Antibody response to dietary and autoantigens in G alpha i2-deficient mice.

• Mice with a targeted mutation in the G protein subunit G alpha i2 gene develop a colonic mucosal inflammation, with a highly activated B-cell response. We wanted to investigate whether this increased B-cell activity was directed against dietary antigens and/or various self tissues.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Animals

Autoantibodies

blood

metabolism

B-Lymphocytes

immunology

Colitis

etiology

immunology

Dietary Proteins

adverse effects

Enzyme-Linked Immunosorbent Assay

Female

GTP-Binding Protein alpha Subunit

Gi2

GTP-Binding Protein alpha Subunits

Gi-Go

deficiency

immunology

Humans

Intestinal Mucosa

immunology

Mice

Mice

SCID

Proto-Oncogene Proteins

deficiency

immunology

Rats

Rats

Sprague-Dawley

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)