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Diabetes and risk o...
Diabetes and risk of pancreatic cancer : a pooled analysis from the pancreatic cancer cohort consortium
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Elena, J. W. (author)
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Steplowski, E. (author)
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Yu, K. (author)
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show more...
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Hartge, P. (author)
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Tobias, G. S. (author)
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Brotzman, M. J. (author)
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Chanock, S. J. (author)
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Stolzenberg-Solomon, R. Z. (author)
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Arslan, A. A. (author)
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Bueno-De-Mesquita, H. B. (author)
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Helzlsouer, K. (author)
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Jacobs, E. J. (author)
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Lacroix, A. (author)
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Petersen, G. (author)
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Zheng, W. (author)
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Albanes, D. (author)
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Allen, N. E. (author)
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Amundadottir, L. (author)
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Bao, Y. (author)
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Boeing, H. (author)
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Boutron-Ruault, M. -C (author)
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Buring, J. E. (author)
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Gaziano, J. M. (author)
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Giovannucci, E. L. (author)
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Duell, E. J. (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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Howard, B. V. (author)
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Hunter, D. J. (author)
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Hutchinson, A. (author)
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Jacobs, K. B. (author)
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Kooperberg, C. (author)
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Kraft, P. (author)
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Mendelsohn, J. B. (author)
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Michaud, D. S. (author)
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Palli, D. (author)
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Phillips, L. S. (author)
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Overvad, K. (author)
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Patel, A. V. (author)
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Sansbury, L. (author)
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Shu, X. -O (author)
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Simon, M. S. (author)
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Slimani, N. (author)
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Trichopoulos, D. (author)
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Visvanathan, K. (author)
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Virtamo, J. (author)
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Wolpin, B. M. (author)
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Zeleniuch-Jacquotte, A. (author)
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Fuchs, C. S. (author)
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Hoover, R. N. (author)
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Gross, M. (author)
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show less...
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(creator_code:org_t)
- 2012-10-31
- 2013
- English.
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In: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 24:1, s. 13-25
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cohort consortium
- Diabetes
- Pancreatic cancer
- Risk factor
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Elena, J. W.
-
Steplowski, E.
-
Yu, K.
-
Hartge, P.
-
Tobias, G. S.
-
Brotzman, M. J.
-
show more...
-
Chanock, S. J.
-
Stolzenberg-Solo ...
-
Arslan, A. A.
-
Bueno-De-Mesquit ...
-
Helzlsouer, K.
-
Jacobs, E. J.
-
Lacroix, A.
-
Petersen, G.
-
Zheng, W.
-
Albanes, D.
-
Allen, N. E.
-
Amundadottir, L.
-
Bao, Y.
-
Boeing, H.
-
Boutron-Ruault, ...
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Buring, J. E.
-
Gaziano, J. M.
-
Giovannucci, E. ...
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Duell, E. J.
-
Hallmans, Göran
-
Howard, B. V.
-
Hunter, D. J.
-
Hutchinson, A.
-
Jacobs, K. B.
-
Kooperberg, C.
-
Kraft, P.
-
Mendelsohn, J. B ...
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Michaud, D. S.
-
Palli, D.
-
Phillips, L. S.
-
Overvad, K.
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Patel, A. V.
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Sansbury, L.
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Shu, X. -O
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Simon, M. S.
-
Slimani, N.
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Trichopoulos, D.
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Visvanathan, K.
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Virtamo, J.
-
Wolpin, B. M.
-
Zeleniuch-Jacquo ...
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Fuchs, C. S.
-
Hoover, R. N.
-
Gross, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Causes an ...
- By the university
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Umeå University