| 1. |
- Berntsson Svensson, Richard, 1978, et al.
(author)
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The unfulfilled potential of data-driven decision making in agile software development
- 2019
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In: Lecture Notes in Business Information Processing. - Cham : Springer International Publishing. - 1865-1356 .- 1865-1348. - 9783030190330 ; 355, s. 69-85
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Conference paper (peer-reviewed)abstract
- With the general trend towards data-driven decision making (DDDM), organizations are looking for ways to use DDDM to improve their decisions. However, few studies have looked into the practitioners view of DDDM, in particular for agile organizations. In this paper we investigated the experiences of using DDDM, and how data can improve decision making. An emailed questionnaire was sent out to 124 industry practitioners in agile software developing companies, of which 84 answered. The results show that few practitioners indicated a wide-spread use of DDDM in their current decision making practices. The practitioners were more positive to its future use for higher-level and more general decision making, fairly positive to its use for requirements elicitation and prioritization decisions, while being less positive to its future use at the team level. The practitioners do see a lot of potential for DDDM in an agile context; however, currently unfulfilled.
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| 2. |
- Alahyari, Hiva, 1979, et al.
(author)
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An exploratory study of waste in software development organizations using agile or lean approaches : A multiple case study at 14 organizations
- 2019
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In: Information and Software Technology. - : Elsevier B.V.. - 0950-5849 .- 1873-6025. ; 107, s. 78-94
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Journal article (peer-reviewed)abstract
- Context: The principal focus of lean is the identification and elimination of waste from the process with respect to maximizing customer value. Similarly, the purpose of agile is to maximize customer value and minimize unnecessary work and time delays. In both cases the concept of waste is important. Through an empirical study, we explore how waste is approached in agile software development organizations. Objective: This paper explores the concept of waste in agile/lean software development organizations and how it is defined, used, prioritized, reduced, or eliminated in practice Method: The data were collected using semi-structured open-interviews. 23 practitioners from 14 embedded software development organizations were interviewed representing two core roles in each organization. Results: Various wastes, categorized in 10 different categories, were identified by the respondents. From the mentioned wastes, not all were necessarily waste per se but could be symptoms caused by wastes. From the seven wastes of lean, Task-switching was ranked as the most important, and Extra-features, as the least important wastes according to the respondents’ opinion. However, most companies do not have their own or use an established definition of waste, more importantly, very few actively identify or try to eliminate waste in their organizations beyond local initiatives on project level. Conclusion: In order to identify, recognize and eliminate waste, a common understanding, and a joint and holistic view of the concept is needed. It is also important to optimize the whole organization and the whole product, as waste on one level can be important on another, thus sub-optimization should be avoided. Furthermore, to achieve a sustainable and effective waste handling, both the short-term and the long-term perspectives need to be considered. © 2018 Elsevier B.V.
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| 3. |
- Berntsson Svensson, Richard, 1978-, et al.
(author)
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BAM : backlog assessment method
- 2019
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In: Lecture Notes in Business Information Processing. - Cham : Springer Verlag. - 1865-1348. - 9783030190330 ; , s. 53-68
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Conference paper (peer-reviewed)abstract
- The necessity of software as stand-alone products, and as central parts of non-traditional software products have changed how software products are developed. It started with the introduction of the agile manifesto and has resulted in a change of how software process improvements (SPI) are conducted. Although there are agile SPI methods and several agile practices for evaluating and improving current processes and ways-of-working, no method or practices for evaluating the backlog exists. To address this gap, the Backlog Assessment Method (BAM) was developed and applied in collaboration with Telenor Sweden. BAM enables agile organizations to assess backlogs, and assure that the backlog items are good-enough for their needs and well aligned with the decision process. The results from the validation show that BAM is feasible and relevant in an industrial environment, and it indicates that BAM is useful as a tool to perform analysis of items in a specific backlog. © The Author(s) 2019.
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| 4. |
- Cadrin-Tourigny, Julia, et al.
(author)
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A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
- 2019
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In: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 40:23, s. 1850-1858
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Journal article (peer-reviewed)abstract
- AIMS: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. METHODS AND RESULTS: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44-9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73-0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92-0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.6% reduction of ICD placements with the same proportion of protected patients (P < 0.001). CONCLUSION: Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).
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| 6. |
- Joffrin, E., et al.
(author)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Research review (peer-reviewed)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 7. |
- Joshi, P., et al.
(author)
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Impact of usability on process lead-time in information systems: A case study
- 2019
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In: Journal of Systems and Software. - : Elsevier BV. - 0164-1212. ; 148, s. 148-169
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Journal article (peer-reviewed)abstract
- Technological advancements have started to demand the need for information systems to survive in the business world. There is an inherent need to be fast and efficient to conquer the market. In order to reduce time to market there is a need to shorten the lead-time in design and development process of products. Hence, lead-time is a significant performance metric for a product development organizations having information systems. It is important to explore the factors which affect the process lead-time in information systems. The objective of this study is to explore the impact that usability (one of the factors that may affect the process lead-time) has on process lead-time. This paper presents a case study involving qualitative and quantitate data from Volvo Group, which uses an information system called KOLA for their design and development process. Data was collected through 29 interviews, 17 think aloud sessions, 5 document studies, and 73 responses from a survey. This study identifies which usability factors and heuristics that have an impact on process lead-time. Moreover, the results show that the users level of experience determines the effective utilization of accelerators and thereby affecting the process lead-time. Finally, usability plays an important role in shortening the process lead-time in information systems. © 2018 Elsevier Inc.
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| 8. |
- Kulén, Martina, et al.
(author)
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Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
- 2019
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In: MedChemComm. - : Royal Society of Chemistry. - 2040-2503 .- 2040-2511. ; 10:11, s. 1966-1987
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Journal article (peer-reviewed)abstract
- Chlamydia trachomatis infections are a global health problem and new approaches to treat C. trachomatis with drugs of high specificity would be valuable. A library of substituted ring fused 2-pyridones has been synthesized and evaluated for their ability to attenuate C. trachomatis infectivity. In vivo pharmacokinetic studies were performed, with the best candidates demonstrating that a C8-methylsulfonamide substituent improved pharmacokinetic properties important for oral administration. C8-Methyl sulfonamide analogue 30 inhibited C. trachomatis infectivity in low micromolar concentrations. Further pharmacokinetic evaluation at an oral dose of 10 mg kg(-1) showed an apparent bioavailability of 41%, compared to C8-cyclopropyl and -methoxy analogues which had negligible oral uptake. In vitro ADME (absorption, distribution, metabolism and excretion) testing of solubility and Caco-2 cell permeability revealed that both solubility and permeability is greatly improved with the C8-methyl sulfonamide 30, effectively moving it from BCS (Biopharmaceutical Classification System) class IV to II.
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| 9. |
- Olsson, Annsofie
(curator, creator_code:cre_t)
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Forskarnas Galleri #7: Fighting cancer with plastic bullets
- 2019
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Artistic workabstract
- Cancer är en term som används för cirka 200 olika sjukdomar. Det de alla har gemensamt är att cellerna i kroppen börjar delas okontrollerat. 2018 fanns det 18 miljoner cancerfall över hela världen. I Sverige kommer ungefär varje tredje person att diagnostiseras med en cancersjukdom någon gång under sin livstid.Det är en stor utmaning för vetenskapen att hitta sätt att diagnostisera och behandla dessa sjukdomar. På Malmö universitet arbetar en ny generation kemister, fysiker och biologer tillsammans i två internationella nätverk, BioCapture och GlycoImaging. Deras forskning fokuserar på att utforma antikroppar, plastkulor, som ska upptäcka cancerceller i ett tidigt skede. Kulorna är dessutom billiga att producera.De två projekten samordnas av Börje Sellergren och Anette Gjörloff Wingren, som utbildar och handleder 19 doktorander. Utställningen Fighting Cancer with Plastic Bullets belyser doktorandernas tvärvetenskapliga arbete och deras betydelse för cancerforskningen. Biblioteket har fått bidrag av Sten K Johnsons stiftelse för att producera utställningen.
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| 10. |
- Ouriques, R. A. B., et al.
(author)
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Knowledge Management Strategies and Processes in Agile Software Development: A Systematic Literature Review
- 2019
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In: International Journal of Software Engineering and Knowledge Engineering. - : World Scientific Pub Co Pte Lt. - 0218-1940 .- 1793-6403. ; 29:3, s. 345-380
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Journal article (peer-reviewed)abstract
- Knowledge-intensive companies that adopt Agile Software Development (ASD) rely on efficient implementation of Knowledge Management (KM) strategies to promote different Knowledge Processes (KPs) to gain competitive advantage. This study aims to explore how companies that adopt ASD implement KM strategies utilizing practices that promote the KPs in the different organizational layers. Through a systematic literature review, we analyzed 32 primary studies, selected by automated search and snowballing in the extant literature. To analyze the data, we applied narrative synthesis. Most of the identified KM practices implement personalization strategies (81%), supported by codification (19%). Our review shows that the primary studies do not report KM practices in the strategic layer and two of them in the product portfolio layer; on the other hand, in the project layer, the studies report 33 practices that implement personalization strategy, and seven practices that implement codification. KM strategies in ASD promote mainly the knowledge transfer process with practices that stimulates social interaction to share tacit knowledge in the project layer. As a result of using informal communication, a significant amount of knowledge can be lost or not properly transferred to other individuals and, instead of propagating the knowledge, it remains inside a few individuals' minds.
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