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Convergent genetic ...
Convergent genetic and expression data implicate immunity in Alzheimer's disease
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Jones, Lesley (author)
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Lambert, Jean-Charles (author)
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Wang, Li-San (author)
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show more...
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Choi, Seung-Hoan (author)
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Harold, Denise (author)
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Vedernikov, Alexey (author)
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Escott-Price, Valentina (author)
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Stone, Timothy (author)
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Richards, Alexander (author)
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Bellenguez, Celine (author)
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Ibrahim-Verbaas, Carla A. (author)
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Naj, Adam C. (author)
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Sims, Rebecca (author)
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Gerrish, Amy (author)
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Jun, Gyungah (author)
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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Bis, Joshua C. (author)
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Beecham, Gary W. (author)
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Grenier-Boley, Benjamin (author)
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Russo, Giancarlo (author)
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Thornton-Wells, Tricia A. (author)
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Jones, Nicola (author)
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Smith, Albert V. (author)
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Chouraki, Vincent (author)
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Thomas, Charlene (author)
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Ikram, M. Arfan (author)
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Zelenika, Diana (author)
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Vardarajan, Badri N. (author)
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Kamatani, Yoichiro (author)
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Lin, Chiao-Feng (author)
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Schmidt, Helena (author)
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Kunkle, Brian W. (author)
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Dunstan, Melanie L. (author)
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Ruiz, Agustin (author)
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Bihoreau, Marie-Therese (author)
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Reitz, Christiane (author)
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Pasquier, Florence (author)
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Hollingworth, Paul (author)
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Hanon, Olivier (author)
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Fitzpatrick, Annette L. (author)
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Buxbaum, Joseph D. (author)
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Campion, Dominique (author)
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Crane, Paul K. (author)
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Becker, Tim (author)
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Gudnason, Vilmundur (author)
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- Cruchaga, Carlos (author)
- Karolinska Institutet
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Craig, David (author)
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Amin, Najaf (author)
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Berr, Claudine (author)
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Lopez, Oscar L. (author)
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De Jager, Philip L. (author)
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Deramecourt, Vincent (author)
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Johnston, Janet A. (author)
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Evans, Denis (author)
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Lovestone, Simon (author)
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- Letteneur, Luc (author)
- Karolinska Institutet
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Kornhuber, Johanes (author)
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Tarraga, Lluis (author)
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Rubinsztein, David C. (author)
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Eiriksdottir, Gudny (author)
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Sleegers, Kristel (author)
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Goate, Alison M. (author)
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Fievet, Nathalie (author)
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Huentelman, Matthew J. (author)
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Gill, Michael (author)
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Emilsson, Valur (author)
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Brown, Kristelle (author)
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Kamboh, M. Ilyas (author)
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- Keller, Lina (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Barberger-Gateau, Pascale (author)
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McGuinness, Bernadette (author)
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Larson, Eric B. (author)
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Myers, Amanda J. (author)
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Dufouil, Carole (author)
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Todd, Stephen (author)
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Wallon, David (author)
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Love, Seth (author)
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Kehoe, Pat (author)
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Rogaeva, Ekaterina (author)
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Gallacher, John (author)
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St George-Hyslop, Peter (author)
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Clarimon, Jordi (author)
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Lleo, Alberti (author)
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Bayer, Anthony (author)
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Tsuang, Debby W. (author)
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Yu, Lei (author)
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Tsolaki, Magda (author)
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Bossu, Paola (author)
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Spalletta, Gianfranco (author)
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Proitsi, Petra (author)
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Collinge, John (author)
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Sorbi, Sandro (author)
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Garcia, Fiorentino Sanchez (author)
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Fox, Nick (author)
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Hardy, John (author)
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Deniz Naranjo, Maria Candida (author)
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Razquin, Cristina (author)
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Bosco, Paola (author)
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Clarke, Robert (author)
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Brayne, Carol (author)
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Galimberti, Daniela (author)
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Mancuso, Michelangelo (author)
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Moebus, Susanne (author)
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Mecocci, Patrizia (author)
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del Zompo, Maria (author)
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Maier, Wolfgang (author)
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Hampel, Harald (author)
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Pilotto, Alberto (author)
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Bullido, Maria (author)
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Panza, Francesco (author)
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Caffarra, Paolo (author)
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Nacmias, Benedetta (author)
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Gilbert, John R. (author)
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Mayhaus, Manuel (author)
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Jessen, Frank (author)
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Dichgans, Martin (author)
