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Surgical Morbidity ...
Surgical Morbidity and Mortality From the Multicenter Randomized Controlled NeoRes II Trial : Standard Versus Prolonged Time to Surgery After Neoadjuvant Chemoradiotherapy for Esophageal Cancer.
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- Nilsson, Klara (författare)
- Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Division of Surgery, Karolinska Institute, Stockholm, Sweden,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Klevebro, Fredrik (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Rouvelas, Ioannis (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Lindblad, Mats (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Szabo, Eva, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery, Faculty of Medicine and Health, Örebro University, Sweden,Orebro Univ, Sweden
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- Halldestam, Ingvar (författare)
- Department of Surgery, University Hospital of Linköping, Linköping, Sweden,Region Östergötland, Kirurgiska kliniken US
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- Smedh, Ulrika (författare)
- Department of Surgery, Sahlgrenska University Hospital, Gothenburg Sweden,Sahlgrens Univ Hosp, Sweden
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- Wallner, Bengt, 1962- (författare)
- Umeå universitet,Kirurgi,Department of Surgical and Perioperative Sciences, Umeå University Hospital, Umeå, Sweden,Umea Univ Hosp, Sweden
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- Johansson, Jan (författare)
- Department of Surgery, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Sweden
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- Johnsen, Gjermund (författare)
- Department of Gastrointestinal Surgery, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway,Trondheim Reg & Univ Hosp, Norway
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- Aahlin, Eirik Kjus (författare)
- Department of GI and HPB Surgery, University Hospital of Northern Norway, Tromsø, Norway,Univ Hosp Northern Norway, Norway
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- Johannessen, Hans-Olaf (författare)
- Department of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
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- Hjortland, Geir Olav (författare)
- Department of Oncology, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
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- Bartella, Isabel (författare)
- Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany,Univ Cologne, Germany
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- Schröder, Wolfgang (författare)
- Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany,Univ Cologne, Germany
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- Bruns, Christiane (författare)
- Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany,Univ Cologne, Germany
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- Nilsson, Magnus (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2020
- 2020
- Engelska.
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Ingår i: Annals of Surgery. - : Lippincott Williams & Wilkins. - 0003-4932 .- 1528-1140. ; 272:5, s. 684-689
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To investigate if prolonged TTS after completed nCRT improves postoperative outcomes for esophageal and esophagogastric junction cancer.SUMMARY OF BACKGROUND DATA: TTS has traditionally been 4-6 weeks after completed nCRT. However, the optimal timing is not known.METHODS: A multicenter clinical trial was performed with randomized allocation of TTS of 4-6 or 10-12 weeks. The primary endpoint of this sub-study was overall postoperative complications defined as Clavien-Dindo grade II-V. Secondary endpoints included complication severity according to Clavien-Dindo grade IIIb-V, postoperative 90-day mortality, and length of hospital stay. The study was registered in Clinicaltrials.gov (NCT02415101).RESULTS: In total 249 patients were randomized. There were no significant differences between standard TTS and prolonged TTS with regard to overall incidence of complications Clavien-Dindo grade II-V (63.2% vs 72.6%, P = 0.134) or regarding Clavien-Dindo grade IIIb-V complications (31.6% vs 34.9%, P = 0.603). There were no statistically significant differences between standard and prolonged TTS regarding anastomotic leak (P = 0.596), conduit necrosis (P = 0.524), chyle leak (P = 0.427), pneumonia (P = 0.548), and respiratory failure (P = 0.723). In the standard TTS arm 5 patients (4.3%) died within 90 days of surgery, compared to 4 patients (3.8%) in the prolonged TTS arm (P = 1.0). Median length of hospital stay was 15 days in the standard TTS arm and 17 days in the prolonged TTS arm (P = 0.234).CONCLUSION: The timing of surgery after completed nCRT for carcinoma of the esophagus or esophagogastric junction, is not of major importance with regard to short-term postoperative outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- esophageal cancer
- esophageal carcinoma
- esophagectomy
- esophagogastric cancer
- neoadjuvant chemoradiotherapy
- neoadjuvant treatment
- postoperative morbidity
- postoperative mortality
- surgical resection
- time to surgery
- timing of surgery
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- Av författaren/redakt...
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Nilsson, Klara
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Klevebro, Fredri ...
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Rouvelas, Ioanni ...
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Lindblad, Mats
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Szabo, Eva, 1973 ...
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Halldestam, Ingv ...
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visa fler...
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Smedh, Ulrika
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Wallner, Bengt, ...
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Johansson, Jan
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Johnsen, Gjermun ...
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Aahlin, Eirik Kj ...
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Johannessen, Han ...
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Hjortland, Geir ...
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Bartella, Isabel
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Schröder, Wolfga ...
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Bruns, Christian ...
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Nilsson, Magnus
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Annals of Surger ...
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Karolinska Institutet
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Linköpings universitet