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A common variant at...
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
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Haiman, Christopher A. (author)
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Chen, Gary K. (author)
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Vachon, Celine M. (author)
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show more...
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Canzian, Federico (author)
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Dunning, Alison (author)
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Millikan, Robert C. (author)
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Wang, Xianshu (author)
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Ademuyiwa, Foluso (author)
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Ahmed, Shahana (author)
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Ambrosone, Christine B. (author)
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Baglietto, Laura (author)
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Balleine, Rosemary (author)
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Bandera, Elisa V. (author)
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Beckmann, Matthias W. (author)
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Berg, Christine D. (author)
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Bernstein, Leslie (author)
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Blomqvist, Carl (author)
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Blot, William J. (author)
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Brauch, Hiltrud (author)
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Buring, Julie E. (author)
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Carey, Lisa A. (author)
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Carpenter, Jane E. (author)
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Chang-Claude, Jenny (author)
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Chanock, Stephen J. (author)
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Chasman, Daniel I. (author)
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Clarke, Christine L. (author)
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Cox, Angela (author)
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Cross, Simon S. (author)
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Deming, Sandra L. (author)
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Diasio, Robert B. (author)
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Dimopoulos, Athanasios M. (author)
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Driver, W. Ryan (author)
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Duennebier, Thomas (author)
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Durcan, Lorraine (author)
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Eccles, Diana (author)
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Edlund, Christopher K. (author)
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Ekici, Arif B. (author)
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Fasching, Peter A. (author)
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Feigelson, Heather S. (author)
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Flesch-Janys, Dieter (author)
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Fostira, Florentia (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Fountzilas, George (author)
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- Gerty, Susan M. (author)
- Karolinska Institutet
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Giles, Graham G. (author)
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Godwin, Andrew K. (author)
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Goodfellow, Paul (author)
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Graham, Nikki (author)
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Greco, Dario (author)
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Hamann, Ute (author)
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Hankinson, Susan E. (author)
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Hartmann, Arndt (author)
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Hein, Rebecca (author)
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Heinz, Judith (author)
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Holbrook, Andrea (author)
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Hoover, Robert N. (author)
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Hu, Jennifer J. (author)
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Hunter, David J. (author)
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Ingles, Sue A. (author)
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Irwanto, Astrid (author)
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Ivanovich, Jennifer (author)
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John, Esther M. (author)
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Johnson, Nicola (author)
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Jukkola-Vuorinen, Arja (author)
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Kaaks, Rudolf (author)
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Ko, Yon-Dschun (author)
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Kolonel, Laurence N. (author)
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Konstantopoulou, Irene (author)
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Kosma, Veli-Matti (author)
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Kulkarni, Swati (author)
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Lambrechts, Diether (author)
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Lee, Adam M. (author)
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Le Marchand, Loic (author)
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Lesnick, Timothy (author)
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Liu, Jianjun (author)
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Lindstrom, Sara (author)
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Mannermaa, Arto (author)
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Margolin, Sara (author)
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Martin, Nicholas G. (author)
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Miron, Penelope (author)
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Montgomery, Grant W. (author)
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Nevanlinna, Heli (author)
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Nickels, Stephan (author)
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Nyante, Sarah (author)
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Olswold, Curtis (author)
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Palmer, Julie (author)
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Pathak, Harsh (author)
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Pectasides, Dimitrios (author)
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Perou, Charles M. (author)
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Peto, Julian (author)
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Pharoah, Paul D. P. (author)
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Pooler, Loreall C. (author)
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Press, Michael F. (author)
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Pylkas, Katri (author)
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Rebbeck, Timothy R. (author)
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Rodriguez-Gil, Jorge L. (author)
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Rosenberg, Lynn (author)
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Ross, Eric (author)
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Ruediger, Thomas (author)
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Silva, Isabel dos Santos (author)
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Sawyer, Elinor (author)
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Schmidt, Marjanka K. (author)
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Schulz-Wendtland, Ruediger (author)
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Schumacher, Fredrick (author)
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Severi, Gianluca (author)
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Sheng, Xin (author)
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Signorello, Lisa B. (author)
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Sinn, Hans-Peter (author)
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Stevens, Kristen N. (author)
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Southey, Melissa C. (author)
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Tapper, William J. (author)
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Tomlinson, Ian (author)
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Hogervorst, Frans B. L. (author)
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Wauters, Els (author)
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Weaver, JoEllen (author)
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Wildiers, Hans (author)
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Winqvist, Robert (author)
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Van Den Berg, David (author)
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Wan, Peggy (author)
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Xia, Lucy Y. (author)
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Yannoukakos, Drakoulis (author)
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Zheng, Wei (author)
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Ziegler, Regina G. (author)
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Siddiq, Afshan (author)
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Slager, Susan L. (author)
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Stram, Daniel O. (author)
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Easton, Douglas (author)
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Kraft, Peter (author)
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Henderson, Brian E. (author)
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Couch, Fergus J. (author)
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(creator_code:org_t)
- 2011-10-30
- 2011
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
- Related links:
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http://dx.doi.org/10...