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Lannfelt, Lars (author)
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Hakonarson, Hakon (author)
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Pichler, Sabrina (author)
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Carrasquillo, Minerva M. (author)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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Beekly, Duane (author)
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Alavarez, Victoria (author)
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Zou, Fanggeng (author)
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Valladares, Otto (author)
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Younkin, Steven G. (author)
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Coto, Eliecer (author)
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Hamilton-Nelson, Kara L. (author)
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Mateo, Ignacio (author)
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Owen, Michael J. (author)
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Faber, Kelley M. (author)
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Jonsson, Palmi V. (author)
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Combarros, Onofre (author)
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O'Donovan, Michael C. (author)
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Cantwell, Laura B. (author)
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Soininen, Hilkka (author)
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Blacker, Deborah (author)
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Mead, Simon (author)
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Mosley, Thomas H. (author)
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Bennett, David A. (author)
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Harris, Tamara B. (author)
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- Fratiglioni, Laura (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska University Hospital, Sweden
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Holmes, Clive (author)
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de Bruijn, Renee F. A. G. (author)
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Passmore, Peter (author)
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Montine, Thomas J. (author)
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Bettens, Karolien (author)
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Rotter, Jerome I. (author)
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Brice, Alexis (author)
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Morgan, Kevin (author)
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Foroud, Tatiana M. (author)
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Kukull, Walter A. (author)
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Hannequin, Didier (author)
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Powell, John F. (author)
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Nails, Michael A. (author)
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Ritchie, Karen (author)
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Lunetta, Kathryn L. (author)
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Kauwe, John S. K. (author)
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Boerwinkle, Eric (author)
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Riemenschneider, Matthias (author)
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Boada, Merce (author)
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Hiltunen, Mikko (author)
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Martin, Eden R. (author)
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Pastor, Pau (author)
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Schmidt, Reinhold (author)
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Rujescu, Dan (author)
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Dartigues, Jean-Francois (author)
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Mayeux, Richard (author)
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Tzourio, Christophe (author)
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Hofman, Albert (author)
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Noethen, Markus M. (author)
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Graff, Caroline (author)
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Psaty, Bruce M. (author)
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Haines, Jonathan L. (author)
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Lathrop, Mark (author)
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Pericak-Vance, Margaret A. (author)
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Launer, Lenore J. (author)
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Farrer, Lindsay A. (author)
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van Duijn, Cornelia M. (author)
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Van Broeckhoven, Christine (author)
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Ramirez, Alfredo (author)
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Schellenberg, Gerard D. (author)
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Seshadri, Sudha (author)
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Amouyel, Philippe (author)
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Williams, Julie (author)
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Holmans, Peter A. (author)
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(creator_code:org_t)
- 2014-12-19
- 2015
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:6, s. 658-671
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. Methods: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results: ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 X 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 X 10(-11)), cholesterol transport (P = 2.96 X 10(-9)), and proteasome-ubiquitin activity (P = 1.34 X 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). Conclusions: The immime response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Dementia
- Neurodegeneration
- Immune response
- Endocytosis
- Cholesterol metabolism
- Ubiquitination
- Pathway analysis
- ALIGATOR
- Weighted gene co-expression network analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Jones, Lesley
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Lambert, Jean-Ch ...
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Wang, Li-San
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Choi, Seung-Hoan
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Harold, Denise
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Vedernikov, Alex ...
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show more...
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Escott-Price, Va ...
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Stone, Timothy
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Richards, Alexan ...
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Bellenguez, Celi ...
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Ibrahim-Verbaas, ...
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Naj, Adam C.
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Sims, Rebecca
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Gerrish, Amy
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Jun, Gyungah
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Lannfelt, Lars
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Bis, Joshua C.
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Beecham, Gary W.
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Grenier-Boley, B ...
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Russo, Giancarlo
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Thornton-Wells, ...
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Jones, Nicola
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Smith, Albert V.
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Chouraki, Vincen ...
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Thomas, Charlene
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Ikram, M. Arfan
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Zelenika, Diana
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Vardarajan, Badr ...
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Kamatani, Yoichi ...
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Lin, Chiao-Feng
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Schmidt, Helena
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Kunkle, Brian W.
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Dunstan, Melanie ...
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Ruiz, Agustin
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Bihoreau, Marie- ...
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Reitz, Christian ...
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Pasquier, Floren ...
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Hollingworth, Pa ...
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Hanon, Olivier
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Fitzpatrick, Ann ...
