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1.	Speliotes, Elizabeth K., et al. (author) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Journal article (peer-reviewed)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
2.	Scott, Robert A., et al. (author) Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways 2012 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:9, s. 991-1005 Journal article (peer-reviewed)abstract Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Salomaa, Veikko (2); Perola, Markus (2); Campbell, Harry (2); Rudan, Igor (2); Deloukas, Panos (2); North, Kari E. (2); show more...; Wareham, Nicholas J. (2); Kuusisto, Johanna (2); Laakso, Markku (2); McCarthy, Mark I (2); van Duijn, Cornelia ... (2); Boehnke, Michael (2); Mohlke, Karen L (2); Ingelsson, Erik (2); Ripatti, Samuli (2); Tuomilehto, Jaakko (2); Thorleifsson, Gudmar (2); Stefansson, Kari (2); Shuldiner, Alan R. (2); Mangino, Massimo (2); Willemsen, Gonneke (2); Gieger, Christian (2); Peters, Annette (2); Boomsma, Dorret I. (2); Kaprio, Jaakko (2); Jarvelin, Marjo-Riit ... (2); Barroso, Ines (2); Froguel, Philippe (2); Luan, Jian'an (2); Gustafsson, Stefan (2); Metspalu, Andres (2); Munroe, Patricia B. (2); Hicks, Andrew A. (2); Pramstaller, Peter P ... (2); Wright, Alan F. (2); Wilson, James F. (2); Kovacs, Peter (2); Rivadeneira, Fernand ... (2); Johnson, Toby (2); Harris, Tamara B (2); James, Alan L (2); Loos, Ruth J F (2); Hofman, Albert (2); Hui, Jennie (2); Smith, George Davey (2); Pouta, Anneli (2); Wild, Sarah H (2); Hayward, Caroline (2); Gudnason, Vilmundur (2); Polasek, Ozren (2); show less...

University: Uppsala University (2); Lund University (2); Karolinska Institutet (2); University of Gothenburg (1); Umeå University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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