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Träfflista för sökning "(WFRF:(Zhang Wei)) srt2:(2005-2009) srt2:(2005)"

Sökning: (WFRF:(Zhang Wei)) srt2:(2005-2009) > (2005)

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1.
  • Gromada, Jesper, et al. (författare)
  • Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta
  • 2005
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 102:29, s. 10303-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Cytosolic free Ca2+ plays an important role in the molecular mechanisms leading to regulated insulin secretion by the pancreatic beta cell. A number of Ca2+-binding proteins have been implicated in this process. Here, we define the role of the Ca2+-binding protein neuronal Ca2+ sensor-1 (NCS-1) in insulin secretion. In pancreatic beta cells, NCS-1 increases exocytosis by promoting the priming of secretory granules for release and increasing the number of granules residing in the readily releasable pool. The effect of NCS-1 on exocytosis is mediated through an increase in phosphatidylinositol (PI) 4-kinase beta activity and the generation of phosphoinositides, specifically PI 4-phosphate and PI 4,5-bisphosphate. In turn, PI 4,5-bisphosphate controls exocytosis through the Ca2+-dependent activator protein for secretion present in beta cells. Our results provide evidence for an essential role of phosphoinositide synthesis in the regulation of glucose-induced insulin secretion by the pancreatic beta cell. We also demonstrate that NCS-1 and its downstream target, PI 4-kinase beta, are critical players in this process by virtue of their capacity to regulate the release competence of the secretory granules.
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2.
  • Zhang, Wei, et al. (författare)
  • Braided convolutional codes
  • 2005
  • Ingår i: [Host publication title missing]. - 0780391519 ; , s. 592-596
  • Konferensbidrag (refereegranskat)abstract
    • We present a new class of iteratively decodable turbo-like codes, called braided convolutional codes. Constructions and encoding procedures for tightly and sparsely braided codes are introduced. Sparsely braided codes exhibit good convergence behavior with iterative decoding, and a statistical analysis using Markov permutors shows that the free distance of these codes grows linearly with constraint length
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