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Genome-wide associa...
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
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- Williamson, Alice (author)
- University of Cambridge
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Norris, Dougall M (author)
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Yin, Xianyong (author)
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show more...
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Broadaway, K Alaine (author)
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Moxley, Anne H (author)
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Vadlamudi, Swarooparani (author)
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Wilson, Emma P (author)
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Jackson, Anne U (author)
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Ahuja, Vasudha (author)
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Andersen, Mette K (author)
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Arzumanyan, Zorayr (author)
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Bonnycastle, Lori L (author)
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Bornstein, Stefan R (author)
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Bretschneider, Maxi P (author)
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Buchanan, Thomas A (author)
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Chang, Yi-Cheng (author)
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Chuang, Lee-Ming (author)
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Chung, Ren-Hua (author)
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Clausen, Tine D (author)
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Damm, Peter (author)
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Delgado, Graciela E (author)
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de Mello, Vanessa D (author)
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Dupuis, Josée (author)
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Dwivedi, Om P (author)
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Erdos, Michael R (author)
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Silva, Lilian Fernandes (author)
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Frayling, Timothy M (author)
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Gieger, Christian (author)
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Goodarzi, Mark O (author)
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Guo, Xiuqing (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Klinisk epidemiologi
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Hakaste, Liisa (author)
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- Hammar, Ulf (author)
- Uppsala universitet,Molekylär epidemiologi
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- Hatem, G. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Herrmann, Sandra (author)
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Højlund, Kurt (author)
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Horn, Katrin (author)
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Hsueh, Willa A (author)
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Hung, Yi-Jen (author)
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Hwu, Chii-Min (author)
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Jonsson, Anna (author)
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Kårhus, Line L (author)
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Kleber, Marcus E (author)
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Kovacs, Peter (author)
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Lakka, Timo A (author)
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Lauzon, Marie (author)
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Lee, I-Te (author)
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Lindgren, Cecilia M (author)
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Lindström, Jaana (author)
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Linneberg, Allan (author)
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Liu, Ching-Ti (author)
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Luan, Jian'an (author)
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- Aly, D.M. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Mathiesen, Elisabeth (author)
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Moissl, Angela P (author)
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Morris, Andrew P (author)
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Narisu, Narisu (author)
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Perakakis, Nikolaos (author)
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Peters, Annette (author)
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- Prasad, R.B. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki
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Rodionov, Roman N (author)
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Roll, Kathryn (author)
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Rundsten, Carsten F (author)
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Sarnowski, Chloé (author)
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Savonen, Kai (author)
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Scholz, Markus (author)
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Sharma, Sapna (author)
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Stinson, Sara E (author)
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Suleman, Sufyan (author)
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Tan, Jingyi (author)
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Taylor, Kent D (author)
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Uusitupa, Matti (author)
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Vistisen, Dorte (author)
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Witte, Daniel R (author)
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Walther, Romy (author)
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Wu, Peitao (author)
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Xiang, Anny H (author)
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- Zethelius, Björn (author)
- Uppsala universitet,Geriatrik
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- Ahlqvist, E. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Bergman, Richard N (author)
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Chen, Yii-Der Ida (author)
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Collins, Francis S (author)
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- Fall, Tove, 1979- (author)
- Uppsala universitet,Molekylär epidemiologi
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Florez, Jose C (author)
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Fritsche, Andreas (author)
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Grallert, Harald (author)
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- Groop, L. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki
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Hansen, Torben (author)
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Koistinen, Heikki A (author)
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Komulainen, Pirjo (author)
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Laakso, Markku (author)
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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Loeffler, Markus (author)
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März, Winfried (author)
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- Meigs, James B (author)
- Lund University,University Hospital of Tubingen,Massachusetts General Hospital
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Raffel, Leslie J (author)
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Rauramaa, Rainer (author)
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Rotter, Jerome I (author)
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Schwarz, Peter E H (author)
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Stumvoll, Michael (author)
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Klinisk epidemiologi
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Tönjes, Anke (author)
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Tuomi, Tiinamaija (author)
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Tuomilehto, Jaakko (author)
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Wagner, Robert (author)
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Barroso, Inês (author)
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Walker, Mark (author)
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Grarup, Niels (author)
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Boehnke, Michael (author)
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Wareham, Nicholas J (author)
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Mohlke, Karen L (author)
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Wheeler, Eleanor (author)
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O'Rahilly, Stephen (author)
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Fazakerley, Daniel J (author)
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- Langenberg, Claudia (author)
- Queen Mary University,University of Cambridge,Berlin Institute of Health (BIH),Charité - University Medicine Berlin
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(creator_code:org_t)
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et al
- Springer Nature, 2023
- 2023
- English.
