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- Li, Yifei, et al.
(author)
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Can Nup88 expression be associated with atypical endometrial hyperplasia and endometrial cancer? A preliminary study
- 2016
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In: Pathology, Research and Practice. - : ELSEVIER GMBH, URBAN & FISCHER VERLAG. - 0344-0338 .- 1618-0631. ; 212:4, s. 274-278
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Journal article (peer-reviewed)abstract
- Background: Nup88 is overexpressed in a number of types of carcinomas and is associated with myometrial invasion, but its exact expression pattern in endometrial cancer and premalignant lesions is unknown. Aims: To evaluate the role of Nup88 in endometrial cancers and atypical endometrial hyperplasia and its clinicopathological significance. Methods: Nup88 expression was examined by immunohistochemistry in samples from 104 endometrial cancers, 21 atypical endometrial hyperplasia lesions, and 40 normal endometria. All samples were from patients who underwent surgery at the First Hospital of Hebei Medical University (Shijiazhuang, China) between April 2006 and December 2009. Nup88 expression was compared between the groups and associations were assessed between Nup88 and clinicopathological characteristics of the subjects. Results: Nup88 expression in cancer (76% of samples) and atypical hyperplasia (91%) was significantly higher compared to normal endometrium (33%, both P < 0.001), but there was no significant difference between endometrial cancer and atypical hyperplasia (P = 0.237). The expression of Nup88 increased significantly with increasing exposure time to estrogen (P = 0.033). Conclusions: Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions. Nup88 might be a useful biomarker for pre-malignant lesions and early-stage endometrial cancer. (C) 2016 Elsevier GmbH. All rights reserved.
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- Li, Yuhan, et al.
(author)
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Understanding the electrochemical properties of A(2)MSiO(4) (A = Li and Na; M = Fe, Mn, Co and Ni) and the Na doping effect on Li2MSiO4 from first-principles calculations
- 2016
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In: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 4:44, s. 17455-17463
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Journal article (peer-reviewed)abstract
- To explore the feasibility of regarding silicate materials as sustainable cathode materials for rechargeable Na ion batteries, the voltage plateaus, cycling stabilities, electrical conductivities and ionic conductivities of Li2MSiO4 and Na2MSiO4 (M = Fe, Mn, Co and Ni) are investigated by first principles calculations. The calculated electrochemical performance of silicate materials gives reasonable explanations for the poor capacity retention of Li2MnSiO4 as well as the reason why Li2FeSiO4 and Li2CoSiO4 exchange only one Li ion per formula unit. In comparison with Na2MSiO4, Li2MSiO4 presents higher voltage and better cycling stability. However, Na2MSiO4 displays higher electrical and ionic conductivities. Moreover, Na2NiSiO4 also presents significant potential for application as a good cathode material for Na ion batteries, as it can deliver high voltage and reversibly exchange 1.5 Li ions per formula unit. Furthermore, to make full use of the advantages of Li2MSiO4 and Na2MSiO4, a Na doped Li1.5Na0.5MSiO4 system is explored as well. The results suggest that Na doping can improve the electronic and ionic conductivities of Li2MSiO4 materials and simultaneously maintain the voltage and cycling stability. Therefore, Na ion doping should be an effective methodology to improve the performance of Li2MSiO4 cathode materials.
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- Bentham, James, et al.
(author)
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A century of trends in adult human height
- 2016
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In: eLIFE. - 2050-084X. ; 5
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Journal article (peer-reviewed)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 6. |
- Bentham, James, et al.
(author)
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A century of trends in adult human height
- 2016
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In: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Journal article (peer-reviewed)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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- Cheah, Charissa S. L., et al.
(author)
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Parenting hassles mediate predictors of Chinese and Korean immigrants' psychologically controlling parenting
- 2016
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In: Journal of applied developmental psychology. - : Elsevier. - 0193-3973 .- 1873-7900. ; 47, s. 13-22
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Journal article (peer-reviewed)abstract
- We examined: (1) the mediating role of parenting daily hassles in the associations between three predictors (child temperament, maternal psychological well-being, and marital quality) and psychologically controlling practices in two Asian immigrant samples. We also explored the moderating role of maternal acculturation in the path from parenting daily hassles to psychological control. Participants were 152 Chinese and 165 Korean immigrant mothers with preschool children in the U.S. Multi-group path analysis revealed that easier child temperament, higher psychological well-being, and better marital quality were each associated with fewer parenting daily hassles, which in turn were associated with less psychological control. These general mediating effects held for both groups. However, the indirect effects of child temperament, maternal psychological well-being, and marital quality through parenting daily hassles were further moderated by acculturation for Chinese immigrant mothers, but not Korean immigrant mothers. The culturally similar and different findings across the two groups were discussed.
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| 9. |
- Sun, Jing, et al.
(author)
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Distributed and hierarchical object-based image analysis for damage assessment : a case study of 2008 Wenchuan earthquake, China
- 2016
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In: Geomatics, Natural Hazards and Risk. - : Taylor & Francis. - 1947-5705 .- 1947-5713. ; , s. 1-11
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Journal article (peer-reviewed)abstract
- Object-based image analysis (OBIA) is an emerging technique for analyzing remote sensing image based on object properties including spectral, geometry, contextual and texture information. To reduce the computational cost of this comprehensive OBIA and make it more feasible in disaster responses, we developed a unique approach – distributed and hierarchical OBIA approach for damage assessment. This study demonstrated a completed classification of YingXiu town, heavily devastated by the 2008 Wenchuan earthquake using Quickbrid imagery. Two distinctive areas, mountainous areas and urban, were analyzed separately. This approach does not require substantial processing power and large amounts of available memory because image of a large disaster-affected area was split in smaller pieces. Two or more computers could be used in parallel to process and analyze these sub-images based on different requirements. The approach can be applicable in other cases whereas the established set of rules can be adopted in similar study areas. More experiments will be carried out in future studies to prove its feasibility.
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| 10. |
- Wang, Peng, et al.
(author)
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Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray
- 2016
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In: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 113:32, s. E4726-E4735
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Journal article (peer-reviewed)abstract
- The neuropeptide galanin coexists in rat brain with serotonin in the dorsal raphe nucleus and with noradrenaline in the locus coeruleus (LC), and it has been suggested to be involved in depression. We studied rats exposed to chronic mild stress (CMS), a rodent model of depression. As expected, these rats showed several endophenotypes relevant to depression-like behavior compared with controls. All these endophenotypes were normalized after administration of a selective serotonin reuptake inhibitor. The transcripts for galanin and two of its receptors, galanin receptor 1 (GALR1) and GALR2, were analyzed with quantitative real-time PCR using laser capture microdissection in the following brain regions: the hippocampal formation, LC, and ventral periaqueductal gray (vPAG). Only Galr1 mRNA levels were significantly increased, and only in the latter region. After knocking down Galr1 in the vPAG with an siRNA technique, all parameters of the depressive behavioral phenotype were similar to controls. Thus, the depression-like behavior in rats exposed to CMS is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects.
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