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Large-Scale Gene-Ce...
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
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Asselbergs, Folkert W. (author)
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Guo, Yiran (author)
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van Iperen, Erik P. A. (author)
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show more...
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Sivapalaratnam, Suthesh (author)
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Tragante, Vinicius (author)
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Lanktree, Matthew B. (author)
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Lange, Leslie A. (author)
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Almoguera, Berta (author)
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Appelman, Yolande E. (author)
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Barnard, John (author)
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Baumert, Jens (author)
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Beitelshees, Amber L. (author)
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Bhangale, Tushar R. (author)
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Chen, Yii-Der Ida (author)
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Gaunt, Tom R. (author)
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Gong, Yan (author)
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Hopewell, Jemma C. (author)
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Johnson, Toby (author)
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Kleber, Marcus E. (author)
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Langaee, Taimour Y. (author)
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Li, Mingyao (author)
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Li, Yun R. (author)
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Liu, Kiang (author)
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McDonough, Caitrin W. (author)
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Meijs, Matthijs El. (author)
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Middelberg, Rita P. S. (author)
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Musunuru, Kiran (author)
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Nelson, Christopher P. (author)
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O'Connell, Jeffery R. (author)
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Padmanabhan, Sandosh (author)
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Pankow, James S. (author)
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Pankratz, Nathan (author)
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Rafelt, Suzanne (author)
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Rajagopalan, Ramakrishnan (author)
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Romaine, Simon P. R. (author)
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Schork, Nicholas J. (author)
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Shaffer, Jonathan (author)
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Shen, Haiqing (author)
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Smith, Erin N. (author)
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Tischfield, Sam E. (author)
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van der Most, Peter J. (author)
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van Vliet-Ostaptchouk, Jana V. (author)
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Verweij, Niek (author)
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Volcik, Kelly A. (author)
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Zhang, Li (author)
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Bailey, Kent R. (author)
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Bailey, Kristian M. (author)
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Bauer, Florianne (author)
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Boer, Jolanda M. A. (author)
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Braund, Peter S. (author)
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Burt, Amber (author)
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Burton, Paul R. (author)
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Buxbaum, Sarah G. (author)
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Chen, Wei (author)
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Cooper-DeHoff, Rhonda M. (author)
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Cupples, L. Adrienne (author)
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deJong, Jonas S. (author)
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Delles, Christian (author)
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Duggan, David (author)
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Fornage, Myriam (author)
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Furlong, Clement E. (author)
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Glazer, Nicole (author)
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Gums, John G. (author)
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Hastie, Claire (author)
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Holmes, Michael V. (author)
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Illig, Thomas (author)
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Kirkland, Susan A. (author)
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Kivimaki, Mika (author)
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Klein, Ronald (author)
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Klein, Barbara E. (author)
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Kooperberg, Charles (author)
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Kottke-Marchant, Kandice (author)
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Kumari, Meena (author)
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LaCroix, Andrea Z. (author)
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Mallela, Laya (author)
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Murugesan, Gurunathan (author)
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Ordovas, Jose (author)
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Ouwehand, Willem H. (author)
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Post, Wendy S. (author)
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Saxena, Richa (author)
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Scharnagl, Hubert (author)
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Schreiner, Pamela J. (author)
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Shah, Tina (author)
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Shields, Denis C. (author)
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Shimbo, Daichi (author)
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Srinivasan, Sathanur R. (author)
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Stolk, Ronald P. (author)
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Swerdlow, Daniel I. (author)
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Taylor Jr, Herman A. (author)
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Topo, Eric J. (author)
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Toskala, Elina (author)
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van Pelt, Joost L. (author)
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van Setten, Jessica (author)
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Yusuf, Salim (author)
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Whittaker, John C. (author)
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Zwinderman, A. H. (author)
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Anand, Sonia S. (author)
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Balmforth, Anthony J. (author)
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Berenson, Gerald S. (author)
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Bezzina, Connie R. (author)
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Boehm, Bernhard O. (author)
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Boerwinkle, Eric (author)
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Casas, Juan P. (author)
