ...
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van der Heijden, ...
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Kraft, Peter
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Johansson, Mikae ...
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Lam, Stephen
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Landi, Maria Ter ...
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Lazarus, Philip
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Le Marchand, Loï ...
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Liu, Geoffrey
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Melander, Olle
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Park, Sungshim L ...
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Rennert, Gad
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Risch, Angela
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Haura, Eric B.
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Scelo, Ghislaine
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Zaridze, David
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Mukeriya, Anush
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Savić, Milan
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Lissowska, Jolan ...
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Swiatkowska, Bea ...
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Janout, Vladimir
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Holcatova, Ivana
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Mates, Dana
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Schabath, Matthe ...
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Shen, Hongbing
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Tardon, Adonina
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Teare, Dawn
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Woll, Penella
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Tsao, Ming-Sound
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Wu, Xifeng
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Yuan, Jian-Min
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Hung, Rayjean J.
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Amos, Christophe ...
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McKay, James
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Brennan, Paul
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