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https://cdr.lib.unc....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- ref (subject category)
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Haiman, Christop ...
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Chen, Gary K.
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Vachon, Celine M ...
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Canzian, Federic ...
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Dunning, Alison
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Millikan, Robert ...
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show more...
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Wang, Xianshu
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Ademuyiwa, Folus ...
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Ahmed, Shahana
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Ambrosone, Chris ...
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Baglietto, Laura
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Balleine, Rosema ...
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Bandera, Elisa V ...
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Beckmann, Matthi ...
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Berg, Christine ...
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Bernstein, Lesli ...
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Blomqvist, Carl
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Blot, William J.
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Brauch, Hiltrud
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Buring, Julie E.
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Carey, Lisa A.
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Carpenter, Jane ...
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Chang-Claude, Je ...
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Chanock, Stephen ...
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Chasman, Daniel ...
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Clarke, Christin ...
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Cox, Angela
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Cross, Simon S.
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Deming, Sandra L ...
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Diasio, Robert B ...
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Dimopoulos, Atha ...
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Driver, W. Ryan
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Duennebier, Thom ...
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Durcan, Lorraine
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Eccles, Diana
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Edlund, Christop ...
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Ekici, Arif B.
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Fasching, Peter ...
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Feigelson, Heath ...
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Flesch-Janys, Di ...
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Fostira, Florent ...
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Försti, Asta
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Fountzilas, Geor ...
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Gerty, Susan M.
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Giles, Graham G.
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Godwin, Andrew K ...
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Goodfellow, Paul
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Graham, Nikki
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Greco, Dario
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Hamann, Ute
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Hankinson, Susan ...
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Hartmann, Arndt
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Hein, Rebecca
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Heinz, Judith
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Holbrook, Andrea
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Hoover, Robert N ...
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Hu, Jennifer J.
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Hunter, David J.
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Ingles, Sue A.
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Irwanto, Astrid
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Ivanovich, Jenni ...
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John, Esther M.
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Johnson, Nicola
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Jukkola-Vuorinen ...
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Kaaks, Rudolf
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Ko, Yon-Dschun
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Kolonel, Laurenc ...
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Konstantopoulou, ...
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Kosma, Veli-Matt ...
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Kulkarni, Swati
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Lambrechts, Diet ...
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Lee, Adam M.
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Le Marchand, Loi ...
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Lesnick, Timothy
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Liu, Jianjun
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Lindstrom, Sara
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Mannermaa, Arto
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Margolin, Sara
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Martin, Nicholas ...
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Miron, Penelope
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Montgomery, Gran ...
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Nevanlinna, Heli
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Nickels, Stephan
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Nyante, Sarah
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Olswold, Curtis
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Palmer, Julie
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Pathak, Harsh
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Pectasides, Dimi ...
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Perou, Charles M ...
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Peto, Julian
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Pharoah, Paul D. ...
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Pooler, Loreall ...
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Press, Michael F ...
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Pylkas, Katri
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Rebbeck, Timothy ...
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Rodriguez-Gil, J ...
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Rosenberg, Lynn
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Ross, Eric
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Ruediger, Thomas
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Silva, Isabel do ...
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Sawyer, Elinor
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Schmidt, Marjank ...
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Schulz-Wendtland ...
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Schumacher, Fred ...
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Severi, Gianluca
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Sheng, Xin
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Signorello, Lisa ...
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Sinn, Hans-Peter
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Stevens, Kristen ...
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Southey, Melissa ...
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Tapper, William ...
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Tomlinson, Ian
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Hogervorst, Fran ...
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Wauters, Els
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Weaver, JoEllen
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Wildiers, Hans
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Winqvist, Robert
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Van Den Berg, Da ...
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Wan, Peggy
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Xia, Lucy Y.
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Yannoukakos, Dra ...
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Zheng, Wei
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Ziegler, Regina ...
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Siddiq, Afshan
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Slager, Susan L.
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Stram, Daniel O.
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Easton, Douglas
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Kraft, Peter
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Henderson, Brian ...
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Couch, Fergus J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Nature Genetics
- By the university
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Lund University
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Karolinska Institutet