| 1. |
- Fryzek, J.P., et al.
(author)
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Characteristics of women with cosmetic breast augmentation surgery compared with breast reduction surgery patients and women in the general population of Sweden
- 2000
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In: Annals of Plastic Surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0148-7043 .- 1536-3708. ; 45:4, s. 349-356
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Journal article (peer-reviewed)abstract
- To determine whether women with cosmetic breast implants have distinct demographic, lifestyle, and reproductive characteristics that put them at increased risk for subsequent morbidity, the authors compared 1,369 such women to 2,211 women who had undergone breast reduction surgery, and to a random sample of 49,262 women from the general population of Sweden. Information was collected through self-administered questionnaires, and comparisons were made using the prevalence odds ratio. Women with cosmetic breast implants were significantly (p <0.05) more likely to be current smokers, have a lower body mass index, have had a prematurely terminated pregnancy (induced abortion or miscarriage), and have had fewer live births than either women who underwent breast reduction or women from the general population. Type of implant (silicone gel or saline) did not modify the associations. Regardless of the comparison group used, studies of the health effects of breast implants need to consider that women who undergo cosmetic breast implantation have certain distinct characteristics.
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| 2. |
- Glynn, Anders, et al.
(author)
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Regionala skillnader i kvinnors kroppsbelastning av persistenta organiskamiljöföroreningar
- 2000
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Reports (other academic/artistic)abstract
- Serumhalter av PCB och klorerade bekämpningsmedel studerades bland 205 äldre kvinnorfrån 12 län efter syd- och ostkusten samt runt Vänern och Vättern. Syftet var att undersöka omdet finns regionala skillnader i kroppsbelastning av PCB och klorerade bekämpningsmedelbland äldre kvinnor i Sverige. Tio PCB-föreningar (IUPAC nr 28, 52, 101, 105, 118, 138,153, 156, 167 och 180) och 10 föreningar härrörande från klorerade bekämpningsmedelanalyserades (p,p'-DDT, o,p'-DDT, p,p'-DDE, p,p'-DDD, HCB, -HCH, -HCH, -HCH,trans-nonaklor och oxyklordan). I den statistiska analysen delades de 12 länen in i fyraregioner, Malmö-, Linköpings-, Uppsala- och Umeå-regionen. Multipel regressionsanalys, därmedelhalterna justerats för kvinnornas ålder, BMI och viktminskning under de senaste tremånaderna, visade att kroppsbelastningen av PCB 153, PCB 156, PCB 180 och HCB var13%-29% högre i Malmö-regionen än i de andra regionerna. Störst skillnad erhölls för -HCH, där kvinnor från Malmö-regionen hade nästan dubbelt så höga medelhalter än kvinnorfrån Uppsala- och Umeå-regionen. I fallet oxyklordan visade de justerade medelvärdena enmotsatt trend, dvs. halterna var högst i norr. Trots att kroppsbelastningen i några fall var högrei vissa regioner var skillnaderna inte dramatiska, vilket antyder att exponeringen för PCB ochklorerade bekämpningsmedel har varit förhållandevis jämn över landet bland den allmännabefolkningen. Resultaten visade att serumhalten av vissa PCB föreningar ökade med ökadkonsumtion av fet fisk bland kvinnorna. De regionala skillnaderna i serumhalt berodde dockinte på skillnader i konsumtion av fet fisk utan beror troligen till viss del på skillnader imiljöbelastning mellan olika regioner.
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| 3. |
- Weiderpass, Elisabete, et al.
(author)
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Estrogen receptor alpha gene polymorphisms and endometrial cancer risk
- 2000
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In: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 21:4, s. 623-627
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Journal article (peer-reviewed)abstract
- Since the estrogen receptor alpha (ER) is an important mediator of hormonal responses such as proliferation in estrogen-sensitive tissues, we hypothesized that polymorphisms in the ER gene could be functional and associated with endometrial cancer risk. We performed a population-based case-control study in Sweden, focusing on restriction fragment length polymorphisms for XbaI and PvuII and an upstream TA repeat polymorphism. In the main analysis, 154 cases and 205 controls who never used hormone replacement therapy took part and we calculated age-adjusted and multivariate odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression. The XbaI X allele appeared to confer a reduced risk for endometrial cancer. The multivariate OR for the XX genotype was 0.52 (95% CI 0.21-1.29) compared to the xx genotype and there were suggestions of decreasing risk with increasing number of X alleles (P for trend = 0.07). The PvuII PP genotype was also associated with a non-significantly decreased risk for endometrial cancer (multivariate OR 0.70, 95% CI 0.34-1.44) compared with the pp genotype (P for trend = 0.43). The multivariate OR for two short TA (<19 repeats) alleles versus two long alleles was 1.54 (95% CI 0. 73-3.27) and there were suggestions of increasing risk with increasing number of short alleles (P for trend = 0.26). We observed the same pattern of results in an expanded group of subjects, which included women who had used hormone replacement (in total 288 cases and 392 controls). Our data suggest that variants of the ER gene may be associated with an altered risk of endometrial cancer.
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