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Caulfield, Mark J. (author)
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Clarke, Robert (author)
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Connell, John M. (author)
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Cruickshanks, Karen J. (author)
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Davidson, Karina W. (author)
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Day, Ian N. M. (author)
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de Bakker, Paul I. W. (author)
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Doevendans, Pieter A. (author)
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Dominiczak, Anna E. (author)
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Hall, Alistair S. (author)
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Hartman, Catharina A. (author)
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Hengstenberg, Christian (author)
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Hillege, Hans L. (author)
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Hofker, Marten H. (author)
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Humphries, Steve E. (author)
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Jarvik, Gail P. (author)
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Johnson, Julie A. (author)
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Kaess, Bernhard M. (author)
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Kathiresan, Sekar (author)
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Koenig, Wolfgang (author)
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Lawlor, Debbie A. (author)
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Maerz, Winfried (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Mitchell, Braxton D. (author)
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Montgomery, Grant W. (author)
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Munroe, Patricia B. (author)
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Murray, Sarah S. (author)
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Newhouse, Stephen J. (author)
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Onland-Moret, N. Charlotte (author)
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Poulter, Neil (author)
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Psaty, Bruce (author)
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Redline, Susan (author)
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Rich, Stephen S. (author)
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Rotter, Jerome I. (author)
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Schunkert, Heribert (author)
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Sever, Peter (author)
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Shuldiner, Alan R. (author)
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Silverstein, Roy L. (author)
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Stanton, Alice (author)
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Thorand, Barbara (author)
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Trip, Mieke D. (author)
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Tsai, Michael Y. (author)
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van der Harst, Pim (author)
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van der Schoot, Ellen (author)
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van der Schouw, Yvonne T. (author)
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Verschuren, W. M. Monique (author)
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Watkins, Hugh (author)
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Wilde, Arthur A. M. (author)
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Wolffenbuttel, Bruce H. R. (author)
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Whitfield, John B. (author)
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Hovingh, G. Kees (author)
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Ballantyne, Christie M. (author)
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Wijmenga, Cisca (author)
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Reilly, Muredach P. (author)
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Martin, Nicholas G. (author)
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Wilson, James G. (author)
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Rader, Daniel J. (author)
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Samani, Nilesh J. (author)
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Reiner, Alex P. (author)
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Hegele, Robert A. (author)
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Kastelein, John J. P. (author)
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Hingorani, Aroon D. (author)
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Talmud, Philippa J. (author)
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Hakonarson, Hakon (author)
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Elbers, Clara C. (author)
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Keating, Brendan J. (author)
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Drenos, Fotios (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 91:5, s. 823-838
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Asselbergs, Folk ...
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Guo, Yiran
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van Iperen, Erik ...
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Sivapalaratnam, ...
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Tragante, Vinici ...
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Lanktree, Matthe ...
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show more...
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Lange, Leslie A.
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Almoguera, Berta
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Appelman, Yoland ...
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Barnard, John
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Baumert, Jens
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Beitelshees, Amb ...
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Bhangale, Tushar ...
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Chen, Yii-Der Id ...
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Gaunt, Tom R.
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Gong, Yan
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Hopewell, Jemma ...
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Johnson, Toby
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Kleber, Marcus E ...
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Langaee, Taimour ...
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Li, Mingyao
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Li, Yun R.
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Liu, Kiang
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McDonough, Caitr ...
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Meijs, Matthijs ...
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Middelberg, Rita ...
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Musunuru, Kiran
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Nelson, Christop ...
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O'Connell, Jeffe ...
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Padmanabhan, San ...
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Pankow, James S.
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Pankratz, Nathan
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Rafelt, Suzanne
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Rajagopalan, Ram ...
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Romaine, Simon P ...
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Schork, Nicholas ...
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Shaffer, Jonatha ...
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Shen, Haiqing
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Smith, Erin N.
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Tischfield, Sam ...
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van der Most, Pe ...
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van Vliet-Ostapt ...