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In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Blood Glucose
- Diabetes Mellitus, Type 2
- Genome-Wide Association Study
- Glucose
- Humans
- Insulin
- Insulin Resistance
- glucose
- glucose transporter 4
- insulin
- adipocyte
- ancestry group
- Article
- body mass
- cell culture
- controlled study
- gene expression
- gene identification
- genetic variability
- genome-wide association study
- glucose transport
- human
- insulin level
- insulin resistance
- meta analysis (topic)
- non insulin dependent diabetes mellitus
- transcription regulation
- genetics
- glucose blood level
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Williamson, Alic ...
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Norris, Dougall ...
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Yin, Xianyong
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Broadaway, K Ala ...
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Moxley, Anne H
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Vadlamudi, Swaro ...
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show more...
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Wilson, Emma P
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Jackson, Anne U
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Ahuja, Vasudha
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Andersen, Mette ...
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Arzumanyan, Zora ...
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Bonnycastle, Lor ...
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Bornstein, Stefa ...
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Bretschneider, M ...
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Buchanan, Thomas ...
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Chang, Yi-Cheng
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Chuang, Lee-Ming
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Chung, Ren-Hua
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Clausen, Tine D
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Damm, Peter
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Delgado, Graciel ...
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de Mello, Vaness ...
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Dupuis, Josée
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Dwivedi, Om P
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Erdos, Michael R
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Silva, Lilian Fe ...
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Frayling, Timoth ...
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Gieger, Christia ...
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Goodarzi, Mark O
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Guo, Xiuqing
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Gustafsson, Stef ...
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Hakaste, Liisa
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Hammar, Ulf
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Hatem, G.
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Herrmann, Sandra
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Højlund, Kurt
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Horn, Katrin
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Hsueh, Willa A
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Hung, Yi-Jen
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Hwu, Chii-Min
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Jonsson, Anna
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Kårhus, Line L
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Kleber, Marcus E
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Kovacs, Peter
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Lakka, Timo A
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Lauzon, Marie
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Lee, I-Te
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Lindgren, Cecili ...
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Lindström, Jaana
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Linneberg, Allan
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Liu, Ching-Ti
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Luan, Jian'an
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Aly, D.M.
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Mathiesen, Elisa ...
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Moissl, Angela P
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Morris, Andrew P
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Narisu, Narisu
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Perakakis, Nikol ...
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Peters, Annette
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Prasad, R.B.
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Rodionov, Roman ...
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Roll, Kathryn
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Rundsten, Carste ...
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Sarnowski, Chloé
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Savonen, Kai
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Scholz, Markus
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Sharma, Sapna
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Stinson, Sara E
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Suleman, Sufyan
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Tan, Jingyi
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Taylor, Kent D
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Uusitupa, Matti
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Vistisen, Dorte
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Witte, Daniel R
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Walther, Romy
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Wu, Peitao
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Xiang, Anny H
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Zethelius, Björn
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Ahlqvist, E.
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Bergman, Richard ...
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Chen, Yii-Der Id ...
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Collins, Francis ...
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Fall, Tove, 1979 ...
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Florez, Jose C
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Fritsche, Andrea ...
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Grallert, Harald
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Groop, L.
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Hansen, Torben
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Koistinen, Heikk ...
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Komulainen, Pirj ...
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Laakso, Markku
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Lind, Lars
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Loeffler, Markus
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März, Winfried
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Meigs, James B
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Raffel, Leslie J
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Rauramaa, Rainer
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Rotter, Jerome I
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Schwarz, Peter E ...
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Stumvoll, Michae ...
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Sundström, Johan ...
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Tönjes, Anke
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Tuomi, Tiinamaij ...
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Tuomilehto, Jaak ...
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Wagner, Robert
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Barroso, Inês
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Walker, Mark
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Grarup, Niels
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Boehnke, Michael
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Wareham, Nichola ...
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Mohlke, Karen L
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Wheeler, Eleanor
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O'Rahilly, Steph ...
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Fazakerley, Dani ...
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Langenberg, Clau ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University