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- Rudén, Christina
(författare)
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The use of mechanistic data and the handling of scientific uncertainty in carcinogen risk assessments - The trichloroethylene example
- 2002
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Ingår i: Regulatory toxicology and pharmacology. - : Elsevier BV. - 0273-2300 .- 1096-0295. ; 35:1, s. 80-94
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this paper is to explore how risk assessors actually use mechanistic data in carcinogen risk assessment and to discuss how the handling of scientific uncertainty may affect the outcome of the risk assessment. The analysis is performed by comparing 29 trichloroethylene risk assessment documents in general and 2 of these, namely the ECETOC (1994, Trichloroethylene: Assessment of Human Carcinogenic Hazard, Technical Report No. 60) and the OECD/EU (1996, Initial Assessment Report for the 4th SIAM (Screening Information Data Set Initial Assessment Meeting), May 1996: Trichloroethylene, sponsor country, United Kingdom [Draft]), in more detail. It is concluded that in this example the ECETOC required less evidence for considering a carcinogenic mechanism irrelevant to humans than did the OECD/EU risk assessors. There are examples of when two risk assessors have selected different primary data for their argumentation and also examples of how one and the same primary publication was interpreted differently. Biased data selection and evaluation of primary data that correlate to the risk assessor's overall conclusions have also been identified. The general comparison of all 29 TCE risk assessment documents indicates that the assessment of scientific uncertainty in the mechanistic data affects the overall conclusions.
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| 4. |
- Rios, Pilar, et al.
(författare)
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Aviles Canyon System : Increasing the benthic biodiversity knowledge
- 2022
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Ingår i: Estuarine, Coastal and Shelf Science. - : Elsevier. - 0272-7714 .- 1096-0015. ; 274
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Tidskriftsartikel (refereegranskat)abstract
- Macro and megafauna were studied in the Avile acute accent s Canyon System (ACS), southern Bay of Biscay (Cantabrian Sea), during several oceanographic cruises carried out from 2009 to 2017. The biodiversity of ACS is summarized and its description is herein updated after sampling surveys of several programmes (ECOMARG, INDEMARES, SponGES, INTEMARES) conducted by the Spanish Institute of Oceanography (IEO).This study has updated previous knowledge in the canyon area from past national and international projects, their reports and publications as well as data collected in the context of regional projects designed to gain new insight into the diversity of marine invertebrates and fishes from the ACS. Samples were taken using a range of sampling gears (Rock dredge, Beam trawl, Trawl gear GOC-73, Suprabenthic sledge, Box corer and Remoted operated vehicle), from 55 to 2291 m in depth. A total of 1015 species were identified at the ACS: 98 Porifera, 153 Cnidaria, 14 Brachiopoda, 22 Bryozoa, 97 Mollusca, 151 Annelida, 315 Arthropoda, 74 Echinodermata and 91 Chordata. New records for the Bay of Biscay fauna include 13 Porifera species, 17 Cnidaria, 7 Mollusca, Arthopoda, 3 Echinodermata and 4 Chordata. Also the bathymetric range of some species has been extended. As a result of the research projects carried out in the area in the last fifteen years, important information is now available which suggests that the ACS houses a large number of species with a high ecological value, that represents a biodiversity hotspot in terms of the presence of sponge aggregations and coral reefs in certain regions, and that it sustains important fisheries due to the abundance of comercial species. Given the relevance of the species and habitats occurring in the ACS, there is a need to implement a conservation and management plan of the area in order to maintain habitats in good state of preservation.
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| 5. |
- Lee, Paul Tae-Woo, et al.
(författare)
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Introduction: Applying Theory to Practice in Maritime Logistics
- 2016
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Ingår i: Dynamic shipping and port development in the globalized economy : Volume 1: Applying Theory to Practice in Maritime Logistics edited by Paul Tae-Woo Lee, Kevin Cullinane.. - Basingstoke : Palgrave-Macmillan. ; , s. 1-11
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Bokkapitel (refereegranskat)
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| 7. |
- O'Donovan, Tony, et al.
(författare)
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Detailed Diagnosis of Performance Anomalies in Sensornets
- 2010. - 9
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Konferensbidrag (refereegranskat)abstract
- We address the problem of analysing performance anomalies in sensor networks. In this paper, we propose an approach that uses the local flash storage of the motes for logging system data, in combination with online statistical analysis. Our results show not only that this is a feasible method but that the overhead is significantly lower than that of communication-centric methods, and that interesting patterns can be revealed when calculating the correlation of large data sets of separate event types.
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