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Verweij, Niek
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Volcik, Kelly A.
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Zhang, Li
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Bailey, Kent R.
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Bailey, Kristian ...
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Bauer, Florianne
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Boer, Jolanda M. ...
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Braund, Peter S.
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Burt, Amber
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Burton, Paul R.
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Buxbaum, Sarah G ...
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Chen, Wei
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Cooper-DeHoff, R ...
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Cupples, L. Adri ...
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deJong, Jonas S.
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Delles, Christia ...
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Duggan, David
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Fornage, Myriam
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Furlong, Clement ...
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Glazer, Nicole
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Gums, John G.
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Hastie, Claire
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Holmes, Michael ...
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Illig, Thomas
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Kirkland, Susan ...
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Kivimaki, Mika
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Klein, Ronald
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Klein, Barbara E ...
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Kooperberg, Char ...
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Kottke-Marchant, ...
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Kumari, Meena
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LaCroix, Andrea ...
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Mallela, Laya
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Murugesan, Gurun ...
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Ordovas, Jose
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Ouwehand, Willem ...
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Post, Wendy S.
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Saxena, Richa
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Scharnagl, Huber ...
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Schreiner, Pamel ...
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Shah, Tina
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Shields, Denis C ...
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Shimbo, Daichi
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Srinivasan, Sath ...
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Stolk, Ronald P.
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Swerdlow, Daniel ...
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Taylor Jr, Herma ...
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Topo, Eric J.
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Toskala, Elina
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van Pelt, Joost ...
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van Setten, Jess ...
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Yusuf, Salim
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Whittaker, John ...
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Zwinderman, A. H ...
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Anand, Sonia S.
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Balmforth, Antho ...
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Berenson, Gerald ...
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Bezzina, Connie ...
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Boehm, Bernhard ...
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Boerwinkle, Eric
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Casas, Juan P.
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Caulfield, Mark ...
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Clarke, Robert
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Connell, John M.
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Cruickshanks, Ka ...
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Davidson, Karina ...
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Day, Ian N. M.
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de Bakker, Paul ...
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Doevendans, Piet ...
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Dominiczak, Anna ...
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Hall, Alistair S ...
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Hartman, Cathari ...
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Hengstenberg, Ch ...
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Hillege, Hans L.
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Hofker, Marten H ...
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Humphries, Steve ...
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Jarvik, Gail P.
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Johnson, Julie A ...
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Kaess, Bernhard ...
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Kathiresan, Seka ...
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Koenig, Wolfgang
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Lawlor, Debbie A ...
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Maerz, Winfried
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Melander, Olle
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Mitchell, Braxto ...
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Montgomery, Gran ...
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Munroe, Patricia ...
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Murray, Sarah S.
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Newhouse, Stephe ...
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Onland-Moret, N. ...
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Poulter, Neil
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Psaty, Bruce
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Redline, Susan
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Rich, Stephen S.
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Rotter, Jerome I ...
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Schunkert, Herib ...
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Sever, Peter
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Shuldiner, Alan ...
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Silverstein, Roy ...
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Stanton, Alice
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Thorand, Barbara
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Trip, Mieke D.
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Tsai, Michael Y.
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van der Harst, P ...
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van der Schoot, ...
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van der Schouw, ...
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Verschuren, W. M ...
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Watkins, Hugh
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Wilde, Arthur A. ...
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Wolffenbuttel, B ...
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Whitfield, John ...
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Hovingh, G. Kees
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Ballantyne, Chri ...
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Wijmenga, Cisca
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Reilly, Muredach ...
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Martin, Nicholas ...
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Wilson, James G.
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Rader, Daniel J.
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Samani, Nilesh J ...
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Reiner, Alex P.
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Hegele, Robert A ...
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Kastelein, John ...
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Hingorani, Aroon ...
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Talmud, Philippa ...
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Hakonarson, Hako ...
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Elbers, Clara C.
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Keating, Brendan ...
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Drenos, Fotios
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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American Journal ...
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Lund University