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Genome-wide associa...
Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci
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Tanskanen, T. (author)
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van den Berg, L. (author)
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Valimaki, N. (author)
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Aavikko, M. (author)
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- Ness-Jensen, E. (author)
- Karolinska Institutet
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Hveem, K. (author)
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- Wettergren, Yvonne, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Bexe-Lindskog, Elinor (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Tonisson, N. (author)
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Metspalu, A. (author)
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Silander, K. (author)
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Orlando, G. (author)
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Law, P. J. (author)
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Tuupanen, S. (author)
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Gylfe, A. E. (author)
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Hanninen, U. A. (author)
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Cajuso, T. (author)
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Kondelin, J. (author)
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Sarin, A. P. (author)
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Pukkala, E. (author)
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Jousilahti, P. (author)
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Salomaa, V. (author)
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Ripatti, S. (author)
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Palotie, A. (author)
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Jarvinen, H. (author)
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Renkonen-Sinisalo, L. (author)
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Lepisto, A. (author)
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Bohm, J. (author)
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Mecklin, J. P. (author)
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Al-Tassan, N. A. (author)
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Palles, C. (author)
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Martin, L. (author)
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Barclay, E. (author)
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Tenesa, A. (author)
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Farrington, S. M. (author)
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Timofeeva, M. N. (author)
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Meyer, B. F. (author)
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Wakil, S. M. (author)
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Campbell, H. (author)
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Smith, C. G. (author)
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Idziaszczyk, S. (author)
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Maughan, T. S. (author)
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Kaplan, R. (author)
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Kerr, R. (author)
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Kerr, D. (author)
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Buchanan, D. D. (author)
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Win, A. K. (author)
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Hopper, J. (author)
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Jenkins, M. A. (author)
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Newcomb, P. A. (author)
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Gallinger, S. (author)
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Conti, D. (author)
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Schumacher, F. R. (author)
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Casey, G. (author)
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Cheadle, J. P. (author)
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Dunlop, M. G. (author)
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Tomlinson, I. P. (author)
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Houlston, R. S. (author)
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Palin, K. (author)
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Aaltonen, L. A. (author)
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- ISSN 0020-7136
- 2017-10-12
- 2018
- English.
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In: International Journal of Cancer. - Stockholm : Wiley. - 0020-7136 .- 1097-0215. ; 142:3, s. 540-546
- Related links:
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https://onlinelibrar...
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http://hdl.handle.ne... (primary) (Object in context) (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://hdl.handle.ne...
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http://kipublication...
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Abstract
Subject headings
Close
- Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p=2.08 x 10(-4); OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p=1.50 x 10(-9); OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate<0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- colorectal cancer
- genetic predisposition to disease
- genome-wide association study
- single-
- susceptibility locus
- common variation
- chromosome 8q24
- colon-cancer
- mixed-model
- efficient
- scan
- imputation
- variants
- disease
- Oncology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Tanskanen, T.
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van den Berg, L.
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Valimaki, N.
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Aavikko, M.
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Ness-Jensen, E.
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Hveem, K.
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show more...
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Wettergren, Yvon ...
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Bexe-Lindskog, E ...
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Tonisson, N.
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Metspalu, A.
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Silander, K.
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Orlando, G.
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Law, P. J.
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Tuupanen, S.
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Gylfe, A. E.
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Hanninen, U. A.
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Cajuso, T.
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Kondelin, J.
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Sarin, A. P.
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Pukkala, E.
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Jousilahti, P.
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Salomaa, V.
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Ripatti, S.
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Palotie, A.
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Jarvinen, H.
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Renkonen-Sinisal ...
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Lepisto, A.
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Bohm, J.
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Mecklin, J. P.
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Al-Tassan, N. A.
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Palles, C.
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Martin, L.
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Barclay, E.
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Tenesa, A.
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Farrington, S. M ...
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Timofeeva, M. N.
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Meyer, B. F.
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Wakil, S. M.
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Campbell, H.
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Smith, C. G.
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Idziaszczyk, S.
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Maughan, T. S.
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Kaplan, R.
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Kerr, R.
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Kerr, D.
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Buchanan, D. D.
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Win, A. K.
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Hopper, J.
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Jenkins, M. A.
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Newcomb, P. A.
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Gallinger, S.
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Conti, D.
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Schumacher, F. R ...
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Casey, G.
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Cheadle, J. P.
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Dunlop, M. G.
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Tomlinson, I. P.
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Houlston, R. S.
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Palin, K.
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Aaltonen, L. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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Karolinska Institutet