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Sökning: (WFRF:(Stokes Mark Andrew)) > (2006-2009) > Neuronal pentraxins...

Neuronal pentraxins mediate synaptic refinement in the developing visual system

Bjartmar, Lisa, 1966- (författare)
Cleveland Clinic Foundation
Huberman, Andrew (författare)
Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
Ullian, Erik (författare)
Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
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Rentería, René (författare)
8Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
Liu, Xiaoqin (författare)
Neurosciences Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Xu, Weifeng (författare)
Neurobiology and Psychiatry, Stanford University School of Medicine, Stanford, California 94305, USA
Prezioso, Jennifer (författare)
Neurosciences and 2Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Susman, Michael (författare)
Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
Stellwagen, David (författare)
Neurobiology and Psychiatry, Stanford University School of Medicine, Stanford, California 94305, USA
Stokes, Caleb (författare)
Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
Cho, Richard (författare)
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Worley, Paul (författare)
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Malenka, Robert (författare)
Neurobiology and Psychiatry, Stanford University School of Medicine, Stanford, California 94305, USA
Ball, Sherry (författare)
Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA/Research Service, Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
Peachey, Neal (författare)
Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA/Research Service, Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
Copenhagen, David (författare)
Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
Chapman, Barbara (författare)
Center for Neuroscience, University of California, Davis, California 95616, USA
Nakamoto, Masaru (författare)
Neurosciences Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Barres, Ben (författare)
Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
Perin, Mark (författare)
Neurosciences and 2Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
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 (creator_code:org_t)
2006
2006
Engelska.
Ingår i: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 26:23, s. 6269-6281
Relaterad länk:
http://urn.kb.se/res...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Neuronal pentraxins (NPs) define a family of proteins that are homologous to C-reactive and acute-phase proteins in the immune system and have been hypothesized to be involved in activity-dependent synaptic plasticity. To investigate the role of NPs in vivo, we generated mice that lack one, two, or all three NPs. NP1/2 knock-out mice exhibited defects in the segregation of eye-specific retinal ganglion cell (RGC) projections to the dorsal lateral geniculate nucleus, a process that involves activity-dependent synapse formation and elimination. Retinas from mice lacking NP1 and NP2 had cholinergically driven waves of activity that occurred at a frequency similar to that of wild-type mice, but several other parameters of retinal activity were altered. RGCs cultured from these mice exhibited a significant delay in functional maturation of glutamatergic synapses. Other developmental processes, such as pathfinding of RGCs at the optic chiasm and hippocampal long-term potentiation and long-term depression, appeared normal in NP-deficient mice. These data indicate that NPs are necessary for early synaptic refinements in the mammalian retina and dorsal lateral geniculate nucleus. We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS.

Nyckelord

retinogeniculate
neuronal pentraxins
synaptic plasticity
LTP
long-term potentiation
LTD
long-term depression
development
knock-out
retinal ganglion cell
MEDICINE
MEDICIN

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