↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "(WFRF:(Sellgren CM)) srt2:(2022) srt2:(2022)"

Search: (WFRF:(Sellgren CM)) srt2:(2022) > (2022)

Result 1-5 of 5

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	, amudyata, et al. (author) SARS-CoV-2 promotes microglial synapse elimination in human brain organoids 2022 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 2827:210, s. 3939-3950 Journal article (peer-reviewed)abstract Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection initiate neuronal cell death and cause a loss of post-synaptic termini. Despite limited neurotropism and a decelerating viral replication, we observe a threefold increase in microglial engulfment of postsynaptic termini after SARS-CoV-2 exposure. We define the microglial responses to SARS-CoV-2 infection by single cell transcriptomic profiling and observe an upregulation of interferon-responsive genes as well as genes promoting migration and synapse engulfment. To a large extent, SARS-CoV-2 exposed microglia adopt a transcriptomic profile overlapping with neurodegenerative disorders that display an early synapse loss as well as an increased incident risk after a SARS-CoV-2 infection. Our results reveal that brain organoids infected with SARS-CoV-2 display disruption in circuit integrity via microglia-mediated synapse elimination and identifies a potential novel mechanism contributing to cognitive impairments in patients recovering from COVID-19.
2.	Erhardt, S, et al. (author) Proteomic Plasma Profiling of Patients With First-Episode Psychosis Identifies Inflammatory Markers Associated With Illness Severity 2022 In: NEUROPSYCHOPHARMACOLOGY. - 0893-133X. ; 47, s. 378-379 Conference paper (other academic/artistic)
3.	Samudyata,, et al. (author) SARS-CoV-2 promotes microglial synapse elimination in human brain organoids 2022 In: Molecular psychiatry. - 1476-5578. Journal article (peer-reviewed)
4.	Youhanna, S, et al. (author) Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives 2022 In: Pharmacological reviews. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 1521-0081 .- 0031-6997. ; 74:1, s. 141-206 Journal article (peer-reviewed)
5.	Youhanna, S, et al. (author) Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives 2022 In: Pharmacological reviews. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 1521-0081 .- 0031-6997. ; 74:1, s. 141-206 Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-5 of 5

Refine your search

Type of publication: journal article (4); conference paper (1)

Type of content: peer-reviewed (4); other academic/artistic (1)

Author/Editor: Sellgren, CM (5); Goparaju, SK (4); Orhan, F (3); Lauschke, VM (2); Schalling, M (2); Sheridan, SD (2); show more...; Oliveira, AO (2); Malwade, S (2); Gracias, J (2); Steponaviciute, L (2); Perlis, RH (2); Rothfuchs, AG (2); Shen, JX (2); Youhanna, S (2); Kemas, AM (2); Shafagh, RZ (2); Preiss, L (2); Cakal, SD (2); Paqualini, FS (2); Lind, JU (2); Zhou, Y. (1); Piehl, F (1); Erhardt, S (1); , amudyata (1); de Sousa, NR (1); Schwieler, L (1); Engberg, G (1); Bergman, HF (1); Cervenka, S (1); Zhou, YT (1); Eren, F (1); Samudyata, (1); Rufino de Sousa, N (1); show less...

University: Karolinska Institutet (5)

Language: English (5)

Year: 2022 (5)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view