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Pooled analyses of ...
Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer
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- Kim, Dong-Hyun (författare)
- Hallym Univ, Dept Social & Prevent Med, Coll Med, Chunchon, South Korea.
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- Smith-Warner, Stephanie A. (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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- Spiegelman, Donna (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
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- Yaun, Shiaw-Shyuan (författare)
- Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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- Colditz, Graham A. (författare)
- Washington Univ, Sch Med, Inst Publ Hlth, St Louis, MO USA.
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- Freudenheim, Jo L. (författare)
- SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
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- Giovannucci, Edward (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
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- Goldbohm, R. Alexandra (författare)
- TNO Qual Life, Dept Prevent & Hlth, Leiden, Netherlands.
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- Graham, Saxon (författare)
- SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
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- Harnack, Lisa (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
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- Jacobs, Eric J. (författare)
- Amer Canc Soc, Atlanta, GA 30329 USA.
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- Leitzmann, Michael (författare)
- Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany.
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- Mannisto, Satu (författare)
- Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.
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- Miller, Anthony B. (författare)
- Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
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- Potter, John D. (författare)
- Fred Hutchinson Canc Res Ctr, Div Publ Hlth Serv, Seattle, WA 98104 USA.
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- Rohan, Thomas E. (författare)
- Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
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- Schatzkin, Arthur (författare)
- NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
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- Speizer, Frank E. (författare)
- Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
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- Stevens, Victoria L. (författare)
- Amer Canc Soc, Atlanta, GA 30329 USA.
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Stolzenberg-Solomon, Rachael (författare)
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- Terry, Paul (författare)
- Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
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- Toniolo, Paolo (författare)
- NYU, Dept Environm Med, New York, NY 10016 USA.
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- Weijenberg, Matty P. (författare)
- Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.
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- Willett, Walter C. (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Zeleniuch-Jacquotte, Anne (författare)
- NYU, Dept Environm Med, New York, NY 10016 USA.
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- Hunter, David J. (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
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Hallym Univ, Dept Social & Prevent Med, Coll Med, Chunchon, South Korea Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. (creator_code:org_t)
- 2010-09-05
- 2010
- Engelska.
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Ingår i: Cancer Causes and Control. - : SPRINGER. - 0957-5243 .- 1573-7225. ; 21:11, s. 1919-1930
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing a parts per thousand yen560 mcg/days vs. < 240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 mu g/day increase in total folate intake. These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Colon cancer
- Folate
- Cohort studies
- Meta-analysis
- Pooled analysis
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Kim, Dong-Hyun
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Smith-Warner, St ...
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Spiegelman, Donn ...
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Yaun, Shiaw-Shyu ...
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Colditz, Graham ...
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Freudenheim, Jo ...
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visa fler...
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Giovannucci, Edw ...
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Goldbohm, R. Ale ...
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Graham, Saxon
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Harnack, Lisa
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Jacobs, Eric J.
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Leitzmann, Micha ...
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Mannisto, Satu
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Miller, Anthony ...
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Potter, John D.
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Rohan, Thomas E.
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Schatzkin, Arthu ...
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Speizer, Frank E ...
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Stevens, Victori ...
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Stolzenberg-Solo ...
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Terry, Paul
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Toniolo, Paolo
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Weijenberg, Matt ...
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Willett, Walter ...
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Wolk, Alicja
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Zeleniuch-Jacquo ...
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Hunter, David J.
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Cancer Causes an ...
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