| 1. |
- Molassiotis, A., et al.
(författare)
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Use of complementary and alternative medicine in cancer patients : a European survey
- 2005
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Ingår i: Annals of Oncology. - : Oxford University Press. - 0923-7534 .- 1569-8041. ; 16:4, s. 655-663
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Tidskriftsartikel (refereegranskat)abstract
- Background: The aim of this study was to explore the use of complementary and alternative medicine (CAM) in cancer patients across a number of European countries.Methods: A descriptive survey design was developed. Fourteen countries participated in the study and data was collected through a descriptive questionnaire from 956 patients.Results: Data suggest that CAM is popular among cancer patients with 35.9% using some form of CAM (range among countries 14.8% to 73.1%). A heterogeneous group of 58 therapies were identified as being used. Herbal medicines and remedies were the most commonly used CAM therapies, together with homeopathy, vitamins/minerals, medicinal teas, spiritual therapies and relaxation techniques. Herbal medicine use tripled from use before diagnosis to use since diagnosis with cancer. Multivariate analysis suggested that the profile of the CAM user was that of younger people, female and with higher educational level. The source of information was mainly from friends/family and the media, while physicians and nurses played a small part in providing CAM-related information. The majority used CAM to increase the body's ability to fight cancer or improve physical and emotional well-being, and many seemed to have benefited from using CAM (even though the benefits were not necessarily related to the initial reason for using CAM). Some 4.4% of patients, however, reported side-effects, mostly transient.Conclusions: It is imperative that health professionals explore the use of CAM with their cancer patients, educate them about potentially beneficial therapies in light of the limited available evidence of effectiveness, and work towards an integrated model of health-care provision.
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| 2. |
- Li, Aihong, et al.
(författare)
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Distinctive IGH gene segment usage and minimal residual disease detection in infant acute lymphoblastic leukaemias.
- 2005
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 131:2, s. 185-92
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Tidskriftsartikel (refereegranskat)abstract
- Infant acute lymphoblastic leukaemia (ALL) represents a rare but unique subset with poor prognosis. We analysed mixed-lineage leukaemia (MLL) gene rearrangements and the sequences of complete and incomplete immunoglobulin heavy chain gene rearrangements (IGH) in 14 infants (age < or = 12 months at diagnosis) enrolled on Dana-Farber Cancer Institute ALL Consortium Protocol 95-01. The dynamics of the leukaemic clone were followed during the course of the disease by quantitative real-time polymerase chain reaction of IGH rearrangements. Sixteen sequences were obtained from 13 (93%) of these infants. There was marked over usage of the V(H)6.1 gene segment (64%) in infants compared with older children with ALL (8%), (P < 0.001) and overusage of D(H)6 (P = 0.004) and J(H)1 (P = 0.004). Poor outcome was associated with MLL gene rearrangements rather than any specific V(H)D(H)J(H) gene usage patterns. Levels of minimal residual disease (MRD) at the end of induction appeared to be high in infants with ALL compared with older children, and although the number of infant cases studied was small, there were no differences in MRD levels after induction therapy in infant ALL with or without MLL gene rearrangements (P = 0.41) and quantitative MRD assessment at the early time points may not be predictive of outcome. Novel treatment strategies are required to improve the outcome in this poor prognosis subset of children with ALL.
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| 3. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 4. |
- Lorenz, Henning, 1972-
(författare)
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Eurasian Arctic Tectonics: Geology of Severnaya Zemlya (North Kara Terrane) and Relationships to the Timanide Margin of Baltica
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The North Kara Terrane (NKT), with Severnaya Zemlya as its main outcrop area, constitutes the Palaeozoic and older rocks of the northern part of the Kara Shelf. Potential field data suggest a continuation into the eastern Barents Shelf. Several lines of evidence imply that the NKT was a part of Baltica at least during the latter part of the Neoproterozoic, and probably was influenced by Timanian orogeny.The Timanide type area is characterised by metaturbidites from the pre-Timanian passive margin of the East European Craton (EEC). Regional amphibolite facies metamorphism, as exposed on Kanin Peninsula, was probably followed by near-isothermal decompression. It is inferred that these conditions were reached by depression beneath the accreted outboard terranes. Subsequently, the metaturbidites were thrust into their present position onto the EEC’s pericratonic unmetamorphosed shelf sediments. The thrusting was accompanied by rapid exhumation. About 560 Ma late-orogenic granites intrude the Timanian accreted terranes.On Severnaya Zemlya, Neoproterozoic turbidites, containing ca. 560 Ma zircons, are overlain by shelf deposits, which dominate the Palaeozoic until the end of the Silurian. The succession is interrupted by the regional Kan’on (canyon) River Unconformity and probably by a late Neoproterozoic unconformity. New U-Th-Pb ion-microprobe isotope-ages on volcanics and faunal evidence imply that the Kan'on River Unconformity developed in a short time span around the Cambrian-Ordovician boundary. Other isotope-ages demonstrate that intense igneous activity, which has been inferred to be related to rifting within the NKT, extended into the Arenig and was contemporaneous with the development of Baltica’s northeastern passive margin. Zircon xenocrysts (ca. 540 - 580 Ma) in these igneous rocks indicate a Timanian component in the crust below the Severnaya Zemlya Archipelago. In the latest Silurian, Old Red Sandstone facies sedimentation began with the migration of an inferred Caledonian foreland basin into the area of Severnaya Zemlya. The Caledonian deformation front overrode the area in the latest Devonian or earliest Carboniferous.The inferred late Caledonian deformation terminated, according to biostratigraphy and new isotope-ages from Bol'shevik Island granites, before the end of the Visean (ca. 345 Ma). Thus, the Uralian collision between the NKT and Siberia (ca. 300 Ma) apparently did not affect the Severnaya Zemlya Archipelago.
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| 5. |
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| 6. |
- Natiello, Mario, et al.
(författare)
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Winding Numbers
- 2005
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Ingår i: Encyclopedia of Nonlinear Science. - 1579583857 ; , s. 998-1000
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Solari, H. G., et al.
(författare)
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Lasers
- 2005
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Ingår i: Encyclopedia of Nonlinear Science. - 1579583857 ; , s. 520-522
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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