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Concentrations of p...
Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer
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Hardell, L (author)
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van Bavel, B (author)
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Lindstrom, G (author)
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Carlberg, M (author)
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Dreifaldt, AC (author)
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Wijkstrom, H (author)
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- Starkhammar, Hans, 1948- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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Hallquist, A (author)
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Kolmert, T (author)
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(creator_code:org_t)
- Wiley, 2004
- 2004
- English.
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In: International Journal of Andrology. - : Wiley. - 0105-6263 .- 1365-2605. ; 27:5, s. 282-290
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Abstract
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- An increasing incidence of testicular cancer has been reported from several western countries during the last decades. According to current hypothesis testicular cancer is initiated during the foetal period and exposure to endocrine disruptors such as some persistent organic pollutants has been of concern. We have previously reported the results for concentrations of polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB) and chlordanes in 58 cases with testicular cancer, 61 age-matched controls and 44 case mothers and 45 control mothers. In that report, significant increase of odds ratio (OR) was found for sum of PCBs, HCB, trans- and cis-nonachlordane in case mothers. These data have now been further analysed for 37 congeners of PCBs. No significant differences were found among cases and controls. However, case mothers had significantly increased concentrations of a number of PCB congeners. A priori decided grouping of PCBs yielded for oestrogenic PCBs OR = 2.4, 95% confidence interval (CI) = 0.95-6.0, enzyme-inducing PCBsOR = 2.6, 95% CI = 1.03-6.5 and toxic equivalents (TEQ) yielded OR = 3.3, 95% CI = 1.3-8.4. These data further elucidate the role of foetal exposure to different PCB congeners in the aetiology of testicular cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- polychlorinated biphenyls
- aetiology
- perinatal exposure
- testicular
- cancer
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hardell, L
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van Bavel, B
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Lindstrom, G
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Carlberg, M
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Eriksson, Mikael
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Dreifaldt, AC
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show more...
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Wijkstrom, H
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Starkhammar, Han ...
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Hallquist, A
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Kolmert, T
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Karolinska Institutet
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Linköping University