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Buxbaum, Joseph ...
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Campion, Dominiq ...
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Crane, Paul K.
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Becker, Tim
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Gudnason, Vilmun ...
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Cruchaga, Carlos
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Craig, David
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Amin, Najaf
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Berr, Claudine
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Lopez, Oscar L.
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De Jager, Philip ...
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Deramecourt, Vin ...
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Johnston, Janet ...
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Evans, Denis
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Lovestone, Simon
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Letteneur, Luc
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Kornhuber, Johan ...
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Tarraga, Lluis
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Rubinsztein, Dav ...
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Eiriksdottir, Gu ...
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Sleegers, Kriste ...
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Goate, Alison M.
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Fievet, Nathalie
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Huentelman, Matt ...
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Gill, Michael
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Emilsson, Valur
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Brown, Kristelle
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Kamboh, M. Ilyas
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Keller, Lina
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Barberger-Gateau ...
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McGuinness, Bern ...
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Larson, Eric B.
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Myers, Amanda J.
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Dufouil, Carole
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Todd, Stephen
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Wallon, David
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Love, Seth
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Kehoe, Pat
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Rogaeva, Ekateri ...
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Gallacher, John
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St George-Hyslop ...
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Clarimon, Jordi
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Lleo, Alberti
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Bayer, Anthony
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Tsuang, Debby W.
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Yu, Lei
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Tsolaki, Magda
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Bossu, Paola
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Spalletta, Gianf ...
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Proitsi, Petra
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Collinge, John
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Sorbi, Sandro
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Garcia, Fiorenti ...
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Fox, Nick
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Hardy, John
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Deniz Naranjo, M ...
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Razquin, Cristin ...
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Bosco, Paola
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Clarke, Robert
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Brayne, Carol
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Galimberti, Dani ...
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Mancuso, Michela ...
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Moebus, Susanne
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Mecocci, Patrizi ...
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del Zompo, Maria
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Maier, Wolfgang
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Hampel, Harald
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Pilotto, Alberto
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Bullido, Maria
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Panza, Francesco
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Caffarra, Paolo
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Nacmias, Benedet ...
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Gilbert, John R.
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Mayhaus, Manuel
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Jessen, Frank
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Dichgans, Martin
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Hakonarson, Hako ...
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Pichler, Sabrina
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Carrasquillo, Mi ...
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Ingelsson, Marti ...
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Beekly, Duane
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Alavarez, Victor ...
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Zou, Fanggeng
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Valladares, Otto
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Younkin, Steven ...
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Coto, Eliecer
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Hamilton-Nelson, ...
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Mateo, Ignacio
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Owen, Michael J.
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Faber, Kelley M.
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Jonsson, Palmi V ...
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Combarros, Onofr ...
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O'Donovan, Micha ...
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Cantwell, Laura ...
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Soininen, Hilkka
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Blacker, Deborah
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Mead, Simon
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Mosley, Thomas H ...
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Bennett, David A ...
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Harris, Tamara B ...
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Fratiglioni, Lau ...
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Holmes, Clive
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de Bruijn, Renee ...
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Passmore, Peter
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Montine, Thomas ...
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Bettens, Karolie ...
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Rotter, Jerome I ...
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Brice, Alexis
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Morgan, Kevin
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Foroud, Tatiana ...
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Kukull, Walter A ...
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Hannequin, Didie ...
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Powell, John F.
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Nails, Michael A ...
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Ritchie, Karen
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Lunetta, Kathryn ...
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Kauwe, John S. K ...
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Boerwinkle, Eric
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Riemenschneider, ...
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Boada, Merce
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Hiltunen, Mikko
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Martin, Eden R.
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Pastor, Pau
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Schmidt, Reinhol ...
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Rujescu, Dan
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Dartigues, Jean- ...
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Mayeux, Richard
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Tzourio, Christo ...
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Hofman, Albert
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Noethen, Markus ...
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Graff, Caroline
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Psaty, Bruce M.
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Haines, Jonathan ...
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Lathrop, Mark
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Pericak-Vance, M ...
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Launer, Lenore J ...
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Farrer, Lindsay ...
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van Duijn, Corne ...
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Van Broeckhoven, ...
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Ramirez, Alfredo
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Schellenberg, Ge ...
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Seshadri, Sudha
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Amouyel, Philipp ...
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Williams, Julie
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Holmans, Peter A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Stockholm University
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Karolinska Institutet
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Uppsala University