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An integrated multi...
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
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- Viborg Lindskrog, Sia (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Prip, Frederik (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Lamy, Philippe (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital
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visa fler...
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- Taber, Ann (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Groeneveld, Clarice S. (författare)
- Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France; Inst Curie, UMR144, Oncol Mol, Paris, France,Curie Institute, Paris,Ligue Nationale Contre le Cancer
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- Birkenkamp-Demtröder, Karin (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Bjerggaard Jensen, Jørgen (författare)
- Aarhus Univ, Dept Clin Med, Aarhus, Denmark; Aarhus Univ Hosp, Dept Urol, Aarhus N, Denmark,Aarhus University Hospital
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- Strandgaard, Trine (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Nordentoft, Iver (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital
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- Christensen, Emil (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Sokac, Mateo (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Birkbak, Nicolai J. (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Maretty, Lasse (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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- Hermann, Gregers G. (författare)
- Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen
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- Petersen, Astrid C. (författare)
- Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark,Aalborg University Hospital
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- Weyerer, Veronika (författare)
- Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen
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- Grimm, Marc-Oliver (författare)
- Jena Univ Hosp, Dept Urol, Jena, Germany,Universitätsklinikum Jena
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- Horstmann, Marcus (författare)
- Jena Univ Hosp, Dept Urol, Jena, Germany; St Josephshosp, Dept Urol, Malteser Hosp, Krefeld, Germany,St. Josefs Hospital Uerdingen,Universitätsklinikum Jena
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- Sjödahl, Gottfrid (författare)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Genomiska analyser av urinblåscancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,Urothelial Cancer Genomics,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Urol Res, Malmö, Sweden
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- Höglund, Mattias (författare)
- Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden
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- Steiniche, Torben (författare)
- Aarhus Univ Hosp, Dept Pathol, Aarhus N, Denmark,Aarhus University Hospital
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- Mogensen, Karin (författare)
- Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen
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- de Reyniès, Aurélien (författare)
- Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France,Ligue Nationale Contre le Cancer
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- Nawroth, Roman (författare)
- Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany
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- Jordan, Brian (författare)
- Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine
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- Lin, Xiaoqi (författare)
- Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine
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- Dragicevic, Dejan (författare)
- Univ Belgrade, Fac Med, Clin Ctr Serbia, Clin Urol, Belgrade, Serbia,University of Belgrade,Leeds School of Medicine,Pennsylvania State University,Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA
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- Ward, Douglas G. (författare)
- Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham
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- Goel, Anshita (författare)
- Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham
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- Hurst, Carolyn D. (författare)
- Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England
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- Raman, Jay D. (författare)
- Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA
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- Warrick, Joshua I. (författare)
- Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University
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- Segersten, Ulrika (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi
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- Sikic, Danijel (författare)
- Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Urol & Pediat Urol, Erlangen, Germany,University Hospital Erlangen
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- van Kessel, Kim E. M. (författare)
- Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center
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- Maurer, Tobias (författare)
- Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany; Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany,University Medical Center Hamburg-Eppendorf
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- Meeks, Joshua J. (författare)
- Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine
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- DeGraff, David J. (författare)
- Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University
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- Bryan, Richard T. (författare)
- Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham
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- Knowles, Margaret A. (författare)
- Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Leeds School of Medicine
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- Simic, Tatjana (författare)
- Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia,University of Belgrade
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- Hartmann, Arndt (författare)
- Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen
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- Zwarthoff, Ellen C. (författare)
- Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center
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- Malmström, Per-Uno (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi
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- Malats, Núria (författare)
- CIBERONC, Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain,Spanish National Cancer Research Center (CNIO)
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- Real, Francisco X. (författare)
- Spanish Natl Canc Res Ctr CNIO, Epithelial Carcinogenesis Grp, Madrid, Spain; Univ Pompeu Fabra, Dept Ciencies Expt & Salut, CIBERONC, Barcelona, Spain,Pompeu Fabra University,Spanish National Cancer Research Center (CNIO)
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- Dyrskjøt, Lars (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
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(creator_code:org_t)
- 2021-04-16
- 2021
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations are significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration is associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirms the higher infiltration of class 2b tumors and demonstrates an association between higher immune cell infiltration and lower recurrence rates. Finally, the independent prognostic value of the transcriptomic classes is documented in 1228 validation samples using a single sample classification tool. The classifier provides a framework for biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- Av författaren/redakt...
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Viborg Lindskrog ...
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Prip, Frederik
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Lamy, Philippe
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Taber, Ann
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Groeneveld, Clar ...
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Birkenkamp-Demtr ...
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visa fler...
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Bjerggaard Jense ...
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Strandgaard, Tri ...
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Nordentoft, Iver
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Christensen, Emi ...
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Sokac, Mateo
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Birkbak, Nicolai ...
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Maretty, Lasse
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Hermann, Gregers ...
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Petersen, Astrid ...
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Weyerer, Veronik ...
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Grimm, Marc-Oliv ...
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Horstmann, Marcu ...
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Sjödahl, Gottfri ...
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Höglund, Mattias
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Steiniche, Torbe ...
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Mogensen, Karin
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de Reyniès, Auré ...
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Nawroth, Roman
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Jordan, Brian
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Lin, Xiaoqi
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Dragicevic, Deja ...
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Ward, Douglas G.
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Goel, Anshita
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Hurst, Carolyn D ...
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Raman, Jay D.
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Warrick, Joshua ...
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Segersten, Ulrik ...
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Sikic, Danijel
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van Kessel, Kim ...
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Maurer, Tobias
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Meeks, Joshua J.
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DeGraff, David J ...
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Bryan, Richard T ...
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Knowles, Margare ...
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Simic, Tatjana
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Hartmann, Arndt
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Zwarthoff, Ellen ...
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Malmström, Per-U ...
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Malats, Núria
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Real, Francisco ...
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Dyrskjøt, Lars
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Nature Communica ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet